Pressure perturbations from geologic carbon sequestration: Area-of-review boundaries and borehole leakage driving forces

We investigate the possibility that brine could be displaced upward into potable water through wells. Because of the large volumes of CO2 to be injected, the influence of the zone of elevated pressure on potential conduits such as well boreholes could extend many kilometers from the injection site—farther than the CO2 plume itself. The traditional approach to address potential brine leakage related to fluid injection is to set an area of fixed radius around the injection well/zone and to examine wells and other potentially open pathways located in the “Area-of-Review” (AoR). This suggests that the AoR needs to be defined in terms of the potential for a given pressure perturbation to drive upward fluid flow in any given system rather than on some arbitrary pressure rise. We present an analysis that focuses on the changes in density/salinity of the fluids in the potentially leaking wellbore.Bureau of Economic Geolog

The Beauty Ideal: The Effects of European Standards of Beauty on Black Women

Black women are particularly vulnerable to the effects of European standards of beauty, because these standards emphasize skin colors and hair types that exclude many black women, especially those of darker skin. Using a social work lens, this article explores the black woman’s internalization of European beauty standards through family, peers, the media, and society, and the related outcomes of this internalization on self-perception, academic achievement, sexual behavior, employment, marital status, and mental health. A review of the research indicates that European standards of beauty can have damaging effects on the life trajectories of black women, especially those with dark skin, primarily in the form of internalized self-hatred. Suggestions are made for social work practitioners to address the effects of these internalized European beauty standards among black women through programming and clinical practice

Population Growth Characteristics of Incipient Colonies of the Eastern Subterranean Termite, Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae)

Growth of Reticulitermes flavipes (Kollar) incipient colonies during their first year was documented via a monthly destructive sampling census of 15 unique colonies, each headed by an inbred primary pair, for a total of 180 colonies. King and queen biomass greatly decreased during the first 2 months, coinciding with egg production and colony foundation, but their biomass remained relatively constant thereafter. Three cohorts of eggs were produced, with the greatest number of eggs (mean = 14.5) during the first month. Larvae were present at 1 month, and workers were first observed at 2 months. The survival rate of the initial brood was less than 100%, most likely due to cannibalism. A single soldier was first noted in some colonies at 6 months. Offspring biomass was equal to that of the reproductive pair at the 2-month census, double at 3 months, and quadruple at 11 months. One-year-old colonies ranged in size from 20 to 40 individuals, with an average of 28.9 individuals; total colony biomass was 39.8 mg. The growth rate of these R. flavipes colonies was much slower than was reported in other studies, but our observations are consistent with previous models and suggestions regarding colony growth

A pilot study of the Mistletoe and Breast Cancer (MAB) trial:a protocol for a randomised double-blind controlled trial

BACKGROUND: A Cochrane review of mistletoe therapy concludes that there is some evidence that mistletoe extracts may offer benefits on measures of quality of life during chemotherapy for breast cancer, but these results need replication. Our aim is to add to this evidence base by initially testing the feasibility of a UK pilot placebo-controlled, double-blind randomised controlled trial of mistletoe therapy in patients with breast cancer undergoing chemotherapy with or without radiotherapy. METHODS/DESIGN: A mixed phase pilot placebo-controlled, double-blind randomised controlled trial of mistletoe therapy in patients with breast cancer (EudraCT number: 2018-000279-34). There will be three arms (groups) in the trial: Iscador M, Iscador P, with physiological saline as the placebo. The aim is to recruit 45 adult patients with a new diagnosis of early or locally advanced breast cancer, up to 12 weeks following definitive breast surgery whose standard treatment plan includes chemotherapy with or without radiotherapy. They will be taught to administer the mistletoe and breast cancer (MAB) therapies subcutaneously. MAB therapy will continue throughout their standard chemotherapy and radiotherapy and 1 month beyond. The main outcome of the MAB study is the feasibility of conducting such a trial within the NHS in order to inform a future fully powered investigative trial. Feasibility will be measured through recruitment, retention and patient experience using clinical research forms, patient diaries, cancer-related questionnaires and qualitative interviews conducted with both patients and oncology staff. DISCUSSION: This trial is the first of its kind in the UK. Currently, mistletoe therapy is mostly available through private practice in the UK. Completion of this feasibility study will support applications for further funding for a fully powered randomised controlled trial which will measure effectiveness and cost-effectiveness of this herbal therapy

The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes

Peer reviewedPublisher PD

Perioperative gait analysis after total hip arthroplasty: Does outpatient surgery compromise patient outcomes?

