278 research outputs found
Bipolar polaron pair recombination in P3HT/PCBM solar cells
The unique properties of organic semiconductors make them versatile base
materials for many applications ranging from light emitting diodes to
transistors. The low spin-orbit coupling typical for carbon-based materials and
the resulting long spin lifetimes give rise to a large influence of the
electron spin on charge transport which can be exploited in spintronic devices
or to improve solar cell efficiencies. Magnetic resonance techniques are
particularly helpful to elucidate the microscopic structure of paramagnetic
states in semiconductors as well as the transport processes they are involved
in. However, in organic devices the nature of the dominant spin-dependent
processes is still subject to considerable debate. Using multi-frequency pulsed
electrically detected magnetic resonance (pEDMR), we show that the
spin-dependent response of P3HT/PCBM solar cells at low temperatures is
governed by bipolar polaron pair recombination involving the positive and
negative polarons in P3HT and PCBM, respectively, thus excluding a unipolar
bipolaron formation as the main contribution to the spin-dependent charge
transfer in this temperature regime. Moreover the polaron-polaron coupling
strength and the recombination times of polaron pairs with parallel and
antiparallel spins are determined. Our results demonstrate that the pEDMR pulse
sequences recently developed for inorganic semiconductor devices can very
successfully be transferred to the study of spin and charge transport in
organic semiconductors, in particular when the different polarons can be
distinguished spectrally
Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Afford New Opportunities in Inherited Cardiovascular Disease Modeling
Fundamental studies of molecular and cellular mechanisms of cardiovascular disease pathogenesis are required to create more effective and safer methods of their therapy. The studies can be carried out only when model systems that fully recapitulate pathological phenotype seen in patients are used. Application of laboratory animals for cardiovascular disease modeling is limited because of physiological differences with humans. Since discovery of induced pluripotency generating induced pluripotent stem cells has become a breakthrough technology in human disease modeling. In this review, we discuss a progress that has been made in modeling inherited arrhythmias and cardiomyopathies, studying molecular mechanisms of the diseases, and searching for and testing drug compounds using patient-specific induced pluripotent stem cell-derived cardiomyocytes
Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis
<p>Abstract</p> <p>Background</p> <p>Oct4 is a POU-domain transcriptional factor which is essential for maintaining pluripotency in several mammalian species. The mouse, human, and bovine <it>Oct4 </it>orthologs display a high conservation of nucleotide sequence and genomic organization.</p> <p>Results</p> <p>Here we report an isolation of a common vole (<it>Microtus rossiaemeridionalis) Oct4 </it>ortholog. Organization and exon-intron structure of vole <it>Oct4 </it>gene are similar to the gene organization in other mammalian species. It consists of five exons and a regulatory region including the minimal promoter, proximal and distal enhancers. Promoter and regulatory regions of the vole <it>Oct4 </it>gene also display a high similarity to the corresponding regions of <it>Oct4 </it>in other mammalian species, and are active during the transient transfection within luciferase reporter constructs into mouse P19 embryonic carcinoma cells and TG-2a embryonic stem cells. The vole <it>Oct4 </it>gene expression is detectable starting from the morula stage and until day 17 of embryonic development.</p> <p>Conclusion</p> <p>Genomic organization of this gene and its intron-exon structure in vole are identical to those in all previously studied species: it comprises five exons and the regulatory region containing several conserved elements. The activity of the <it>Oct4 </it>gene in vole, as well as in mouse, is confined only to pluripotent cells.</p
Isolation and screening of microorganisms from a gari fermentation process for starter culture development
Cassava (Manihot esculenta Crantz), is used for the production of a variety of West African foods and ranks fourth in the list of major crops in developing countries after rice, wheat and maize. Gari is one of the most popular foods produced from cassava. Cassava may contain high levels of linamarin, a cyanogenic glucoside, which in its natural state is toxic to man. Therefore, some processing methods that can enhance the detoxification of cassava and lead to the improvement of the quality and hygienic safety of the food are vitally important for less toxic products to be obtained. Quality, safety and acceptability of traditional fermented foods may be improved through the use of starter cultures. There has been a trend recently to isolate wild-type strains from traditional products for use as starter cultures in food fermentation. A total of 74 bacterial strains and 21 yeast strains were isolated from a cassava mash fermentation process in a rural village in Benin, West Africa. These strains were assessed, together with 26 strains isolated at the Council for Scientific and Industrial Research (CSIR) from cassava samples sent from Benin previously, for phenotypic and technological properties. 24 presumptive lactic acid bacteria (LAB) were selected for further phenotypic, genotypic and technological characterization.Key words: Lactic acid bacteria, gari, cassava, fermentation
Interpreting Attoclock Measurements of Tunnelling Times
Resolving in time the dynamics of light absorption by atoms and molecules,
and the electronic rearrangement this induces, is among the most challenging
goals of attosecond spectroscopy. The attoclock is an elegant approach to this
problem, which encodes ionization times in the strong-field regime. However,
the accurate reconstruction of these times from experimental data presents a
formidable theoretical challenge. Here, we solve this problem by combining
analytical theory with ab-initio numerical simulations. We apply our theory to
numerical attoclock experiments on the hydrogen atom to extract ionization time
delays and analyse their nature. Strong field ionization is often viewed as
optical tunnelling through the barrier created by the field and the core
potential. We show that, in the hydrogen atom, optical tunnelling is
instantaneous. By calibrating the attoclock using the hydrogen atom, our method
opens the way to identify possible delays associated with multielectron
dynamics during strong-field ionization.Comment: 33 pages, 10 figures, 3 appendixe
Sub-Poissonian statistics in order-to-chaos transition
We study the phenomena at the overlap of quantum chaos and nonclassical
statistics for the time-dependent model of nonlinear oscillator. It is shown in
the framework of Mandel Q-parameter and Wigner function that the statistics of
oscillatory excitation number is drastically changed in order-to chaos
transition. The essential improvement of sub-Poissonian statistics in
comparison with an analogous one for the standard model of driven anharmonic
oscillator is observed for the regular operational regime. It is shown that in
the chaotic regime the system exhibits the range of sub- and super-Poissonian
statistics which alternate one to other depending on time intervals. Unusual
dependence of the variance of oscillatory number on the external noise level
for the chaotic dynamics is observed.Comment: 9 pages, RevTeX, 14 figure
The response of perennial and temporary headwater stream invertebrate communities to hydrological extremes
The headwaters of karst rivers experience considerable hydrological variability, including spates and streambed drying. Extreme summer flooding on the River Lathkill (Derbyshire, UK) provided the opportunity to examine the invertebrate community response to unseasonal spate flows, flow recession and, at temporary sites, streambed drying. Invertebrates were sampled at sites with differing flow permanence regimes during and after the spates. Following streambed drying at temporary sites, dewatered surface sediments were investigated as a refugium for aquatic invertebrates. Experimental rehydration of these dewatered sediments was conducted to promote development of desiccation-tolerant life stages. At perennial sites, spate flows reduced invertebrate abundance and diversity, whilst at temporary sites, flow reactivation facilitated rapid colonisation of the surface channel by a limited number of invertebrate taxa. Following streambed drying, 38 taxa were recorded from the dewatered and rehydrated sediments, with Oligochaeta being the most abundant taxon and Chironomidae (Diptera) the most diverse. Experimental rehydration of dewatered sediments revealed the presence of additional taxa, including Stenophylax sp. (Trichoptera: Limnephilidae) and Nemoura sp. (Plecoptera: Nemouridae). The influence of flow permanence on invertebrate community composition was apparent despite the aseasonal high-magnitude flood events
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