A Privacy-Preserving Framework for Large-Scale Content-Based Information Retrieval Using K-Secure Sum Protocol

We propose a privacy protection framework for large-scale content-based information retrieval. It offers two layers of protection. To begin with, robust hash values are utilized as quiries to avoid uncovering unique content or features. Second, the customer can choose to exclude certain bits in a hash values to further expand the ambiguity for the server. Due to the reduced information, it is computationally difficult for the server to know the customer's interest. The server needs to give back the hash values of every single possible to the customer. The customer performs a search within the candidate list to locate the best match. Since just hash values are exchanged between the client and the server, the privacy of both sides is ensured. We present the idea of tunable privacy, where the privacy protection level can be balanced by policy. It is acknowledged through hash-based piecewise inverted indexing. The thought is to gap a highlight vector into pieces and list every piece with a sub hash value. Each sub hash value is connected with an inverted index list. The framework has been broadly tested using a large scale image database. We have assessed both retrieval performance and privacy-preserving performance for a specific content identification application. Two unique developments of robust hash algorithms are utilized. One depends on random projections; the other depends on the discrete wavelet transform. Both algorithm exhibit satisfactory performances in comparison with state-of-the-art retrieval performances. The outcomes demonstrate that the privacy upgrade somewhat enhances the retrieval performance. We consider the majority voting attack for evaluating the query category and identification. The test results demonstrate that this attack is a threat when there are close duplicities, yet the achievement rate diminishes with the quantity of discarded bits and the number of distinct items

Neurobrucellosis: a case report

Neurologic involvement of brucellosis is common but exact prevalence of it is unknown due to difficulty in diagnosis and inadequate reporting all over the world. Neurologic involvement may manifest as chronic meningitis, lymphocytic meningoencephalitis, a variety of cranial nerve deficits, or ruptured mycotic aneurysms. We report a case of young male who had history of fever and headache on and off for 2 years and later developed signs of meningitis, lateral rectus palsy, altered sensorium and bilateral papilledema. He did not respond to anti-tubercular therapy and antibiotics. CT scan and MRI brain were normal. He had hepato-splenomegaly with small hypoechoic lesions in the spleen. CSF culture grew gram negative bacilli. Brucella IgG antibodies in serum by EIA 7, IgM negative, Brucella antigen titer was positive, 1:160. Patient received inj. streptomycin 0.75 g for 21 days and doxycycline 100 mg twice daily doxycycline for 6 weeks. The complete improvement in patient’s condition after a long lasting illness motivated authors to report this case. Delay or failure in diagnosis of this treatable disease may lead to significant morbidity and mortality so high index of suspicion should be kept in such cases

PHYTOPHARMACOLOGICAL REVIEW OF KNEMA ATTENUATA (HOOK F. AND THOMSON) WARB

Knema attenuata, a member of Myristicaceae family and commonly known to world as ‘wild nutmeg’ is broadly used in folk medicine for treating ailments such as jaundice, chronic fever, inflammations, spleen disorders, breathing disorders and impaired taste sensation. This review article aims to compile all the updated information on the phytochemical and pharmacological activities of plant Knema attenuata. Studies indicate that different parts such as aril, seed and stem bark of the plant is rich in phenolics, flavonoids, tannins, steroids, terpenes, resins and glycolipids. Moreover, stem bark of Knema attenuata contains a lignan ‘attenuol’ with diverse pharmacological activities. In addition, different extracts of plant parts have been found to possess various pharmacological activities such as antioxidant, antifungal, larvicidal, analgesic, anti-inflammatory, antihyperlipidemic, and hepatoprotective activities. More research on phytochemical composition and therapeutic implications are recommended

Superior Supercapacitors based on Biowaste Materials

Carbon nano spheres derived from Allium cepa were synthesized at different temperatures in a one-step pyrolysis process for supercapacitor electrodes. Obtained carbon nano spheres were analyzed using SEM, FTIR, BET and XRD. The nano materials were fabricated into conducting electrodes for cyclic voltammetry, constant current charge-discharge and electrochemical impedance spectroscopy studies. All the studies were done in 3.0 M KOH electrolyte. Specific capacitance from charge discharge experiments were found to be 132.03 F/g and 149.49 F/g for nano materials synthesized at 500ºC and 600ºC respectively. Obtained values suggest a way forward in producing a green electrode for commercial applications

