Relationship Between Heat and Troughs During a Transport Process of Heating the Pet Films

Understanding the troughs caused during a heat treatment process is important for ensuring process stability and product quality in roll-to-roll (R2R) productions methodology. The purpose of this study is to confirm the relationship between heat and troughs during a transport process of heating where heat is applied over a wide range of area. The temperature and tension applied to the web during the heated transport process were measured in the experimental analysis. Results showed that the web were stretched in the web transport direction during the heat transfer process. However, troughs did not occur because the experiment was conducted below the glass transition temperature. The comparison between the web temperature obtained in the experimental analysis with the one-dimensional thermal conduction simulation for the temperature distribution of the web are also conducted in this paper. This simulation was performed using a non-Fourier model that can be used on microscales. Simulation results show that when the temperature is gradually raised, the amount of thermal conduction is reduced during transportation of the web. The thermal conduction of ballistic phonon is smaller than that of the diffuse phonon when compared at same distance. Even though there were differences between the experimental values and the simulation results, this is because it ignores the heat transfer and radiant heat transfer

Relationship Between Heat and Troughs During a Transport Process of Heating the Pet Films

Understanding the troughs caused during a heat treatment process is important for ensuring process stability and product quality in roll-to-roll (R2R) productions methodology. The purpose of this study is to confirm the relationship between heat and troughs during a transport process of heating where heat is applied over a wide range of area. The temperature and tension applied to the web during the heated transport process were measured in the experimental analysis. Results showed that the web were stretched in the web transport direction during the heat transfer process. However, troughs did not occur because the experiment was conducted below the glass transition temperature. The comparison between the web temperature obtained in the experimental analysis with the one-dimensional thermal conduction simulation for the temperature distribution of the web are also conducted in this paper. This simulation was performed using a non-Fourier model that can be used on microscales. Simulation results show that when the temperature is gradually raised, the amount of thermal conduction is reduced during transportation of the web. The thermal conduction of ballistic phonon is smaller than that of the diffuse phonon when compared at same distance. Even though there were differences between the experimental values and the simulation results, this is because it ignores the heat transfer and radiant heat transfer

On the func­tion of the Megakaryocyte (Motility, Separation of the Platelet and Phagocytosis), Observations Both in Idiopathic Thrombo-cytopenic Purpura and in Normal Adult

The idiopathic thrombocytopenic purpura was described by Werlhof as an independent disease first in 1738. Kaznelson reported the excellent effect of splenectomy for its chronic type in 1915. For the genesis of its thrombocytopenia, there have been many theories to be concluded into the followings, 1) the development of an auto-immune mechanism resulting in platelet destruction, 2) increased platelet destruction in the spleen, 3) the inhibition of platelet production from the marrow megakaryocytes by a humoral factor produced in the spleen, 4) both increased destruction and decreased production of the platelet. Among the above four theories, the third one is the most popular in the chronic type.</p

Relationship Between Heat and Troughs During a Transport Process of Heating the Pet Films

Understanding the troughs caused during a heat treatment process is important for ensuring process stability and product quality in roll-to-roll (R2R) productions methodology. The purpose of this study is to confirm the relationship between heat and troughs during a transport process of heating where heat is applied over a wide range of area. The temperature and tension applied to the web during the heated transport process were measured in the experimental analysis. Results showed that the web were stretched in the web transport direction during the heat transfer process. However, troughs did not occur because the experiment was conducted below the glass transition temperature. The comparison between the web temperature obtained in the experimental analysis with the one-dimensional thermal conduction simulation for the temperature distribution of the web are also conducted in this paper. This simulation was performed using a non-Fourier model that can be used on microscales. Simulation results show that when the temperature is gradually raised, the amount of thermal conduction is reduced during transportation of the web. The thermal conduction of ballistic phonon is smaller than that of the diffuse phonon when compared at same distance. Even though there were differences between the experimental values and the simulation results, this is because it ignores the heat transfer and radiant heat transfer

