Characteristics and outcomes of fetal ventricular aneurysm and diverticulum: combining the use of a new technique, fetal HQ

ObjectivesCongenital ventricular aneurysms or diverticulum (VA/VD) are rare cardiac anomalies with lack prenatal evaluation data. The present study aimed to provide the prenatal characteristics and outcomes from a tertiary center and the use of new techniques to evaluate the shape and contractility of these fetuses.MethodsTen fetuses were diagnosed with VA or VD, and 30 control fetuses were enrolled. Fetal echocardiography was performed to make the diagnosis. The prenatal echo characteristics and follow-up data were carefully reviewed. The shape and contractility measurements of the four-chamber view (4CV) and both ventricles were measured and computed using fetal fetal heart quantification (HQ).ResultsA total of 10 fetuses were enrolled, including 4 cases of left ventricular diverticulum, 5 cases of left ventricular aneurysm, and 1 case of right ventricular aneurysm (RVA). Four cases chose to terminate the pregnancy. The RVA was associated with a perimembranous ventricular septal defect. Two cases had fetal arrhythmia, and one case had pericardial effusion. After birth, one case underwent surgical resection at five years old. The 4CV global sphericity index (SI) of free-wall located ventricular outpouching (VO) was significantly lower than the apical ones and the control group (p < 0.01). Four of five apical left VOs had significant higher (>95th centile) SI in base segments, and three of four left VOs in the free-wall had significant lower (< 5th centile) SI in the majority of 24 segments. Compared to the control group, the left ventricle (LV) global longitudinal strain, ejection fraction, and fractional area change were significantly decreased (p < 0.01), while the LV cardiac output of the cases was in the normal range. The transverse fraction shortening of the affected segments of ventricles was significantly lower than the other ventricle segments (p < 0.01).ConclusionsFetal HQ is a promising technique to evaluate the shape and contractility of congenital ventricular aneurysm and diverticulum

Construction and validation of a musculoskeletal disease risk prediction model for underground coal miners

ObjectiveTo understand the prevalence among underground coal miners of musculoskeletal disorders (MSDs), analyze the risk factors affecting MSDs, and develop and validate a risk prediction model for the development of MSDs.Materials and methodsMSD questionnaires were used to investigate the prevalence of work-related musculoskeletal disorders among 860 underground coal miners in Xinjiang. The Chinese versions of the Effort-Reward Imbalance Questionnaire (ERI), the Burnout Scale (MBI), and the Self-Rating Depression Inventory (SDS) were used to investigate the occupational mental health status of underground coal miners. The R4.1.3 software cart installation package was applied to randomly divide the study subjects into a 1:1 training set and validation set, screen independent predictors using single- and multi-factor regression analysis, and draw personalized nomogram graph prediction models based on regression coefficients. Subject work characteristic (ROC) curves, calibration (Calibrate) curves, and decision curves (DCA) were used to analyze the predictive value of each variable on MSDs and the net benefit.Results(1) The prevalence of MSDs was 55.3%, 51.2%, and 41.9% since joining the workforce, in the past year, and in the past week, respectively; the highest prevalence was in the lower back (45.8% vs. 38.8% vs. 33.7%) and the lowest prevalence was in the hips and buttocks (13.3% vs. 11.4% vs. 9.1%) under different periods. (2) Underground coal miners: the mean total scores of occupational stress, burnout, and depression were 1.55 ± 0.64, 51.52 ± 11.53, and 13.83 ± 14.27, respectively. (3) Univariate regression revealed a higher prevalence of MSDs in those older than 45 years (49.5%), length of service > 15 years (56.4%), annual income <$60,000 (79.1$60,000 (OR = 1.742, 95% CI: 1.100–2.759), and severe burnout (OR = 0.284, 95% CI: 0.109–0.739), and that these were independent predictors of the occurrence of MSDs among workers in underground coal mine operations (p <  0.05). (5) The areas under the ROC curve for the training and validation sets were 0.665 (95% CI: 0.615–0.716) and 0.630 (95% CI: 0.578–0.682), respectively, indicating that the model has good predictive ability; the calibration plots showed good agreement between the predicted and actual prevalence of the model; and the DCA curves suggested that the predictive value of this nomogram model for MSDs was good.ConclusionThe prevalence of MSDs among workers working underground in coal mines was high, and the constructed nomogram showed good discriminatory ability and optimal accuracy

Rare Copy Number Variants Identify Novel Genes in Sporadic Total Anomalous Pulmonary Vein Connection

