11 research outputs found
Increased Oral Dryness and Negative Oral Health-Related Quality of Life in Older People with Overweight or Obesity
This cross-sectional study was to evaluate the association between the oral health-related quality of life (OHRQoL) of older Thai people with obesity and oral health indicators. General and oral conditions were assessed. Oral dryness was determined using the Xerostomia Inventory-11 (XI-11) and clinical oral dryness score (CODS). OHRQoL was evaluated by the oral health impact profile (OHIP-14). Participants were aged 60–86 years; 73 (59.3%) were overweight or obese, and 50 (40.7%) were normal weight. Older patients with obesity had almost four times the rate of hypertension (OR = 3.59; 95%CI:1.34–9.60; p = 0.002), more missing teeth (p = 0.025), and higher CODS (p = 0.014) than those without obesity. The total XI-11 scores were positively associated with the total CODS, after adjusting for BMI (r = 0.267, p = 0.003). Those with obesity had almost three times the tendency for a negative OHRQoL compared with the non-obese (OR = 2.73; 95%CI:1.12–6.71; p = 0.04). After adjusting for all related factors, the chances of predicting an OHIP-14 score of four based on obesity and total XI-11 score were 4.42 (95%CI:1.57–12.47; p = 0.005) and 1.11 (95%CI:1.02–1.20; p = 0.013), respectively. Obesity had an increasingly undesirable negative impact on the OHRQoL of older Thai people and was influenced by BMI and oral dryness
Increased Plasma Osteocalcin, Oral Disease, and Altered Mandibular Bone Density in Postmenopausal Women
Levels of anti-periodontopathic bacteria IgG antibody and CRP according to the presence or absence of MS and severe periodontitis.
<p>Plasma IgG titers to <i>A</i>. <i>actinomycetemcomitans</i> were lower in patients with MS than in healthy participants, regardless of periodontal disease status (A). While plasma IgG titers to <i>P</i>. <i>gingivalis</i> were significantly higher in individuals with severe periodontitis than those without in both groups of healthy participants and MS patients (B), plasma IgG titers to <i>P</i>. <i>intermedia</i> did not show consistent findings with MS and periodontal status (C). CRP levels increased continuously from healthy participants without periodontitis to patients with MS and severe periodontitis (D).</p
PCR analysis of salivary <i>A</i>. <i>actinomycetemcomitans</i> and <i>P</i>. <i>gingivalis</i>.
<p>PCR analysis of salivary <i>A</i>. <i>actinomycetemcomitans</i> and <i>P</i>. <i>gingivalis</i>.</p
Association of MS and MS components with anti-periodontopathic bacteria IgG antibody and CRP levels as continuous measures adjusted for age, sex, BMI, smoking, alcohol consumption, education level, and exercise.
<p>Association of MS and MS components with anti-periodontopathic bacteria IgG antibody and CRP levels as continuous measures adjusted for age, sex, BMI, smoking, alcohol consumption, education level, and exercise.</p
Correlation between anti-periodontopathic bacteria IgG antibody and CRP levels.
<p>Correlation coefficient (r) analyses between anti-<i>P</i>. <i>gingivalis</i> antibody (A); anti-<i>P</i>. <i>intermedia</i> antibody (B) and anti-<i>A</i>. <i>actinomycetemcomitans</i> antibody; anti-<i>P</i>. <i>intermedia</i> antibody and anti-<i>P</i>. <i>gingivalis</i> antibody (C); anti-<i>A</i>. <i>actinomycetemcomitans</i> antibody (D); anti-<i>P</i>. <i>gingivalis</i> antibody (E); anti-<i>P</i>. <i>intermedia</i> antibody (F) and CRP; controlled for the absence or presence of MS.</p
Risk of MS by anti-periodontopathic bacteria IgG antibody and CRP levels.
<p>Risk of MS by anti-periodontopathic bacteria IgG antibody and CRP levels.</p
Characteristics of individuals [median (first, third quartile), mean±S.D. or n (%)] according to the presence or absence of MS and severe periodontitis.
<p>Characteristics of individuals [median (first, third quartile), mean±S.D. or n (%)] according to the presence or absence of MS and severe periodontitis.</p
Salivary and serum interleukin-17A and interleukin-18 levels in patients with type 2 diabetes mellitus with and without periodontitis.
OBJECTIVE:Interleukin (IL)-17A and IL-18 have been proposed to play important roles in periodontitis and type 2 diabetes mellitus (DM), but human data are conflicting. The present study aimed to investigate the roles of IL-17A and IL-18 in periodontitis and DM by measuring salivary and serum levels, respectively. MATERIALS AND METHODS:A total of 49 participants with type 2 DM and 25 control subjects without type 2 DM were recruited. A periodontal screening and recording (PSR) index (0, 1-2, 3, and 4) was used to classify whether these subjects had periodontitis. Salivary and serum IL-17A and IL-18 levels were measured by enzyme-linked immunosorbent assay. Multiple linear regression analyses were used to evaluate the associations between these cytokines and clinical parameters. RESULTS:Salivary IL-17A levels were not significantly different between patients with DM and controls, however, the levels were significantly higher in controls with periodontitis than those without periodontitis (p = 0.031). Salivary IL-17A levels were significantly associated with the PSR index (β = 0.369, p = 0.011). Multiple linear regression analyses revealed the association of salivary IL-18 levels and fasting plasma glucose (β = 0.270, p = 0.022) whereas serum IL-18 levels were associated with HbA1C (β = 0.293, p = 0.017). No correlation between salivary and serum levels of IL-17A and IL-18 was found. CONCLUSION:Salivary IL-17A was strongly associated with periodontitis, whereas salivary IL-18 was associated with FPG and serum IL-18 was associated with HbA1C. These results suggest the role of these cytokines in periodontal inflammation and DM