Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

Two new briarane-related diterpenoids, designated as excavatoids E (1) and F (2), were isolated from the cultured octocoral Briareum excavatum. The structures of compounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils

A Quantitative Analysis and Guideline of Data Streaming Accelerator in Intel 4th Gen Xeon Scalable Processors

As semiconductor power density is no longer constant with the technology process scaling down, modern CPUs are integrating capable data accelerators on chip, aiming to improve performance and efficiency for a wide range of applications and usages. One such accelerator is the Intel Data Streaming Accelerator (DSA) introduced in Intel 4th Generation Xeon Scalable CPUs (Sapphire Rapids). DSA targets data movement operations in memory that are common sources of overhead in datacenter workloads and infrastructure. In addition, it becomes much more versatile by supporting a wider range of operations on streaming data, such as CRC32 calculations, delta record creation/merging, and data integrity field (DIF) operations. This paper sets out to introduce the latest features supported by DSA, deep-dive into its versatility, and analyze its throughput benefits through a comprehensive evaluation. Along with the analysis of its characteristics, and the rich software ecosystem of DSA, we summarize several insights and guidelines for the programmer to make the most out of DSA, and use an in-depth case study of DPDK Vhost to demonstrate how these guidelines benefit a real application

Demystifying CXL Memory with Genuine CXL-Ready Systems and Devices

The high demand for memory capacity in modern datacenters has led to multiple lines of innovation in memory expansion and disaggregation. One such effort is Compute eXpress Link (CXL)-based memory expansion, which has gained significant attention. To better leverage CXL memory, researchers have built several emulation and experimental platforms to study its behavior and characteristics. However, due to the lack of commercial hardware supporting CXL memory, the full picture of its capabilities may still be unclear to the community. In this work, we explore CXL memory's performance characterization on a state-of-the-art experimental platform. First, we study the basic performance characteristics of CXL memory using our proposed microbenchmark. Based on our observations and comparisons to standard DRAM connected to local and remote NUMA nodes, we also study the impact of CXL memory on end-to-end applications with different offloading and interleaving policies. Finally, we provide several guidelines for future programmers to realized the full potential of CXL memor

Interleaved difference-frequency generation for microcomb spectral densification in the mid-infrared

With their compact size and semiconductor-chip-based operation, frequency microcombs can be an invaluable light source for gas spectrcoscopy. However, the generation of mid-infrared (mid-IR) frequency combs with gigahertz line spacing as required to resolve many gas spectra represents a significant challenge for these devices. Here, a technique referred to as interleaved difference-frequency generation (iDFG) is introduced that densifies the spectral line spacing upon conversion of near-IR comb light into the mid-IR light. A soliton microcomb is used as both a comb light source and microwave oscillator in a demonstration, and the spectrum of methane is measured to illustrate how the resulting mid-IR comb avoids spectral undersampling. Beyond demonstration of the iDFG technique, this work represents an important feasibility step towards more compact and potentially chip-based mid-IR gas spectroscopy modules

Interleaved difference-frequency-generation for mid-infrared microcomb spectral densification

Generation of mid-infrared combs (3.3 micron band) with GigaHertz line spacing is demonstrated by interleaved difference-frequency-generation. The method, applied to a 22 GHz repetition-rate microcomb, is useful for spectral densification of sparse microcomb spectra

Functional Effects of let-7g Expression in Colon Cancer Metastasis.

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment