Due casi di malaria diagnosticati incidentalmente con un analizzatore ematologico

no abstrac

Esperienza pilota di accreaditamento di un centro per la diagnosi della trombosi e la sorveglianza delle terapie antitrombotiche

No abstrac

Quality of therapy with dicoumarols, new oral anticoagulants, and role of anticoagulation clinics [Qualità della terapia con dicumarolici, nuovi anticoagulanti orali, e ruolo dei centri per la terapia anticoagulante]

Background.: For many decades dicoumarols are employed for prophylaxis and therapy of thromboembolic diseases. For some of these diseases new, efficacious, and safe oral anticoagulant drugs (NAO) are now available: dabigatran, rivaroxaban, apixaban. The Italian Agency for drugs (AIFA) regulates their refund by Public Health System. In non-valvular atrial fibrillation (FANV) a sufficient condition for repayment is a Time in Therapeutic Range (TTR) in dicumarols below 61% for rivaroxaban and 71% for dabigatran and apixaban. In our Anticoagulation clinic (centro FCSA 186, Federation of Anticoagulation clinics) we are following about 1000 patients in anticoagulant therapy (TAO); for about 350 more patients our Laboratory Service only assays the prothrombin time (PT), the patients being followed by their own family physicians. From regional database we estimate that about 11400 patients are taking TAO for FANV in our territory (ULSS 20), 11% of them followed by FCSA, and about 113000 in our region (Veneto), 20% followed by FCSA

Individual-oriented Model Crowd Evacuations Distributed Simulation

AbstractEmergency plan preparation is an important problem in building design to evacuate people as fast as possible. Simulation exercises as fire drills are not a realistic situation to understand people behaviour. In the case of crowd evacuations the complexity and uncertainty of the systems increases. Computer simulation allows us to run crowd dynamics models and extract information from emergency situations. Several models solve the emergency evacuation problem. Individual oriented modelling allows to give behaviour rules to the individual and simulate interactions between them. Due to variation on the emergency situations results have to be statistically reliable. This reliability increases the computing demand. Distributed and parallel paradigms solve the performance problem. In the present work we present a crowd evacuations distributed simulator. We implemented two versions of the model. One using Netlogo and another using C with MPI. We chose a real environment to test the simulator: pavilion 2 of Fira de Barcelona building, able to hold thousands of persons. The distributed simulator was tested with 62,820 runs in a distributed environment with 15,000 individuals. In this work we show how the distributed simulator has a linear speedup and scales efficiently

Dabigatran and laboratory tests [Dabigatran e analisi di laboratorio]

New oral anticoagulants (i.e., dabigatran, rivaroxaban, apixaban) are now available. In using these drugs, routine monitoring of laboratory coagulation tests is not recommended. In some clinical conditions, however, a laboratory evaluation of hemostatic balance may be useful. Tests suggested for laboratory monitoring of dabigatran treatment are thrombin time on undiluted (TT) or diluted (dTT) plasma and ecarin clotting time. On 30 patients taking dabigatran for non valvular atrial fibrillation, we assayed dabigatran levels by dTT, also performing prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and TT. In patients taking dabigatran etexilate 110 mg bis in die and 150 mg bis in die, dTT mean results (10th-90th percentile) were 97 (32-152) and 94 (33-189) \u3bcg/L, respectively. In dTT range from 13 to 60 \u3bcg/L and >60 \u3bcg/L, we obtained 27% and 58% prolonged PT, 64% and 95% prolonged APTT, and 100% and 100% prolonged TT, respectively, showing that for dabigatran TT is a useful screening test

PSEE: A Tool for Parallel Systems Learning

Programs for parallel computers of distributed memory are difficult to write, understand, evaluate and debug. The design and performance evaluation of algorithms is much more complex than the conventional sequential one. The technical know/how necessary for the implementation of parallel systems is already available, but a critical problem is in the handling of complexity. In parallel distributed memory systems the performance is highly influenced by factors as interconnection scheme, granularity, computing/communication ratio, algorithm topology, parallel languages, and operating system policies. Interaction between these factors is not easy to understand and often unpredictable. This paper presents the PSEE (Parallel System Evaluation Environment), an interactive graphical environment, which permits to study the behaviour of parallel distributed memory systems, as well as several enhancements to increase the goodness of this tool. PSEE is an easy-to-use environment that enables parallel distributed memory systems programmers take decisions about the behaviour program and parallel computer in terms such as scalability, tuning and performance of the underlying parallel machine