Background: There has been a continuing trend towards decreasing the length of hospital stay for patients undergoing total hip arthroplasty (THA). Outpatient procedures, discharging patients on the same day as surgery, have now become possible yet little research has been done to examine the impact this might have on patients during early recovery. We aimed to investigate the impact of discharge time on gait and patient-reported outcomes in the early post-operative period. Methods: We measured gait velocity, stride length, single-limb support and single-limb support symmetry preoperatively, at discharge from the hospital, and two-, six- and 12-weeks postoperatively. Participants also completed the Timed Up and Go and a series of questionnaires (WOMAC, SF-12, Harris Hip Score and pain VAS) at each visit. Results: Thirty-six participants undergoing a direct anterior THA with a single surgeon were enrolled in this study. Sixteen participants were discharged on the same day as surgery (outpatient group), while 20 stayed at least one night in hospital (inpatient group). We found pain at time of discharge to be significantly lower in the outpatient group compared to the inpatient group (p=0.04). We found no other differences between the groups for any gait, patient-reported or surgical outcomes (p\u3c0.05). Conclusion: Following a direct anterior total hip arthroplasty, patients who stayed overnight had significantly more pain at discharge than those discharged as outpatients. There were no differences in gait or patient-reported outcomes between groups. Interdisciplinary Reflection: This study incorporates aspects of kinesiology, surgery, rehabilitation and health policy

Immunization with the C-domain of α-toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens

© 2004 by the Infectious Diseases Society of America. All rights reserved.Clostridium perfringens gas gangrene is characterized by rapid tissue destruction, impaired host response, and, often, death. Phospholipase C (α-toxin) is the virulence factor most responsible for these pathologies. The present study investigated the efficacy of active immunization with the C-terminal domain of α-toxin (Cpa247–370) in a murine model of gas gangrene. Primary end points of the study were survival, progression of infection, and tissue perfusion. Secondary end points, which were based on findings of histologic evaluation of tissues, included the extent of tissue destruction and microvascular thrombosis, as well as the magnitude of the tissue inflammatory response. Survival among C-domain–immunized animals was significantly greater than that among sham-immunized control animals. Furthermore, immunization with the C-domain localized the infection and prevented ischemia of the feet. Histopathologic findings demonstrated limited muscle necrosis, reduced microvascular thrombosis, and enhanced granulocytic influx in C-domain–immunized mice. We conclude that immunization with the C-domain of phospholipase C is a viable strategy for the prevention of morbidity and mortality associated with C. perfringens gas gangrene

Intake of Supplemental Deer Pellets Containing Ground Blueberry Juniper by Wild Pigs

Supplemental feeding of cervid species such as white-tailed deer (Odocoileus virginianus; deer) is now a common management practice in the United States. Supplemental feeding can be costly and more expensive when supplements are consumed by non-target species such as wild pigs (Sus scrofa; pigs). From May 13 to June 17, 2015, we evaluated the effects of using ground blueberry juniper (Juniperus ashei) or cottonseed (Gossypium spp.) hulls as a roughage ingredient in a supplemental deer pellet to deter pig consumption at the Texas A&M AgriLife Research Center in San Angelo, Texas, USA. We analyzed dry matter intake, growth performance, in vitro digestibility and fermentation, and blood serum chemistry of pigs using a 2 × 2 factorial study design that included 3 feeding periods. Pigs were assigned to 1 of 4 supplement diets (n = 5 pigs/supplement) or to a commercially available swine diet (BASAL; n = 4 pigs). Animals assigned to supplement diets were also offered BASAL based on percentage of body weight (BW) during each period. Supplement diets differed by roughage source and percentage of roughage: cottonseed hulls 20%, cottonseed hulls 40%, blueberry juniper 20%, or blueberry juniper 40%. During each period, the amount of supplement and BASAL diet offered to animals assigned to a supplement was fed as a percentage of BW; period 1 (day 0 to 17) = 5% supplement diet and 5% BASAL diet, period 2 (day 18 to 26) = 5% supplement diet and 2% BASAL diet, period 3 (day 27 to 34) = 5% supplement diet and 5% BASAL diet. Animals assigned to only BASAL were offered the same amount of feed as a percent of BW as supplement animals during each period. We observed a roughage × period interaction (P = 0.03) for supplement dry matter intake g/day and a roughage × period interaction (P \u3c 0.09) for total dry matter intake as a percentage of BW. No differences were observed within period. No other variables had percent roughage x period differences. Ground blueberry juniper was indigestible by pigs; the in vitro digestibility of dry matter and gross energy was \u3c 1%. Greater blood serum alanine aminotransferase (P= 0.07) in pigs consuming experimental supplement diets suggested the possibility of liver damage. Our findings suggest that there does not appear to be a benefit of using ground juniper as a roughage source to reduce consumption of supplemental deer feed by pigs