Multi-dimensional parametric assessment with IoT in acquaintance of digital pipeline

In IoT researches are found millions of devices are connected in global digital infrastructure framed in network fashion. Most of the things on the network use cloud or central database to share their data and control signals to control and manage the devices on the IoT network. Devices on the network need fast traversing paths, to take correct decision in right time. The data synchronization between source and destination is very important in real time parameter maintenance. The multidimensional parametric evaluation of the environment or the surrounding area is facing problems with data synchronization and congestion in the sensor network. This will lead arrival of fault data at the destination. The fault data also leads a misconception at user end. In the present work pipeline integration is proposed to overcome the misconception and synchronization failures. The pipeline and Arduino UNO processor are integrated on Proteus simulation tool. Transducer nodes and the functionalities are analysed with pipeline

METHOD DEVELOPMENT AND VALIDATION STUDY FOR QUANTITATIVE DETERMINATION OF GENOTOXIC IMPURITY AND ITS PRECURSOR IN FLUCONAZOLE SAMPLE BY LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY

Objective: The objective of this work is method development and validation study for quantitative determination of 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole, a genotoxic impurity and its precursor in a fluconazole drug sample by liquid chromatography–tandem mass spectrometry.Methods: LC-MS/MS analysis of these impurities was performed on Hypersil BDS C18 (100 mm x 4.0 mm, 3 µm) column. 5 mmol ammonium acetate and acetonitrile in the ratio of 65:35 (v/v) was used as the mobile phase with a flow rate of 0.4 ml/min. The developed method was accomplished with a short run time of 10 min. Triple quadrupole mass detector coupled with positive electrospray ionization was used for the quantification of genotoxic impurities in multiple reaction monitoring (MRM).Results: The method was validated as per International Conference on Harmonization (ICH) guidelines. The method was linear in the range of 0.30 µg/g to 11.37 µg/g for impurity A and 0.30 µg/g to 11.34 µg/g for impurity B with a correlation coefficient of 0.999. The accuracy of the method was in the range of 98.25 % to 100.53 % for both impurities.Conclusion: A specific, selective, highly sensitive and more accurate analytical method using LC-MS/MS coupled with positive electrospray ionization has been developed for the quantification of genotoxic impurity (1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole) and its precursor (1-(2,4-difluorophenyl)-2-[1,2,4]triazol-1-yl-ethanone) at 0.3 µg/g with respect to the 5.0 mg/ml of fluconazole

Level of physical activity, determinants and barriers to motivate physical activities among south Indian diabetic patients: a prospective, questionnaire based study

Background: Several clinical trials have been reported that sedentary lifestyle modification including physical activity (PA) and weight loss significantly alters the sort-term as well as long-term incidence of diabetes. The present study explored the level of physical activity and its barriers among south Indian naïve patients who are attending the tertiary care teaching hospital.Methods: A prospective observational, questionnaire-based study. Patients with diabetes (both Type-1 and 2) who were attended diabetic clinic in the Department of General Medicine, Maharaja Institute of Medical Sciences (MIMS), Vijayanagaram, Andhra Pradesh, India was selected and recruited. Demographic data, clinical data were collected from the study participants. International Physical Activity questionnaire was used to determine each patient level of physical activity (PA). Physical activity is graded into low (3000 MET).Results: A total of 300 subjects were completed the entire study. Majority (62.7%) of the patients were suffering from Type-2 diabetes mellitus. Both male and female study subjects had low physical activity (70.5% and 74.1%) and moderate PA was seen in only one thirds of the patients. Patients with low physical activity had low glycaemic control compared to patients who were involved in moderate PA. Moderate PA patients had adequate glycaemic control (65.9 vs 34.1%, P <0.001). A total of 42.0% of subjects were suffering from one of the joint pains and friction joints, due to the following reason subjects were not involved in the PA.Conclusions: Low level of physical activity was observed in the study population, which is a risk factor for several micro-vascular complications over a period of time. It is very important to address the barriers of PA and vigorous counselling is needed which directs towards increasing PA

Promoting the adoption of improved ICM technologies in chickpea by poor farmers in Nepal

Chickpea is an important source of protein in Nepal for both poor rural and urban families. Yields of legumes including chickpea have decreased in recent years, primarily due to disease and insect pest problems, and the reluctance of farmers to invest time and money in a crop which increasingly fails. This project aimed to improve, validate and evaluate a complete integrated crop management (ICM) strategy for chickpea on farms; to persuade farmers to adopt the strategy through workshops and farm trials in some of the poorest areas of Nepal; and to promote the strategy widely to the press. and other stakeholders. The improved seed and technologies offered were in high demand by farmers, and the project produced evidence to show that the outputs (increased yield of a cash crop) have been translated into significant impacts on livelihood, including improved housing, debt repayment, education costs, clothes and healthcare. The value of the improved seed has been impressive and will benefit farmers in the longer term. An innovative promotional strategy promoted the findings to policymakers as well as farmers, and used the popular media in Nepal and the UK to publicise the wor