Modelling state-dependent interference in common cranes

1. Interference is a key component of food competition, but is difficult to measure in natural animal populations. Using data from a long-term study, we show that interference between common cranes Grus grus L., feeding on patches of cereal seeds, reduces intake rates at high competitor densities, and that the strength of interference is unrelated to food abundance. 2. An alternative to measuring interference directly is to predict its strength using behaviour-based models. We test an interference model, originally developed for shorebirds feeding on invertebrate prey, for cranes. We compare the predictions of a rate-maximizing model, in which animals steal food if this increases intake rate, and a state-dependent model, in which they only rate-maximize if their intake rate is below a target value, otherwise they minimize injury risk by not stealing food. State-dependent aggression occurs in cranes. 3. The state-dependent model predicts more accurately the relative aggression rates of cranes of different dominance. However, both models predict accurately the observed strength of interference, that the strength of interference is unrelated to food abundance, at least within the observed range of crane and seed densities, and that cranes of a higher dominance have a higher intake rate than those of lower dominance. 4. This paper shows how state-dependent behaviour can be incorporated into an interference model, and that the model can produce accurate predictions for a system quite different to that for which it was developed.RAS was funded by the Natural Environment Research Council. LMB was partially funded by Ministerio de Ciencia y Tecnología (MCyT) and research grant PB97-1252 of MCyT. Field work was funded by DGICYT project PB87-0389 of the MCyT.Peer reviewe

Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX is a key enzyme in prostaglandin biosynthesis, and two isoforms of COX, COX-1 and COX-2, have been identified. Recently COX-2 has been reported to frequently overexpress in colorectal neoplasms and to play a role in colorectal tumorigenesis and tumour progression. In this study, using immunohistochemistry, we examined COX-2 expression in advanced human colorectal cancer and its correlation with clinicopathological features. COX-2 expression was observed mainly in the cytoplasm of cancer cells in all the specimens examined, but some stromal cells and endothelial cells were also stained. According to the grade of COX-2 expression of the cancer cells, patients were divided into high- and low-COX-2 expression groups. High-COX-2 expression significantly correlated with tumour recurrence, especially haematogenous metastasis. These results suggest that a selective COX-2 inhibitor can be a novel class of therapeutic agents not only for tumorigenesis but also for haematogenous metastasis of cololectal cancer. To our knowledge, this is the first report on the correlation between COX-2 overexpression and recurrence of colorectal cancer. © 2000 Cancer Research Campaig

Cell-Sized confinement in microspheres accelerates the reaction of gene expression

Cell-sized water-in-oil droplet covered by a lipid layer was used to understand how lipid membranes affect biochemical systems in living cells. Here, we report a remarkable acceleration of gene expression in a cell-sized water-in-oil droplet entrapping a cell-free translation system to synthesize GFP (green fluorescent protein). The production rate of GFP (VGFP) in each droplet remained almost constant at least for on the order of a day, which implies 0th-order reaction kinetics. Interestingly, VGFP was inversely proportional to radius of droplets (R) when R is under 50 μm, and VGFP in droplets with R ∼ 10 μm was more than 10 times higher than that in the bulk. The acceleration rates of GFP production in cell-sized droplets strongly depended on the lipid types. These results demonstrate that the membrane surface has the significant effect to facilitate protein production, especially when the scale of confinement is on the order of cell-size

Antigen-expressing immunostimulatory liposomes as a genetically programmable synthetic vaccine

Liposomes are versatile (sub)micron-sized membrane vesicles that can be used for a variety of applications, including drug delivery and in vivo imaging but they also represent excellent models for artificial membranes or cells. Several studies have demonstrated that in vitro transcription and translation can take place inside liposomes to obtain compartmentalized production of functional proteins within the liposomes (Kita et al. in Chembiochem 9(15):2403–2410, 2008; Moritani et al.in FEBS J, 2010; Kuruma et al. in Methods Mol Biol 607:161–171, 2010; Murtas et al. in Biochem Biophys Res Commun 363(1):12–17, 2007; Sunami et al. in Anal Biochem 357(1):128–136, 2006; Ishikawa et al. in FEBS Lett 576(3):387–390, 2004; Oberholzer et al. in Biochem Biophys Res Commun 261(2):238–241, 1999). Such a minimal artificial cell-based model is ideal for synthetic biology based applications. In this study, we propose the use of liposomes as artificial microbes for vaccination. These artificial microbes can be genetically programmed to produce specific antigens at will. To show proof-of-concept for this artificial cell-based platform, a bacterial in vitro transcription and translation system together with a gene construct encoding the model antigen β-galactosidase were entrapped inside multilamellar liposomes. Vaccination studies in mice showed that such antigen-expressing immunostimulatory liposomes (AnExILs) elicited higher specific humoral immune responses against the produced antigen (β-galactosidase) than control vaccines (i.e. AnExILs without genetic input, liposomal β-galactosidase or pDNA encoding β-galactosidase). In conclusion, AnExILs present a new platform for DNA-based vaccines which combines antigen production, adjuvanticity and delivery in one system and which offer several advantages over existing vaccine formulations