13 research outputs found
New Measure of Insulin Sensitivity Predicts Cardiovascular Disease Better than HOMA Estimated Insulin Resistance
10.1371/journal.pone.0074410PLoS ONE89-POLN
Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: The Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study
10.1093/ajcn/nqaa055AMERICAN JOURNAL OF CLINICAL NUTRITION112139-47AJCNAGUSTO (Growing up towards Healthy Outcomes)GUSTO (Growing up towards Healthy Outcomes
Trajectories of Systolic Blood Pressure in Children: Risk Factors and Cardiometabolic Correlates
10.1016/j.jpeds.2021.05.027The Journal of Pediatric
Faster eating rates are associated with higher energy intakes during an ad libitum meal, higher BMI and greater adiposity among 4·5-year-old children: results from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort
Faster eating rates are associated with increased energy intake, but little is known about the relationship between children's eating rate, food intake and adiposity. We examined whether children who eat faster consume more energy and whether this is associated with higher weight status and adiposity. We hypothesised that eating rate mediates the relationship between child weight and ad libitum energy intake. Children (n 386) from the Growing Up in Singapore Towards Healthy Outcomes cohort participated in a video-recorded ad libitum lunch at 4·5 years to measure acute energy intake. Videos were coded for three eating-behaviours (bites, chews and swallows) to derive a measure of eating rate (g/min). BMI and anthropometric indices of adiposity were measured. A subset of children underwent MRI scanning (n 153) to measure abdominal subcutaneous and visceral adiposity. Children above/below the median eating rate were categorised as slower and faster eaters, and compared across body composition measures. There was a strong positive relationship between eating rate and energy intake (r 0·61, P<0·001) and a positive linear relationship between eating rate and children's BMI status. Faster eaters consumed 75 % more energy content than slower eating children (Δ548 kJ (Δ131 kcal); 95 % CI 107·6, 154·4, P<0·001), and had higher whole-body (P<0·05) and subcutaneous abdominal adiposity (Δ118·3 cc; 95 % CI 24·0, 212·7, P=0·014). Mediation analysis showed that eating rate mediates the link between child weight and energy intake during a meal (b 13·59; 95 % CI 7·48, 21·83). Children who ate faster had higher energy intake, and this was associated with increased BMI z-score and adiposity
Prediction of cardio-metabolic events at follow up using ISI-cal and HOMA-IR in the independent cohort.
<p>CVD – cardiovascular disease, HOMA-IR – homeostatic model of insulin resistance, ISI-cal – calculated insulin sensitivity.</p><p>a – N– total number of subjects with follow up; b – number of positive events at follow up.</p
Comparison of ISI-cal with HOMA-IR in validation group from the SAMS study.
<p>N = 208; P = 0.024 HOMA-IR – homeostatic model of insulin resistance, ISI-cal – calculated insulin sensitivity, SAMS – Singapore Adult Metabolism study.</p
Baseline characteristics of subjects in SAMS and an independent cohort.
<p>BMI – body mass index, FPG – fasting plasma glucose, WHR – waist hip ratio.</p
Metabolic effects of brown fat in transitioning from hyperthyroidism to euthyroidism
10.1530/eje-21-0366European Journal of Endocrinology1854553-56