Ceramic Materials (Phosphors) for Display Applications

Phosphors the ceramic materials should able to work in tough environment surrounded and bombarded by high energy Vacuum Ultra Violet (VUV), UV or electron beam radiations in any discharge tube. The plasma display panel (PDP) is increasingly gaining attention over conventional cathode ray tube (CRT)-based TVs as a medium of large format (60+”) television (TV), particularly high definition TVs (HDTVs). Improvements have been made not only in size but also in other areas such as resolution, luminescence efficiency, brightness, contrast ratio, power consumption, and cost reduction. The formation of a phosphor host and doping process by solid solution is critical and is highly dependent on the reaction temperature and conditions. Since the purity of starting chemicals is very important to the synthesis of phosphors, the starting chemicals are typically 99.9%, 99.999% in purity. Required amounts of starting ingredients are mixed in the presence of an appropriate flux (if necessary) and fired at high temperatures (1200 °C) in air or in a controlled atmosphere (N2, C, CO, or N2 with 2-5% of H2). The present paper reports the synthesis and luminescence characteristics of different ceramic materials (phosphors) for display applications

Specimen Level and Component Level Simulations of Fatigue Crack Growth Behavior under Cyclic Bending

Power plant piping system subjected to many cyclic loading conditions leads to fatigue loading and thereby crack initiation in the piping system. Demonstrating Leak-Before-Break (LBB) in the design stage itself plays an important role in ensuring the safety of the Sodium-cooled Fast Reactors (SFR) system. The design code guidelines as per RCC MRx A16 in LBB demonstration is conservative in nature. Conducting experiments for each size of the piping systems are expensive and time-consuming. In this paper present, the efforts taken to develop reliable numerical methods to demonstrate Fatigue Crack Growth (FCG). The geometries selected for the FCG analysis include both specimen level as well as full-scale component. The results show that KI estimate for the plate specimen increased with the increase of ‘a/t’ ratio up to 0.6 and then decreases, whereas, in case of the pipe bend, it reduced beyond the ‘a/t’ ratio of 0.4. This early reduction is due to the influence of global compressive stress present ahead of the crack growth. Thus, component level FCG simulation is essential for the accurate demonstration of LBB. FCG simulation has numerically demonstrated with better engineering accuracy for both specimen level as well as component level geometrie

Synthesis and Characterization of Sr2CeO4 Phosphor Doped with Erbium

The present paper reports the Photoluminescence (PL) of the Sr2CeO4 phosphor, singly doped with Erbium rare-earth ion with different concentrations (0.01, 0.1, 0.2, 0.5 and 1%).The phosphor samples were synthesized using the standard solid state reaction technique. The effect of Er dopant on the structural, morphological, and Photoluminescent properties of the samples are studied with X-ray diffraction (XRD), PL and SEM analysis. The PL emission of undoped Sr2CeO4 phosphor was observed at 470 nm with high intensity followed by the primary Er emissions with good intensity at 525, 530, 549, 557 and 565 nm

First report on induced spawning of Siganus vermiculatus in India

Siganids are widely distributed to Indo-West Pacific region and the Siganus vermiculatus (Maze rabbit fish/Vermiculated spinefoot) can reach sizes that weigh up 2.3 kg each. It is a species of great aquaculture importance and hence breeding and seed production protocols are necessary. A major breakthrough in the seed production of Siganus vermiculatus by inducing the fishes to spawn under controlled conditions with Human Chorionic Gonadotropin (hCG) during the first quarter of the lunar cycle is reported. The hatchery processes and early larval stages are described

Myelomatosis with type III hyperlipoproteinemia - clinical and metabolic studies

We investigated the metabolism of intermediate-density lipoproteins (IDL [1.006 to 1.019 g per milliliter]) and low-density lipoproteins (LDL [1.019 to 1.063 g per milliliter]) in two men with Type III hyperlipoproteinemia associated with myelomatosis. In vivo kinetic studies using Radio-labeled autologous lipoproteins demonstrated a greatly reduced fractional catabolic rate of IDL, relative to control values (patients vs. normal, 0.006 and 0.025 per hour vs. 0.20±0.08 per hour [mean ±S.E.M.]) and a greatly prolonged IDL-to-LDL conversion time (45 and 17 hours vs. 5.4±1.6 hours). In studies in vitro, LDL from both patients failed to bind to the LDL receptor of normal blood lymphocytes, whereas LDL from subjects with familial Type III hyperlipoproteinemia bound normally to the receptor. In one patient immunoglobulin was shown to be associated with IDL and LDL. Thus, hyperlipoproteinemia reflected an impaired metabolism of IDL, probably secondary to the binding of immunoglobulin to the lipoproteins. A similar impairment of receptor-mediated LDL catabolism did not elevate the plasma LDL concentration because of the low IDL-to-LDL conversion rate