Silicosis, Tuberculosis (tb) And Hiv/aids: The Triple Epidemic Among Gold Mineworkers In South Africa (literature Review And Policy Analysis)

The scourge of the triple epidemic of silicosis, tuberculosis (TB) and HIV/AIDS has plagued the South African gold mineworkers, with black mineworkers in particular, for over two decades now. Factors such as oscillating migration patterns, hazardous working conditions, and crowded living arrangements allow for the perfect conditions needed to sustain and amplify the epidemic within this population. The objective of this thesis is to provide a detailed review of the epidemiological literature regarding the different aspects of the silicosis, TB and HIV epidemic in South Africa, followed by an in-depth analysis of the current policy response, and its implications for directing the next phase of response to this epidemic. Review of the epidemiological literature provides strong and cogent evidence for the rapid and concomitant increase in the incidence and prevalence of silicosis and TB among gold mineworkers in South Africa over the last two decades, and shows that silica dust exposure is an independent risk factor for TB even among gold mineworkers without silicosis, thereby putting miners at increased risk of TB even after the exposure to silica dust has ceased. The policy analysis shows that there are serious gaps in research, policy and implementation regarding the approach and strategy to address the epidemic so far, especially with the steady decline in research expenditure on mining-related occupational health and safety research over the last few years. There has also been a wide-ranging failure to reduce silica dust exposure levels in gold mines, resulting in the failure to prevent new cases of silicosis among mineworkers

Impact of 2016th-year Demonetization on Banks in India

Demonetization is a monetary step in which a particular series of banknotes render invalid either by the government or by issuing authority of the nation to eliminate the undeclared income. It is a process in which certain units of currency notes will not be remains as legal tender. On November 8, 2016, government demonetize old ₹ 500 and ₹1000 banknotes which were 86% (15.41) trillion in total circulation to curb the black money, wipe off the fake currency, and make a halt in corruption. This move shook all the corners of the economy in which the banking sector was significantly affected. It gave a positive impact on the financial statements of banks, as the deposits were increased, the net earnings of the bank were also increase. Therefore, the study has been conducted to throw the light on the impact of demonetization on banks, primary data have been collected for the of Pre and Post demonetization period

Impact of Demonetization on the Various Sectors of Indian Economy

Demonetisation is an act of cancelling the legal tender status of a currency unit. It is a process when the government pulled out a unit of currency from the total circulation of the economy. The concept of demonetisation is not new, at first French used demonetisation then after most of the countries has adopted demonetisation to clean up the economy from corruption and inflation. India has adopted demonetisation three times: At first in January 1946 when RBI demonetised Rs. 1000 and Rs. 10000 currency notes. and again in  1978 by Moraji Desai of Rs. 1000, 5000, 10000 banknotes were demonetised and both demonetisation were held to eradicate black money. But the term Demonetisation became familiar on 8 November 2016 when P.M. Mr Narendra Damodar Das Modi announced Rs.500 and Rs.1000 currency notes will be no longer as legal tender status from the past midnight to unearth the corruption, black money and terror funding. Therefore this research paper is an attempt to throw the light on effect of demonetisation launched by NDA Government

A functionally conserved boundary element from the mouse HoxD locus requires GAGA factor in Drosophila

Hox genes are necessary for proper morphogenesis and organization of various body structures along the anterior-posterior body axis. These genes exist in clusters and their expression pattern follows spatial and temporal co-linearity with respect to their genomic organization. This colinearity is conserved during evolution and is thought to be constrained by the regulatory mechanisms that involve higher order chromatin structure. Earlier studies, primarily in Drosophila, have illustrated the role of chromatin-mediated regulatory processes, which include chromatin domain boundaries that separate the domains of distinct regulatory features. In the mouse HoxD complex, Evx2 and Hoxd13 are located ~9 kb apart but have clearly distinguishable temporal and spatial expression patterns. Here, we report the characterization of a chromatin domain boundary element from the Evx2-Hoxd13 region that functions in Drosophila as well as in mammalian cells. We show that the Evx2-Hoxd13 region has sequences conserved across vertebrate species including a GA repeat motif and that the Evx2-Hoxd13 boundary activity in Drosophila is dependent on GAGA factor that binds to the GA repeat motif. These results show that Hox genes are regulated by chromatin mediated mechanisms and highlight the early origin and functional conservation of such chromatin elements

Racial and Ethnic Disparities in Teenage Pregnancy: Perspectives from Teens and Community Members in Connecticut

BACKGROUND: Teenage pregnancy has negative consequences for mother and baby, for example, high school drop out and low birth weight, respectively. Overall, Connecticut (CT) has one of the lowest teen pregnancy rates in the United States. However, a great disparity exists between whites and other ethnicities. Black teens are 4 – 5 times as likely to give birth than their white counterparts and Latino teens are 8 times as likely to give birth as white teens. Planned Parenthood of Southern New England (PPSNE) has identified this disparity and seeks the assistance of our research team in developing targets and programming to prevent teen pregnancies. METHODS: Teen focus groups and key informant interviews were used to examine barriers to teen birth reduction among ethnic minorities in three cities (Hartford, New London, and New Haven, CT). We develop ed an action plan for PPSNE that identifies potential barriers to preventing teenage pregnancy, identifies potential community partnerships , and includes population attributable risk estimation s to demonstrate potential decreases in teen pregnancy by race/ethnicity. RESULTS: Three focus group sessions were completed with a total of 22 adolescent participants (14 females and 8 males) between the ages of 15 and 21. Focus group respondents attributed teen pregnancy to desire for pregnancy, perceived invincibility, lack of knowledge/sexual education and family precedent. The teens indicated that a more substantial presence from peer educators and improved sex education in schools could have an impact on reducing teen pregnancy in minorities. Two key informant interviews with community organization staff members revealed overlapping themes of inadequate education, inadequate support to stay in school, and lack of support for pregnancy prevention programs. Overall, respondents had positive perceptions of Planned Parenthood. IMPLICATIONS: Results from this research will provide information to PPSNE regarding the necessary steps to design programs aimed at reducing disparities in teen birth rates in Connecticut. By focusing on Black and Latino teens, we hope to facilitate the development of culturally competent initiatives that result in the elimination of disparities surrounding teen births. Partnership development between PPSNE and community organizations can foster successful and sustainable programs in our populations of interest.https://elischolar.library.yale.edu/ysph_pbchrr/1038/thumbnail.jp

Epigenetic profile of the euchromatic region of human Y chromosome

The genome of a multi-cellular organism acquires various functional capabilities in different cell types by means of distinct chromatin modifications and packaging states. Acquired during early development, the cell type-specific epigenotype is maintained by cellular memory mechanisms that involve epigenetic modifications. Here we present the epigenetic status of the euchromatic region of the human Y chromosome that has mostly been ignored in earlier whole genome epigenetic mapping studies. Using ChIP-on-chip approach, we mapped H3K9ac, H3K9me3, H3K27me3 modifications and CTCF binding sites while DNA methylation analysis of selected CpG islands was done using bisulfite sequencing. The global pattern of histone modifications observed on the Y chromosome reflects the functional state and evolutionary history of the sequences that constitute it. The combination of histone and DNA modifications, along with CTCF association in some cases, reveals the transcriptional potential of all protein coding genes including the sex-determining gene SRY and the oncogene TSPY. We also observe preferential association of histone marks with different tandem repeats, suggesting their importance in genome organization and gene regulation. Our results present the first large scale epigenetic analysis of the human Y chromosome and link a number of cis-elements to epigenetic regulatory mechanisms, enabling an understanding of such mechanisms in Y chromosome linked disorders

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM