Trust \u3ci\u3eThe Key to Leading When Lives Are on the Line\u3c/i\u3e

The Hostage Rescue Team (HRT) of the Federal Bureau of Investigation was called in to assist the bureau\u27s Special Weapons and Tactics (SWAT) team in Memphis to apprehend a married couple wanted on drug trafficking charges. The fugitive couple and an adult son, all with criminal records, were believed to be living in trailers in a mountain valley where outsiders would be easily noticed. The fugitives were known to stockpile weapons and had vowed never to be taken alive by law enforcement. Thus the FBI considered them to be armed and extremely dangerous. Two HRT snipers along with two SWAT snipers were given the mission of positively identifying the fugitives and providing security and containment for the assault force. The snipers would have to travel several kilometers through wooded, mountainous terrain using night vision goggles (NVGs). The SWAT snipers did not have nighttime, overland movement capability, which is why HRT was brought in

Effect of substrate thermal resistance on space-domain microchannel

In recent years, Fluorescent Melting Curve Analysis (FMCA) has become an almost ubiquitous feature of commercial quantitative PCR (qPCR) thermal cyclers. Here a micro-fluidic device is presented capable of performing FMCA within a microchannel. The device consists of modular thermally conductive blocks which can sandwich a microfluidic substrate. Opposing ends of the blocks are held at differing temperatures and a linear thermal gradient is generated along the microfluidic channel. Fluorescent measurements taken from a sample as it passes along the micro-fluidic channel permits fluorescent melting curves to be generated. In this study we measure DNA melting temperature from two plasmid fragments. The effects of flow velocity and ramp-rate are investigated, and measured melting curves are compared to those acquired from a commercially available PCR thermocycler

MESSENGER observations of dipolarization events in Mercury's magnetotail

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95196/1/jgra22066.pd

MESSENGER Observations of Dipolarization Events in Mercury's Magnetotail

Several series of large dipolarization events are documented from magnetic field observations in Mercury's magnetotail made by the MESSENGER spacecraft. The dipolarizations are identified by a rapid (∼1 s) increase in the northward component of the magnetic field, followed by a slower return (∼10 s) to pre-onset values. The changes in field strength during an event frequently reach 40 nT or higher, equivalent to an increase in the total magnetic field magnitude by a factor of ∼4 or more. The presence of spatially constrained dipolarizations at Mercury provides a key to understanding the magnetic substorm process in a new parameter regime: the dipolarization timescale, which is shorter than at Earth, is suspected to lead to efficient non-adiabatic heating of the plasma sheet proton population, and the high recurrence rate of the structures is similar to that frequently observed for flux ropes and traveling compression regions in Mercury's magnetotail. The relatively short lifetime of the events is attributed to the lack of steady field-aligned current systems at Mercury

The Combinatorics of Alternating Tangles: from theory to computerized enumeration

We study the enumeration of alternating links and tangles, considered up to topological (flype) equivalences. A weight $n$ is given to each connected component, and in particular the limit $n\to 0$ yields information about (alternating) knots. Using a finite renormalization scheme for an associated matrix model, we first reduce the task to that of enumerating planar tetravalent diagrams with two types of vertices (self-intersections and tangencies), where now the subtle issue of topological equivalences has been eliminated. The number of such diagrams with $p$ vertices scales as $12^p$ for $p\to\infty$. We next show how to efficiently enumerate these diagrams (in time $\sim 2.7^p$) by using a transfer matrix method. We give results for various generating functions up to 22 crossings. We then comment on their large-order asymptotic behavior.Comment: proceedings European Summer School St-Petersburg 200

A new method to explore the spectral impact of the piriform fossae on the singing voice : Benchmarking using MRI-based 3D-printed vocal tracts

The piriform fossae are the 2 pear-shaped cavities lateral to the laryngeal vestibule at the lower end of the vocal tract. They act acoustically as side-branches to the main tract, resulting in a spectral zero in the output of the human voice. This study investigates their spectral role by comparing numerical and experimental results of MRI-based 3D printed Vocal Tracts, for which a new experimental method (based on room acoustics) is introduced. The findings support results in the literature: the piriform fossae create a spectral trough in the region 4–5 kHz and act as formants repellents. Moreover, this study extends those results by demonstrating numerically and perceptually the impact of having large piriform fossae on the sung output

Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses.

