Effects of increasing the degree of building height asymmetry on ventilation and pollutant dispersion within street canyons

Rational urban design helps to build sustainable cities with high ventilation capacity and pollutant removal capacity, but the effect of building height on ventilation and pollutant dispersion inside asymmetric canyons has not been fully studied. In this paper, we studied the effect of increasing the degree of building height asymmetry (DBHA) on canyon ventilation and pollutant diffusion in shallow and deep asymmetric street canyons by considering six different building height ratios (BHR = 3/4, 1/2, 1/3, 4/3, 2/1 and 3/1). The results show that increasing the DBHA in asymmetric canyons can improve the ventilation and pollutant removal capacity. For step-up canyons, increasing the downwind building height is very useful to improve ventilation and pollutant removal. For shallow/deep step-up canyons with BHR = 1/3, the air exchange rate (ACH) increased to 211.2% and 380.1% of the flat canyons, respectively. The spatially-average pollutant concentration in the pedestrian zones (leeward Kavg* ang windward Kavg*) decreases significantly with the increase of DBHA, especially for the deep step-up canyon with BHR = 1/3, the leeward Kavg* and windward Kavg* decrease to 15.3% and 3%, respectively. Also, increasing the upwind building height can also improve the ventilation capacity in the step-down canyons. For the deep step-down canyon with BHR = 3/1, the leeward Kavg* and windward Kavg* decreased to 40.6% and 24.1% of the deep flat canyon, respectively. Notably, the ventilation capacity is very low for step-down canyons with BHR = 4/3, and for step-down canyons with BHR ≥ 2/1, the ventilation capacity and pollutant removal capacity increase significantly with the increase of DBHA. Therefore, in urban planning, step-down canyons with BHR = 4/3 should be avoided and designed to satisfy the condition of BHR ≥ 2/1. These findings will be a valuable reference for urban designers to build sustainable cities with high ventilation capacity

Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry

International audienceIn this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected

Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Background: Previous studies suggested potential ethnic differences in the management and outcomes of atrial fibrillation (AF). We aim to analyse oral anticoagulant (OAC) prescription, discontinuation, and risk of adverse outcomes in Asian patients with AF, using data from a global prospective cohort study. Methods: From the GLORIA-AF Registry Phase II-III (November 2011-December 2014 for Phase II, and January 2014-December 2016 for Phase III), we analysed patients according to their self-reported ethnicity (Asian vs. non-Asian), as well as according to Asian subgroups (Chinese, Japanese, Korean and other Asian). Logistic regression was used to analyse OAC prescription, while the risk of OAC discontinuation and adverse outcomes were analysed through Cox-regression model. Our primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACE). The original studies were registered with ClinicalTrials.gov, NCT01468701, NCT01671007, and NCT01937377. Findings: 34,421 patients were included (70.0 ± 10.5 years, 45.1% females, 6900 (20.0%) Asian: 3829 (55.5%) Chinese, 814 (11.8%) Japanese, 1964 (28.5%) Korean and 293 (4.2%) other Asian). Most of the Asian patients were recruited in Asia (n = 6701, 97.1%), while non-Asian patients were mainly recruited in Europe (n = 15,449, 56.1%) and North America (n = 8378, 30.4%). Compared to non-Asian individuals, prescription of OAC and non-vitamin K antagonist oral anticoagulant (NOAC) was lower in Asian patients (Odds Ratio [OR] and 95% Confidence Intervals (CI): 0.23 [0.22-0.25] and 0.66 [0.61-0.71], respectively), but higher in the Japanese subgroup. Asian ethnicity was also associated with higher risk of OAC discontinuation (Hazard Ratio [HR] and [95% CI]: 1.79 [1.67-1.92]), and lower risk of the primary composite outcome (HR [95% CI]: 0.86 [0.76-0.96]). Among the exploratory secondary outcomes, Asian ethnicity was associated with higher risks of thromboembolism and intracranial haemorrhage, and lower risk of major bleeding. Interpretation: Our results showed that Asian patients with AF showed suboptimal thromboembolic risk management and a specific risk profile of adverse outcomes; these differences may also reflect differences in country-specific factors. Ensuring integrated and appropriate treatment of these patients is crucial to improve their prognosis. Funding: The GLORIA-AF Registry was funded by Boehringer Ingelheim GmbH

Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF

BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes