Volume flexible multi items inventory system with imprecise environment

This paper addresses a multi items volume flexible system for time dependent decaying items with the concept of machine breakdown and imprecise environment. In this study, partially backlogged shortages have been discussed. All the costs are fuzzified with signed distance method. Numerical examples are given to illustrate the theoretical results and sensitivity analysis is given to validate the results for various parameters

Bidirectional Transmission in TWDM Optical Access Network with Tunable Wavelength ONU

In this paper, a novel configuration for bidirectional hybrid time and wavelength division multiplexing (TWDM) optical access network is presented that fulfills the growing broadband requirements of next generation 5G customers. A purely passive system module is suggested for 512 subscribers that can communicate at a line rate of 240 Gbps in downlink and 160 Gbps in uplink over the common fiber cable. Shared network infrastructure helps in amortization of the installation and recurring operational expenses. Subscriber optical network unit (ONU) consists of tunable wavelength transmitter that can adjust uplink channel on the instructions of the medium access control layer (MAC). Improved Bandwidth Optimization Hybrid Scheduling Algorithm (BOHSA1) is implemented in the network to reduce the wastage of time slots per channel that helps in improving the channel utilization. The demonstrated architecture is extensively investigated to know the impact of diverse encoding scheme; photo-detector and electric filter have on the network performance

Bidirectional Transmission in TWDM Optical Access Network with Tunable Wavelength ONU

909-913In this paper, a novel configuration for bidirectional hybrid time and wavelength division multiplexing (TWDM) optical access network is presented that fulfills the growing broadband requirements of next generation 5G customers. A purely passive system module is suggested for 512 subscribers that can communicate at a line rate of 240 Gbps in downlink and 160 Gbps in uplink over the common fiber cable. Shared network infrastructure helps in amortization of the installation and recurring operational expenses. Subscriber optical network unit (ONU) consists of tunable wavelength transmitter that can adjust uplink channel on the instructions of the medium access control layer (MAC). Improved Bandwidth Optimization Hybrid Scheduling Algorithm (BOHSA1) is implemented in the network to reduce the wastage of time slots per channel that helps in improving the channel utilization. The demonstrated architecture is extensively investigated to know the impact of diverse encoding scheme; photo-detector and electric filter have on the network performance

House of Music: London Studio

The graduation project ‘House of Music, London’ expands upon the idea of designing a concert hall next to the Barbican complex at the existing site of Museum of London. The concert space is envisioned as a viable opportunity to bring together leisure and recreation, but also a lucrative public realm where various social groups can initiate interaction. The base of the building is imagined as a thick plinth. The intimidating thick plinth as a mass is mediated with arches and vaults in various axes to open it to the adjacent streets. To augment this feeling of an over-arching mass, concrete was used to materialize the external façade. This arrangement of porous and non-porous had to also be translated into the spatial arrangement of the plan. To achieve this, various programs were first organized and then categorized as solids and voids. The solids are treated as functions in the building and the voids are the transition spaces designed like the vaults and arches. The project is about monochromatic tectonic nature of the architecture with a subtle introduction of color through the use of carpet, furniture or even people. The building is inherently in grey concrete while color is added with the bright carpet flooring and the furniture. Through this process, it also became visible that the festive nature of the building truly comes from the users who add color to the monochromatic architecture. In terms of materialization, silver stained wooden interiors were given to the concert hall. The silver tones complement the grey shades and the wood helps to functionally resolve the acoustics. Again, in order to balance the effect of the silver walls, bright colour chairs are used for the seating. Architecture, Urbanism and Building Sciences | Interiors Buildings Citie

Geriatric assessment in the older adult with genitourinary cancer: A narrative review.

Genitourinary (GU) cancers including bladder, prostate, and kidney cancers affect older adults with a higher prevalence compared to younger adults. GU cancer treatment is associated with poorer outcomes in older adults compared to their younger counterparts. To better identify and support older adults receiving cancer care, oncologic societies recommend the use of a geriatric assessment (GA) to guide management. However, little is known about the implementation and usefulness of the GA in older adults with GU cancers. We performed a narrative review to investigate the utility of the GA in older adults with GU cancers and propose strategies to optimize the real-world use of the GA. Here, we describe a framework to incorporate GA into the routine cancer care of older adults with GU cancers and provide several implications for future research

Autoimmune Disease in Patients With Advanced Thymic Epithelial Tumors.

INTRODUCTION: Paraneoplastic autoimmune diseases (ADs) are a hallmark of thymic epithelial tumors (TETs) and affect treatment management in patients with advanced-stage tumors, yet the risk factors for development of AD in advanced TET remain poorly understood. METHODS: All patients with advanced TET treated at Stanford University between 2006 and 2020 were included. Charts were retrospectively reviewed for the presence of AD, demographic information, and treatment history. Next-generation sequencing was performed on available TET tissue. Multivariate regression was used to evaluate variables associated with AD. RESULTS: A total of 48 patients were included in the analysis with a median follow-up of 5.4 years. One-third (n = 16, 33%) were diagnosed with having ADs, with 28 distinct ADs identified. The only significant difference observed in the AD cohort compared with the non-AD cohort was a higher proportion of thymoma histotype (81% versus 47%, p = 0.013). The most common AD events were myasthenia gravis (n = 7, 44%) followed by pure red cell aplasia (n = 5, 31%). In the multivariate models, there were no independent factors associated with AD, either at TET diagnosis or subsequent to TET diagnosis. Genomic data were available on 18 patients, and there were no overlapping mutations identified in the nine patients with AD. CONCLUSIONS: ADs are common in patients with advanced TETs. Prior total thymectomy does not affect the development of subsequent AD. Patients who developed AD other than myasthenia gravis were more likely to do so several years after TET diagnosis. Additional work, including multiomic analyses, is needed to develop predictive markers for AD in advanced TET

Association of nutrition with psychological health and quality of life among older adults with advanced cancer

Research Funding U.S. National Institutes of Health U.S. National Institutes of Health Background: Impaired nutrition is associated with greater treatment toxicity and reduced overall survival in patients with advanced cancer. We aimed to evaluate the association of impaired nutrition with psychological health and quality of life among older adults with advanced cancer who were starting cancer treatment with palliative intent. Methods: This secondary analysis was performed on baseline data from a nationwide cluster randomized clinical trial (ClinicalTrials.gov identifier: NCT02107443; PI: Mohile; funding NCI UG1CA189961). Adults age ≥70 with advanced cancer and≥1 geriatric assessment impairment were enrolled from 2014 to 2017. Patients with BMI \u3c 21 kg/m2, \u3e 10% involuntary weight loss in the past 6 months, or Mini Nutritional Assessment Short Form (MNA-SF) score of ≤11 were considered to have impaired nutrition. We used separate multivariable linear regressions to evaluate the association of impaired nutrition with each measure of psychological health and quality of life, which included Geriatric Depression Scale (GDS-15, range 0-15), Generalized Anxiety Disorder-7 (GAD-7, range 0-21), NCCN Distress Thermometer (NCCN DT, range 0-10) and Functional Assessment of Cancer Therapy-General (FACT-G, range 0-108). Analyses were adjusted for baseline patient demographics, clinical characteristics, and geriatric assessment. Results: Among 541 patients, mean age was 77 (range 70-96) and 60% had impaired nutrition. Among the 326 patients with impaired nutrition, 95% had MNA-SF ≤11, 23% had \u3e 10% weight loss in the last six months, and 20% had BMI \u3c 21 kg/m2. Mean baseline GDS-15 was 3.1 (standard deviation [SD] 2.7), GAD-7 was 2.9 (SD 4.0), NCCN DT was 2.9 (SD 2.7), and FACT-G was 80 (SD 14). In the adjusted model, compared to those with normal nutrition, older adults with impaired nutrition had greater depression (mean 0.65 points higher on the GDS-15, p \u3c 0.01) and lower quality of life (mean 6.0 points lower on the FACT-G, p \u3c 0.01). There was insufficient evidence of an association between nutrition and anxiety (β = 0.67, p = 0.06) or distress (β = 0.26, p = 0.28). Conclusions: Recognition of malnutrition by oncology providers is crucial for older adults with advanced cancer. Impaired nutrition is associated with greater depression and lower quality of life among older adults with advanced cancer. Tailored resources to improve psychological health and quality of life are needed to support older adults with impaired nutrition receiving cancer treatment