Automated Speaker Independent Visual Speech Recognition: A Comprehensive Survey

Speaker-independent VSR is a complex task that involves identifying spoken words or phrases from video recordings of a speaker's facial movements. Over the years, there has been a considerable amount of research in the field of VSR involving different algorithms and datasets to evaluate system performance. These efforts have resulted in significant progress in developing effective VSR models, creating new opportunities for further research in this area. This survey provides a detailed examination of the progression of VSR over the past three decades, with a particular emphasis on the transition from speaker-dependent to speaker-independent systems. We also provide a comprehensive overview of the various datasets used in VSR research and the preprocessing techniques employed to achieve speaker independence. The survey covers the works published from 1990 to 2023, thoroughly analyzing each work and comparing them on various parameters. This survey provides an in-depth analysis of speaker-independent VSR systems evolution from 1990 to 2023. It outlines the development of VSR systems over time and highlights the need to develop end-to-end pipelines for speaker-independent VSR. The pictorial representation offers a clear and concise overview of the techniques used in speaker-independent VSR, thereby aiding in the comprehension and analysis of the various methodologies. The survey also highlights the strengths and limitations of each technique and provides insights into developing novel approaches for analyzing visual speech cues. Overall, This comprehensive review provides insights into the current state-of-the-art speaker-independent VSR and highlights potential areas for future research

Apert syndrome (Acrocephalosyndactyly): a case report

Apert syndrome is named for the French physician. Eugene Apert in 1906 described the syndrome acrocephalosyndactylia. It is a rare autosomal dominant disorder characterized by craniosynostosis, craniofacial anomalies, and severe symmetrical syndactyly of the hands and feet (i.e. cutaneous and bony fusion refers to webbing of fingers and toes). Apert syndrome is characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face. In addition, a varied number of fingers and toes are fused together (syndactyly). Most cases of Apert syndrome are sporadic, may result from new mutations in the gene. The purpose of this paper is to report a case of Apert syndrome in a female fetus of 30 weeks with asymmetrical skull confirmed by prenatal ultrasonography. Pregnancy was terminated and fetus was submitted for detailed autopsy in anatomy dissection hall. The findings and review of literature were presented in this article

Prune belly syndrome (sequenze): a case report

The Prune Belly syndrome (PBS) also known as Eagle Barret syndrome is a rare disorder. It is an abdominal muscles deficiency syndrome characterized by a Triad syndrome i.e. deficiency of abdominal wall muscles, failure of testicular descent and dilation of the urinary tract. This syndrome has derived its name from the wrinkled prune appearance of the abdominal wall. Prune Belly syndrome is a rare anomaly seen in one in 35,000-50,000 live births. It occurs in all races. Prune Belly syndrome almost exclusively occurs in males (M:F, 20:1). The diagnosis can be made in utero by ultrasonography at 21 weeks of gestation or in the Neonate with characteristic clinical findings.                                                                                 The present case was a dead male fetus of 20 weeks of gestation sent to Anatomy department after Medical termination of pregnancy, due to congenital anomalies identified in routine ultrasound examination during antenatal checkup

A prospective observational study of drug usage in the management of snake bite patients and their outcome in a tertiary care teaching hospital

