Determination of rate and analysis of reasons for discarding blood and blood components in a blood bank of tertiary care hospital:a retrospective study

Background: The transfusion of blood and blood components has become an integral part of patient management in modern medicine. There are no substitutes for human blood. Thus, proper utilization of blood is necessary with minimal wasting.Methods: A total of 15,333 donors donated blood during the study period of 3 years in blood bank of a tertiary care hospital, south Maharashtra from 1 st of January, 2013 to 31 st December 2015, which were screened.Results: Of the total 3355 whole blood collection, 615 blood bags were discarded. Out of these 615 bags 544 (88.45%) were discarded because of date expired, 41(6.66%) blood bags were discarded due to seropositivity for TTI and 22 (3.5%) blood bags were due under collection and leakage and other reasons contributed for 1.3%. A total of 4026 blood components were discarded against 29,715 blood components prepared during the study period. Among blood components discarded, most common units were platelets. The most common cause of discarding the blood components was expiry of date due to non-utilization were 3475 (86.31%).Conclusions: Properly implemented blood transfusion policies, training of staff as well as implementation of automation will also help to improve process and output of BTS. This would reduce the discarding of blood components and wastage due to non-conformance. These discarded bags, because they are unutilized are both financially as well as socially harmful to the blood bank

Adverse blood transfusion reactions at tertiary care hospital

Background: The goal of hemovigilance is to increase the safety and quality of blood transfusion. It is necessary to recognize and prompt response to adverse transfusion reactions, which will help in taking appropriate steps to reduce their incidence and make blood transfusion process as safe as possible. The aim of the study was to determine the frequency and type of transfusion reactions (TRs) occurring in patients, reported to the blood bank at our institute.Methods: A retrospective review of all TRs reported to the blood bank Krishna Hospital, between January 2011 and July 2013 was done. All the TRs were evaluated in the blood bank and classified using standard definitions.Results: During the study period a total 13126 units of blood and components were issued by our blood bank and total of 45 (0.3%) adverse reactions were reported to blood bank. The most common reaction observed was allergic reaction 25(55.6%) followed by FNHTR 15 (33.3%).Conclusions: Not a single case of anaphylactic reactions, TRALI, acute immune hemolytic transfusion reaction, and Sepsis was observed. This can be an underestimation of the true incidence because of under reporting which can be improved by proper hemovigilence system to provide better patient care.

ANAESTHESIA CHALLENGES DURING MANAGEMENT OF EMERGENCY CESAREAN SECTION IN A POST-PNEUMONECTOMY PRIMIGRAVIDA WITH PLACENTA PREVIA

Pulmonary disease is a known risk factor for perioperative respiratory complications. So anesthesiologists are expected to experience these postpneumonectomy patients coming for elective or emergency surgeries. But there is little data to anesthesia management for cesarean delivery of postpneumonectomy parturient. On reviewing the literature, there is only one reported case of the trial of vaginal delivery followed by cesarean section done under epidural anesthesia, a 41 years-old parturient having preoperative respiratory failure and pneumonia in the antenatal period which was managed on continuous positive airway pressure (CPAP) simultaneously. Our case presented a 24 years-old primigravida of 34 weeks gestation with placenta previa and complaints of two days per vaginal bleeding was posted for the emergency cesarean section. She had past history of left lung lobectomy 10 years back, video bronchoscopy 3 years back and history of admission for treatment of an episode of pneumonia at 32 weeks of present gestation. Emergency cesarean section was managed successfully under spinal anesthesia. This case report highlights that spinal anesthesia may remain a good option in anesthesia management for cesarean section in a primigravida with postpneumonectomy

Honey as a potent natural supplement for diverse human ailments

Abstract The use of natural honey (NH) as a medicinal agent is associated with a vast range of health benefits and therapeutic promises. The tradition of using honey as a potent food supplementation and medicinal component exist in several countries cutting across traditions and civilizations. This review revisits the wide spectrum of medicinal properties that are associated with honey in the light of modern research and attempts to impart the much needed data required to provide this natural food the status of evidence based medicine. Subjects as diverse as diabetes, cardiology and ophthalmology were covered where beneficial medical properties of honey has been demonstrated and the review was concluded by identifying few safety aspects that are required to be known while using natural, unprocessed honey

Quantitative analysis of mast cells in oral submucous fibrosis

Back ground: On the Indian subcontinent, the use of smokeless tobacco in various forms is very popular. Oral submucous fibrosis is a chronic condition of the oral mucosa, which results in a marked rigidity with progressive inability to open the mouth and has an increased risk of undergoing carcinomatous changes about four to eight percent. Objectives: The objective of this study was to evaluate whether early recognization and subsequent prevention of its transformation into an advanced stage would assist in early treatment of this condition. Method: This study was undertaken by retrieving the records and the paraffin blocks of the confirmed cases of 30 oral submucous fibrosis and 10 normal buccal mucosa as control. Two sets of sections were obtained. One set subjected to Toluidine Blue staining and the other set subjected to Hematoxylin & Eosin. Result: The mast cell response in oral sub mucous fibrosis was reported to be high in the early stages where the reaction of the tissue to the irritant is strong. As the disease advances tissue becomes less reactive, gets hyalinized and occasionally shows degeneration where the mast cells are reduced and are often even fewer than in the normal mucosa. Conclusion: Since this disease is known to be prevalent in India due to the habits, the study was conducted to observe different histopathological features and the occurrence of mast cells in various grades of Oral Sub Mucous fibrosis. This study also emphasizes the role of mast cells and its concentration in different grades of OSMF

A Simple and Green Protocol for the Synthesis of 3,4-dihydropyrimidin-2(1H)-ones Using 11-Molybdo-1-vanado phosphoric Acid as a Catalyst Under Ultrasound Irradiation

A one-pot three-component reaction of ethyl acetoacetate, aldehydes and urea has efficiently been carried out in the presence of 11-molybdo-1-vanadophosphoric acid in ethanol at room temperature under ultrasound irradiation to form the corresponding 3,4-dihydropyrimidin 2(1H)-ones in high yields. The 11-molybdo-1-vanadophosphoric acid (H4PMo11V1O40) was prepared and characterized by FT-IR spectroscopy, TG-DTA analysis and XRD analysis techniques. The presence of Keggin structure and incorporation of vanadium into the Keggin structure of synthesized H4PMo11V1O40 catalyst was confirmed by FT-IR and powder XRD analysis techniques. TG-DTA analysis results indicated that H4PMo11V1O40 catalyst was thermally stable up to the temperature 434 °C. The present catalytic system is recyclable and can be reused without greater loss of reactivity. DOI: http://dx.doi.org/10.17807/orbital.v11i5.1423   </p

Fibrolipoma - A Rare Intraoral Tumor: A Case Report

Lipomas are the most common benign mesenchymal tumors, developing in any location where fat is normally present. They develop mostly in the subcutaneous tissues but also could develop in deeper tissues. These most commonly occur in the fifth or sixth decade of life, are multiple in 5% of patients and are uncommon in children. However in the oral cavity this is a relatively rare tumor. When present in the oral cavity these lipomas can present with difficulties in speech and mastication. They predominantly affect the buccal mucosa followed by the lip and tongue. We present a case report of a young female patient diagnosed with a fibro-lipoma in the hard palate

Envirocat EPZG Mediated Synthesis of 3,4-Dihydropyrano[c]chromene Derivatives Under Microwave Irradiation in Solvent-free Conditions

A Envirocat EPZG mediated method is developed for the synthesis of 3,4‐dihydropyrano[c]chromene derivatives under microwave irradiation by three component cyclocondensation of 4‐hydroxycoumarin, malononitrile and aromatic aldehydes. The process has been carried out under solvent-free conditions in the presence of very small amount of Envirocat EPZG. Use of ecofriendly readily available catalyst and green reaction media makes this methodology simple, safe, and cost effective. Mild reaction conditions, easy workup procedure, excellent yields and short reaction times are some remarkable features of this work. DOI: http://dx.doi.org/10.17807/orbital.v13i1.1517 </p

Association of the MMP1–1607 1G>2G, MMP3-1171 5A>6A and MMP9-1562 C>T genotypes with breast cancer susceptibility and clinicopathological characteristics.

<p>Association of the MMP1–1607 1G>2G, MMP3-1171 5A>6A and MMP9-1562 C>T genotypes with breast cancer susceptibility and clinicopathological characteristics.</p