Route Segment Level Analysis of Bus Safety Incidents

This paper analyzes collision and non-collision incidents that occurred on TriMet’s bus system over a near two-year period. The bus route network was decomposed into stop and line haul segments, and a typology of models was estimated from segment level incident, risk exposure, and roadway feature data. The frequency of non-collision incidents – mainly slips, trips and falls – was estimated to be primarily related to associated risk exposure variables. The frequency of collision incidents was also estimated to be related to risk exposure variables, as well as a number of roadway design variables. The findings serve as an initial step in informing the safety planning process

BIOMECHANICAL ANALYSIS A SEQENCE OF ANGULAR VELOCITY AND COORDINATED MUSCLES ACTIVITY DURING BASEBALL HITTING

The purpose of this study was to analyse a sequence of rotations and coordinated muscles activities of upper body. Using kinematic and EMG data from 3 recreational university baseball players participating in this study, we computed the angular velocity of trunk, pelvis, bat and trunk-pelvis rotation angle and PMT of upper body muscles. Trunkpelvis rotation angle was 22 ° before the bat-ball contact. The pelvis, trunk, and bat showed a sequence of angular velocity beginning with the hip, followed by the trunk, and end tip of the bat. Additionally, PMT of upper body muscles generated right pectoralis major(1.03 sec.), right external oblique(1.11 sec.), left thoracloumbar fasci(1.12 sec.), left external oblique(1.13 sec.), right latissimus dorsi(1.15 sec.), left latissimus dorsi(1.16 sec.), right thoracloumbar fascia(1.16 sec.), left pectoralis major(1.25 sec.), on at a time during baseball hitting motion. PMT of upper body muscles were related to the shifting and rotating of body segment and this action can be considered the coordinated muscle activities of upper body

COMPARISON OF PROPRIOCEPTION PERCEPTION TEST BETWEEN GOLFER AND NON-GOLFER USING TILTING PLATFORM

The purpose of this study was to test proprioception perception and compare between collegiate golfers and non-golfers using tilting platform. Sixteen male and fourteen female golfers and fifteen male and thirteen non-golfers were participated. All participants were performed perception test on the tilting platform. Frequency analysis and independent t-test were performed using SPSS 24.0. Alpha set at .05. Most participants were perceived from 1° to 2° of slopes and perceived left-right (target direction) slope than forward-backward slope. Repeated practice such as walking on the uneven ground or standing on sloped ground might help to improve proprioception perception. Further research using a tilting platform will be to develop the training program

EFFECTS OF GENDER AND FOOT POSITION ON ACCELERATION PATTERN OF KNEE AND HIP JOINT DURING DEEP SQUAT

The purpose of this study was to investigate the effect of gender and foot position on the acceleration patterns of the knee and hip joints during deep squat. Twenty-two male and 10 female collegiate students participated in this study. All the participants performed a deep squat two times in neutral foot position (NFP), with the foot rotated externally by 15° (ERFP). A wireless triaxial accelerometer was attached on the right-side knee and hip joints of each participant. Acceleration data generated in the anterior-posterior (AP), medio-lateral (ML), and superior-inferior (SI) directions during deep squat were collected through the attached acceleration sensor (2000Hz). Statistical analysis was performed using SPSS 24.0, and mixed analysis of variance (p \u3c 0.05) was used to identify the interaction and main effects of gender and foot positions. The acceleration patterns of the knee joint during deep squat according to gender indicated differences between the AP and ML directions. The acceleration motion of the hip joint under the ERFP condition indicated a difference in the SI direction

Molecular Weight Dependent Glucose Lowering Effect of Low Molecular Weight Chitosan Oligosaccharide (GO2KA1) on Postprandial Blood Glucose Level in SD Rats Model

Abstract This research investigated the effect of enzymatically digested low molecular weight (MW) chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan oligosaccharide samples with varying MW were evaluated in vitro for inhibition of rat small intestinal α-glucosidase and porcine pancreatic α-amylase (GO2KA1; \u3c1000 Da, GO2KA2; 1000–10,000 Da, GO2KA3; MW \u3e 10,000 Da). The in vitro results showed that all tested samples had similar rat α-glucosidase inhibitory and porcine α-amylase inhibitory activity. Based on these observations, we decided to further investigate the effect of all three samples at a dose of 0.1 g/kg, on reducing postprandial blood glucose levels in Sprague-Dawley (SD) rat model after sucrose loading test. In the animal trial, all tested samples had postprandial blood glucose reduction effect, when compared to control, however GO2KA1 supplementation had the strongest effect. The glucose peak (Cmax) for GO2KA1 and control was 152 mg/dL and 193 mg/dL, respectively. The area under the blood glucose-time curve (AUC) for GO2KA1 and control was 262 h mg/dL and 305 h mg/dL, respectively. Furthermore, the time of peak plasma concentration of blood glucose (Tmax) for GO2KA1 was significantly delayed (0.9 h) compared to control (0.5 h). These results suggest that GO2KA1 could have a beneficial effect for blood glucose management relevant to diabetes prevention in normal and pre-diabetic individuals. The suggested mechanism of action is via inhibition of the carbohydrate hydrolysis enzyme α-glucosidase and since GO2KA1 (MW \u3c 1000 Da) had higher in vivo effect, we hypothesize that it is more readily absorbed and might exert further biological effect once it is absorbed in the blood stream, relevant to blood glucose management

Platelet-derived growth factor induces p21/WAF1 promoter in vascular smooth muscle cells via activation of an Sp1 site

AbstractMany studies suggested that cyclin-dependent kinase inhibitor (CDKI) p21 acts as a universal inhibitor of cyclin/CDK catalytic activity. This protein has also been shown to be a component of active cyclin/CDK complexes. In addition, it has recently been suggested that p21 serves as an assembly factor in platelet-derived growth factor (PDGF)-stimulated vascular smooth muscle cells (VSMC). However, little is known concerning the molecular mechanisms by which PDGF induces p21 gene expression in VSMC. In this report we demonstrate that PDGF induces the p21 expression at both the mRNA and protein levels. This increase in p21 gene expression was due to activation of the p21 promoter by PDGF. Through both deletion and mutation analysis of the p21 promoter, we defined a 10-bp sequence that is required for the activation of the p21 promoter by PDGF. In addition, gel shift and supershift assays demonstrated that this PDGF-responsive element binds specifically to the transcription factor Sp1. These results demonstrate that Sp1 mediates PDGF-induced p21 gene expression in VSMC. Moreover, immunoblot and immonoprecipitation analysis showed that the level of hyperphosphorylated retinoblastoma protein (Rb) is increased and the protein is physically associated with Sp1 in PDGF-treated cells, indicating that phosphorylated Rb may play a role in regulating Sp1 to activate p21 expression