Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics

"This is the accepted version of the following article: Production and characterization of spray-dried theophylline powders prepared from fresh milk for potential use in paediatrics (2017). J Pharm Pharmacol, 69: 554–566, which has been published in final form at http://dx.doi.org/10.1111/jphp.12612 . This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]."Objective: This work evaluates the potential of using fresh milk to deliver theophylline to children.Methods: Theophylline–fresh milk systems were prepared using different solids ratios (0 : 1–1 : 0) and three fat contents in commercial milks (low, medium and high), which were spray-dried at different inlet air temperatures (Tinlet – 105, 130 and 150 °C). The process was evaluated for yield and the resulting powders for moisture content (MC), particle size and shape, density and wettability. Theophylline–milk potential interactions (differential scanning calorimetry (DSC) and FT-IR) and chemical (theophylline content) and microbiological stability of powders (shelf and in-use) were also evaluated.Key Findings: The production yield (13.6–76.0%), MC (0.0–10.3%) and contact angles in water (77.29–93.51°) were significantly (P < 0.05) affected by Tinlet, but no differences were found concerning the mean particle size (3.0–4.3 μm) of the different powders. The milk fat content significantly (P < 0.05) impacted on the density (1.244–1.552 g/cm3). Theophylline content remained stable after 6 months of storage, before extemporaneous reconstitution. After reconstitution in water, low-fat milk samples (stored at 4 °C) met the microbial pharmacopoeia criteria for up to 7 days. No theophylline–milk components interaction was observed.Conclusion: Spray-dried milk-composed powders may be used as vehicles for theophylline delivery in paediatrics following further characterization and in-vivo evaluation.info:eu-repo/semantics/publishedVersio

Physicochemical characteristics and in-vitro digestibility of talipot starch-lysine complexes formed by heat-moisture treatment and annealing

The study aimed to explore the physicochemical attributes and the in-vitro digestibility of talipot starch lysine complexes generated through heat moisture treatment (HMT) and annealing. Talipot starch is a nonconventional stem starch obtained from the trunk of Talipot palm. Lysine complexing considerably altered the physicochemical, pasting, and in-vitro digestibility of talipot starch, while the impact of HMT and annealing on the physicochemical and functional properties of the starch lysine complex is varied. The HMT of the starch lysine complex (HSL) had a paramount impact on starch functionalities than annealing of starch lysine complex (ASL). The HSL exhibited the lowest swelling ability, solubility, and retrogradation tendency. Similarly, the lysin complexing of talipot starch considerably reduced its in-vitro digestibility, and HSL exhibited higher resistant starch content

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Not AvailableExtraction of chitosan from deep-sea mud shrimp (Solenocera hextii) shell waste was conducted using a chemical method by altering the deacetylation times. The degree of deacetylation of extracted chitosan were 75.5 ± 0.36, 85 ± 0.38 and 87± 0.32 %, and the molecular weights were 263.95±1.16, 52.61± 0.44, and 5.15± 0.14 kDa respectively for CH-1.5, CH-3, and CH-6. Deacetylation time significantly influenced the structure and physico- chemical properties of chitosan. SEM results exposed smooth granular surface structure and XRD peaks obtained were identical with commercial chitosan. Deacetylation time for CH-3 was found optimum for commercial ex- traction of this natural biopolymer resource. Water binding and fat binding capacities of the extracted deep-sea mud shrimp chitosan were significantly higher than commercial chitosan from coastal shrimp and are suitable for many functional food applications.Not Availabl

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Not AvailableA cost-effective, portable, ultra violet assisted vertical re-circulatory depuration system (UVDC) was developed and its effect on microbiological, heavy metal and proximate composition of Black clam (Villorita cyprinoides) was investigated. The process of depuration was found to be effective in reduction of total viable count by 1.8 log cfu g-1. Escherichia coli were within the permissible limit and both Vibrio cholera and V. parahaemolyticus were absent. The concentrations of heavy metals (Cd, Pb and Cu) were found to decrease by 40.44%, 96.51% and 34.50% respectively at the end of 48 h of depuration in UVDC. Significant reduction in protein, lipid, ash and glycogen contents were observed after the depuration process. The portability and easy to assemble nature of the system further improves its applicability as an onsite depuration unit which could be effectively utilized by the small- scale clam fishers/farmers depending on polluted waters for enhancing their income and livelihood.Not Availabl

Contemporary insights into the extraction, functional properties, and therapeutic applications of plant proteins

Recently, plant proteins have received notable attention as food and medicine. Further, plant proteins are used to produce and isolate peptides to treat and prevent diseases in humans and animals. Plant proteins can be extracted from various sources, including industrial waste materials. Conventional and nonconventional methods are used to carry out the protein extraction. This review aims to overview the advanced protein extraction methods and the therapeutic functionalities of plant proteins and peptides. It was observed that the advanced protein extraction methods, i.e., ultrasound-assisted and microwave-assisted, are more efficient, eco-friendly, and less energy-consuming. The advanced protein extraction methods will help to face the challenges of using protein in food processing. In addition to the food functionality, plant-based proteins and peptides show potential therapeutic activity. It includes antidiabetic activity, anticancer activity, and anti-inflammatory activity. The pharmaceutical and nutraceutical industries will likely rely heavily on plant-derived peptides because of their benefits as functional ingredients