Background: The objectives of the study were to assess the pattern of management of snakebite especially with respect to use of anti- snake venom and other supportive treatment given and to assess the effect of anti-snake venom on different types of snakebite and to assess their outcome.Methods: A prospective observational study was conducted over a period of 6 months, after getting approval from Institutional Ethics committee. Total of 144 snake bite patients were analysed for six months duration for use of anti-snake venom and other supportive treatment in their management and were assessed for their outcome like recovery, morbidity and mortality.Results: Out of 144 snake bite patients analysed, 71.5% had poisonous type and 28.4% had non- poisonous type of snake bite. Among the total number of snakebites, 47.2% were unknown type and among the known type 25% were viper, 13.2% cobra, 7.6% krait, 6.3% sea snake and 0.7% green snake. Anti-snake venom (ASV) was given to 62 patients depending on severity, of which, 22 patients developed reaction to ASV. Patient with reaction to ASV were treated with corticosteroid and antihistamine injection. Morbidity was seen in 29.1% of patients who developed either cellulitis or gangrene of bitten area, which was more commonly seen among viper bite patients (54.7%).Conclusions: Snakebite is one of the commonest tropical diseases leading to envenomation and poisoning especially in rural areas of tropical countries which has to be treated as early as possible to prevent complications. Majority of the cases in our study were of viper bite and most of them have recovered after treatment

Enhancing patient safety: leveraging artificial intelligence-powered electronic medical records for effective drug-drug interaction nudge in real-world prescribing practices

Background: Concurrent prescriptions of various medications may lead to unfavorable and unanticipated potential drug-drug interactions. Hence, the elimination of drug-drug interactions is a key aspect of delivering a coherent treatment regime. In response to this concern, HealthPlix, one of India's largest AI-powered electronic medical record providers, introduced a drug-drug interaction nudge feature in June 2022, providing a proactive solution for physicians to address potential interactions between incompatible drugs. This study aimed to elucidate the role of electronic medical records in identifying and managing drug interactions and the advantages of interaction nudges for doctors in prescribing appropriate medications. Methods: An observational retrospective study was conducted using data obtained from HealthPlix, containing two or more drugs, written for patients older than 18 years. Results: In an average of 1.9 million patient visits analyzed, the interaction visits were observed to be 1.2 million. An average of 185,745 interactions were observed during the study period. For all observed interactions, an average of 72,383 molecules were removed. These results provide insights into the efficiency of HealthPlix in abrogating interactions and illustrate the tangible benefits of nudges in modifying prescription practices. Conclusions: The above results illustrate the effectiveness of drug-drug interaction nudges as a clinical decision support tool integrated into HealthPlix, marking a significant advancement in Indian healthcare. This unique feature contributes to reducing the frequency of potent drug interactions, showcasing its potential to enhance patient safety and improve the quality of healthcare delivery

REVERSED PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT AND VALIDATION OF ATORVASTATIN IN BULK DRUG AND FORMULATION

Objective: To develop and validate a simple, selective, rapid, precise, and accurate high performance liquid chromatographic (HPLC) method fordetermination of atorvastatin in bulk and its pharmaceutical formulation product.Method: Reversed phase-HPLC (RP-HPLC) method was performed by a mobile phase consisting mixture of methanol and ammonium acetate buffer(pH 4.5) in the proportion 60:40 v/v. A ZORBAX Eclipse plus C(4.6 mm × 100 mm, 3.5 μ) column was used as a stationary phase. HPLC analysis ofatorvastatin was carried out at a wavelength of 241 nm with a flow rate of 1 ml/minute.18 Results: The linear regression analysis data for the calibration curve showed a good linear relationship with a correlation coefficient 0.9984. Thelinear regression equation was y=3726540.2x+27390388.1. This was found to give a sharp peak of atorvastatin at a retention time of 2.77 minutes.Validation parameters were evaluated for the method according to the ICH (Q2R1) guidelines. The limit of detection and limit of quantification for themethod were 0.6721 μg/mL and 1.9989 μg/mL, respectively. The % relative standard deviation values for intra-day precision and inter-day precisionwere found to be 0.31% and 0.30%, respectively. An accuracy of the method was determined through recovery studies which were found to be within97.57-102.22%.Conclusion: The method was validated for system suitability, accuracy, precision, robustness, and ruggedness. The precision, accuracy, sensitivityshort retention time and composition of the mobile phase indicated that this method is better than the earlier methods developed for the quantificationof atorvastatin.Keywords: Atorvastatin, Reversed phase-high performance liquid chromatographic method development, Validation