Physiological studies on the effects of hormonal imbalance on the central nervous system

The acetylcholinesterase activity, RNA levels, total free amino acids and magnesium content in fore-, mid- and hind-brain were determined in the normal and hypophysectomised frogs (Rana cyanophlyctus). Hypophysectomy results in a marked decrease in the freea−a and in Mg. RNA also decreases significantly, but not to the same degree as thea−a and Mg. But AchE levels do not change significantly although there is a general decrease. It is suggested that the decrease in Mg is a reflection of the ionic imbalance resulting from hormonal imbalance. Hypophysectomy also results in reduced protein synthesis (and/or turnover) in the CNS as indicated by reduced RNA anda−a

A drug utilization study of antiepileptic drugs uses in a tertiary care teaching hospital of India

Background: Epilepsy is a disorder characterized by repeated seizures due to the disorder of the neurons. Epilepsy needs life-long medical therapy. It is managed by polytherapy. Drug utilization studies help to determine rational combinations of drug use in epilepsy. Aims and objectives of the study were to analyses the drug utilization pattern of anti-epileptics and common types of epileptic seizures and to determine the safety of antiepileptic drugs (AEDs).Methods: It was a prospective, cross-sectional, observational study. Patients attending neurology epilepsy OPD with h/o seizures and taking at least one antiepileptic were recruited. Data was collected by taking demographic details including brief history of disease, clinical examination and reviewing OPD prescription. Details were recorded in case record form.Results: We recruited 102 participants (57 male and 45 females) of mean age 29.68±10.52. Mean age of onset of epilepsy was 18.9±10.5 years. Among them 77 (75.4%) were diagnosed as generalized tonic clonic seizures and 18 (17.6%) were diagnosed as focal seizures. Monotherapy was given in 31 (30.3%) patients while polytherapy was given in 71 (69.7%) patients. Valproic acid was most commonly used monotherapy (12 patients). No fixed drug combinations were used. Clobazam in 55 (53.9%) patients and valproic acid in 53 (51.9%) patients were prescribed. The other AEDs prescribed were lamotrigine, oxcarbazepine, carbamazepine, lacosamide, zincosamide, perampanel, and phenytoin. All antiepileptics were prescribed in brand name. The prescribed daily dose (PDD) was less than defined daily dose (DDD) as per anatomical therapeutic chemical (ATC) classification. Two adverse effects were reported during study period. They were mood change and blurring of vision in two different patients.Conclusions: The PDD was less than DDD as per ATC classification. Awareness should be created among neurologists to prescribe more generic drugs because of their cost effectiveness. Studies are needed with larger sample size to analyze the drug utilization patterns which helps in the planning of reduction of expenditure for the patient without compromising efficacy

Physiological studies on the effects of hormonal imbalance on the central nervous system. I. Effects of hypophysectomy on certain biochemical parameters in the brain of frog

Hypophysectomy resulted in a marked decrease in the free amino acid and Mg contents of fore-​, mid-​, and hindbrain segments. RNA levels and acetylcholinesterase activity decreased to a lesser extent

Rakshak - A Rescue Bot

Robotics is the field of designing and innovation that assumes a vital part in making our lives simpler to perform different undertakings. The primary point of the venture is to outline and build up, a sensor based mechanical arm which is controlled by human hand. The venture manages controlling a servo mechanical arm with the assistance of movement detecting innovation by Flex sensor and 3-hub accelerometer. The pick and place operation of the mechanical arm can be controlled utilizing Arduino. This framework can be utilized as a part of enterprises, dangerous conditions, biomedical surgeries and different applications

रसवादाः - रसस्वरूपनिरूपणम्

रससम्प्रदायस्य प्रप्रथमप्रवर्तकः भरतः इति सर्वेषामालङ्कारिकाणामभिप्रायः। भरतस्य “नाट्यशास्त्रम्” इति ग्रन्थः सुप्रसिद्धः, सर्वेषामालङ्कारिकाणाम् अलङ्कारशास्त्रविषये आधारभूतः ग्रन्थः इति च सर्वेषां विदुषाम् अभिप्रायः। रसस्वरूपनिरूपणविषये भरतमुनिः येषां सिद्धान्तानां प्रतिपापादनं कृतवान्, प्रायशः तेषामेव सिद्धान्तानां प्रतिपादनं एवं व्याख्यानञ्च तदितरैः आचार्यैः कृतम्। भरतमुनिना प्रतिपादितं यत् – “न हि रसादृते कश्चिदर्थः प्रवर्तते” । इति। एवं भरतः नाट्यशास्त्रे रससूत्रमेवं प्रस्तुतवान् – “विभावानुभावव्यभिचारिसंयोगाद्रसनिष्पत्तिः” इति। वस्तुतः भरतकृतनाट्यशास्त्रस्य रससूत्रमतिसरलं सुस्पष्टञ्च वर्तते। परन्तु इदं रससूत्रं व्याख्याकाराणां अनेकव्याख्यभिः अतिक्लिष्टं सञ्जातम्। रससूत्रस्य विभावानुभावव्यभिचारिपदानां व्याख्याने न काऽपि विमतिः। परं संयोगनिष्पत्तिपदयोः व्याख्याने एव विद्वद्भिः मतान्तराणि प्रस्थापितानि। तानि मतानि काव्यप्रकाशगतरसस्वरूपनिरूपणमिति मम पत्रे प्रस्तोतुमिच्छामि

Antisteroidogenic activity of floral extract of <i>Thespesia populnea </i>Corr. in <span style="font-size:14.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";color:black;mso-ansi-language:EN-IN; mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">mouse ovary</span>

1241-1242Anti-steroidogenic activity of various extracts of T.populnea was screened in female albino mice. The weight of the uterus and ovaries were reduced significantly and the cholesterol and ascorbic acid content in ovaries were significantly elevated due to the treatment with extract of T. populnea. The significant inhibition of Δ5 , 3β hydroxy steroid dehydrogenase and glucose-6-phosphate dehydrogenase, the two key enzymes involved in ovarian steroidogenesis were also observed in mouse ovaries after 15 days of treatment

Acute posterior circulation infarct due to bicuspid aortic valve vegetation: An uncommon stroke mechanism

Acute ischemic stroke may be the first clinical manifestation of the underlying cardioembolic source. We are reporting a 28-year-old man presenting with acute posterior circulation infarct due to underlying bicuspid aortic valve disease with vegetation detected by transesophageal echocardiography in the absence of clinical features of heart disease and infective endocarditis. The case report highlights the importance of routine evaluation of cardioembolic sources in all cases of ischemic stroke

Factors associated with poor outcome in tuberculous meningitis; study from a tertiary care referral Centre from South India

Introduction: Tuberculosis (TB) remains a worldwide burden with a large majority of new active cases occurring in underdeveloped and developing countries. This study is an attempt to look into various aspects of the disease that can be associated with the outcome, to promote a timely referral to an appropriate centre. Purpose: To identify various clinical, lab, CSF and radiological variables associated with poor outcome of TBM at the time of discharge. Material &amp; Methods: Demographic data, duration of symptoms before diagnosis, clinical presentation, staging of the disease at the time of admission of all the TBM patients who presented to our centre between December, 2015 and May 2018 were noted. Results of biochemical investigations and brain and spine imaging were retrieved. Outcome at the time of discharge as measured by MRC and mRS grades was correlated to clinical profile, lab, CSF and radiological findings. Results: A total of 100 patients were included. 15 patients died. Subjects with MRC and mRS grades of 2 or more at admission constituted 65% and 93% respectively. At discharge, MRC and mRS grades of 2 or more were found in 29.63% and 39% respectively. Multivariable analysis showed a significant positive association of MRC stage at discharge with MRC stage (p = 0.001) and mRS score (p = 0.001) at admission and Vellore hydrocephalus grade (p &lt; 0.001) when hydrocephalus first identified. Similarly, mRS score at discharge had an independent positive association with the MRC stage (p &lt; 0.001) and the mRS score (p=0.002) at admission. Conclusion: Stage of the disease (MRC) and functional status of the patient (mRS) at admission are the two most important independent factors determining the outcome of TBM patients at the time of discharge

Using PPI-GA for identifying protein complexes in protein-protein interaction networks

The major focus of an interdisciplinary field of study termed proteomics is a comprehensive analysis of proteins to evaluate their genetic variety, examine their distinctions, and respond to stresses. Proteomics' major goal is to use protein chemistry, bioinformatics, and biology to detect and measure proteins as well as analyze their post-translational modifications and interactions. Any disruption in the interacting network of proteins can lead to biological abnormalities and diseases like Alzheimer's and cancer. The majority of existing computational approaches for detecting protein complexes are based on certain topological properties of protein-protein networks (PPI). In this paper, it initially provides a novel encoding technique for representing the clarification and solution, and next we recommend the concept of PPI-GA, an innovative clustering based algorithm which is based on genetic approach algorithm which employs a innovative multi based objective excellence function to find out the protein complexes. A different two gold based standard and the real-world based datasets are been used to evaluate proposed algorithm. The obtained result shows that the suggested method can discover key protein complexes and that it offers more accurate results than existing protein complex identification techniques