The Mouse Phenome Database continues to serve as a curated repository and analysis suite for measured attributes of members of diverse mouse populations. The repository includes annotation to community standard ontologies and guidelines, a database of allelic states for 657 mouse strains, a collection of protocols, and analysis tools for flexible, interactive, user directed analyses that increasingly integrates data across traits and populations. The database has grown from its initial focus on a standard set of inbred strains to include heterogeneous mouse populations such as the Diversity Outbred and mapping crosses and well as Collaborative Cross, Hybrid Mouse Diversity Panel, and recombinant inbred strains. Most recently the system has expanded to include data from the International Mouse Phenotyping Consortium. Collectively these data are accessible by API and provided with an interactive tool suite that enables users\u27 persistent selection, storage, and operation on collections of measures. The tool suite allows basic analyses, advanced functions with dynamic visualization including multi-population meta-analysis, multivariate outlier detection, trait pattern matching, correlation analyses and other functions. The data resources and analysis suite provide users a flexible environment in which to explore the basis of phenotypic variation in health and disease across the lifespan

Uphold the nuclear weapons test moratorium

The Trump administration is considering renewing nuclear weapons testing (1), a move that could increase the risk of another nuclear arms race as well as an inadvertent or intentional nuclear war. Following in the long tradition of scientists opposing nuclear weapons due to their harmful effects on both humanity and the planet (2), we ask the U.S. government to desist from plans to conduct nuclear tests. During the Cold War, the United States conducted 1030 nuclear weapons tests, more than all other nuclear-armed nations combined (3). In 1996, the United States signed the Comprehensive Nuclear Test Ban Treaty (CTBT), agreeing not to conduct a nuclear weapons test of any yield (4). The United States has not yet ratified the CTBT but did spearhead the 2016 adoption of UN Security Council Resolution 2310, which calls upon all countries to uphold the object and purpose of the CTBT by not conducting nuclear tests (5). Eight of the nine nuclear-armed states, including the five permanent members of the UN Security Council, have observed a moratorium on nuclear testing since 1998 (3, 4). The ninth, North Korea, responding to international pressure, stopped testing warhead detonations (as opposed to missile flights) in 2017 (6). If the United States ratified the CTBT, joining the 168 countries who have already done so (4), there is a good chance that the other holdout countries would ratify the treaty as well (7)

Uphold the nuclear weapons test moratorium

The Trump administration is considering renewing nuclear weapons testing (1), a move that could increase the risk of another nuclear arms race as well as an inadvertent or intentional nuclear war. Following in the long tradition of scientists opposing nuclear weapons due to their harmful effects on both humanity and the planet (2), we ask the U.S. government to desist from plans to conduct nuclear tests. During the Cold War, the United States conducted 1030 nuclear weapons tests, more than all other nuclear-armed nations combined (3). In 1996, the United States signed the Comprehensive Nuclear Test Ban Treaty (CTBT), agreeing not to conduct a nuclear weapons test of any yield (4). The United States has not yet ratified the CTBT but did spearhead the 2016 adoption of UN Security Council Resolution 2310, which calls upon all countries to uphold the object and purpose of the CTBT by not conducting nuclear tests (5). Eight of the nine nuclear-armed states, including the five permanent members of the UN Security Council, have observed a moratorium on nuclear testing since 1998 (3, 4). The ninth, North Korea, responding to international pressure, stopped testing warhead detonations (as opposed to missile flights) in 2017 (6). If the United States ratified the CTBT, joining the 168 countries who have already done so (4), there is a good chance that the other holdout countries would ratify the treaty as well (7)