Total anomalous pulmonary venous connection (TAPVC) is a rare congenital heart anomaly. Several genes have been associated TAPVC but the mechanisms remain elusive. To search novel CNVs and candidate genes, we screened a cohort of 78 TAPVC cases and 100 healthy controls for rare copy number variants (CNVs) using whole exome sequencing (WES). Then we identified pathogenic CNVs by statistical comparisons between case and control groups. After that, we identified altogether eight pathogenic CNVs of seven candidate genes (PCSK7, RRP7A, SERHL, TARP, TTN, SERHL2, and NBPF3). All these seven genes have not been described previously to be related to TAPVC. After network analysis of these candidate genes and 27 known pathogenic genes derived from the literature and publicly database, PCSK7 and TTN were the most important genes for TAPVC than other genes. Our study provides novel candidate genes potentially related to this rare congenital birth defect (CHD) which should be further fundamentally researched and discloses the possible molecular pathogenesis of TAPVC

Second-Order Model-Based Predictive Control of Dual Three-Phase PMSM Based on Current Loop Operation Optimization

To reduce the amount of computation in traditional model predictive current control, to improve the flexibility in choosing the direction and amplitude in the voltage vector synthesis of a dual three-phase motor by two degrees of freedom, and to reduce the output torque ripple and current ripple, this paper proposes a dual second-order model predictive control algorithm based on current loop operation optimization. Compared with the conventional speed loop using the PI control algorithm and the traditional MPC control algorithm, the proposed algorithm adopts the second-order MPC control mode in the speed loop, which decreases the speed regulation time and increases motor immunity. Meanwhile, the second-order MPC control mode is adopted in the current loop, and the traditional iterative calculation method is improved to calculate the direction and amplitude of the output voltage vector through the analytic function, which increases the flexibility of the output voltage vector. Additionally, a four-vector SVPWM is employed to modulate the voltage vector to reduce the current amplitude in the harmonic subspace. The simulation results indicate that the algorithm proposed in this paper can significantly reduce the torque ripple and the current ripple as well as increase the transient performance of the motor

Multiobjective Optimization of Cable Forces and Counterweights for Universal Cable-Stayed Bridges

In cable-stayed bridges, especially asymmetric bridges, counterweights are always made to work together with cable pretension forces to get a reasonable finished state. To solve the optimization problem of the cable-stayed bridge considering the counterweights, the integrated optimization method (IOM) for estimating cable forces and counterweights is proposed. In this method, the counterweights are proposed to act on the anchor points. After that, the summary of the minimum weighted total bending energy and the summary of the counterweights are considered as two objective functions of a multiobjective problem. Finally, the dynamic weighted coefficient method is used to solve this problem and realize the Pareto solution set. IOM presents detailed procedures in a simple numerical model and is then applied to the Yong-ding special-shaped cable-stayed bridge. The results show that not only IOM can realize the priority selection of the loading position of the counterweights but also get a better reasonable finish state because of the introduction of the counterweight dimension; the dynamic weighted coefficient method can quickly find the Pareto optimal solution set and be further screened by decision-makers; counterweight is very helpful to reduce torsion and other spatial effects in cable-stayed bridges. IOM can be used as a universal optimization method for cable-stayed bridges

A Cross-Sectional Epidemiological Survey of Work-Related Musculoskeletal Disorders and Analysis of Its Influencing Factors among Coal Mine Workers in Xinjiang

This study is to investigate the prevalence of work-related musculoskeletal disorders (MSDs) and the influencing factors among coal mine workers employed in on-site operations. The job burnout scale and MSD scale were implemented to investigate a random sample of 1,500 coal mine workers working in on-site operations in Xinjiang, China. In total, 1,325 valid questionnaires were collected, with a recovery rate of 88.33% (1,325/1,500). The rate of job burnout was 90%, of which 39.8% were categorized as mild burnout, 43.8% as moderate burnout, and 6.4% as severe burnout; the average job burnout score was 50.77±11.93. The annual prevalence of MSDs was 65.6%, with the highest annual prevalence in the waist (50.7%), followed by the neck, shoulder, and knee, and the lowest prevalence in the elbow (18.8%). Of the areas of the body affected by work-related MSDs, the highest proportion of requests for leave of absence was related to the waist, accounting for 25.7% of requests, while the lowest proportion (13.4%) was related to the wrist. In addition, the incidence of MSDs increased with the years of service. The lowest incidence of MSDs was associated with the two-shift and three-group working pattern. The prevalence of MSDs in the neck and waist was higher in women than in men. The prevalence of MSDs in various body parts increased with the years of service. Moreover, multiple logistic regression indicated that three shifts with four groups (OR=1.096, 95% CI: 0.832-1.445), working more than 10 years (OR=3.396, 95% CI: 2.369-5.748), working more than 20 years (OR=3.008, 95% CI: 1.419-6.337), significant bending (OR=2.062, 95% CI: 1.400-3.038), forward neck tilting (OR=1.572, 95% CI: 1.071-2.281), maximum force operation within a short period of time (OR=1.7222, 95% CI: 1.164-2.547), repeated movement of upper arms or fingers (OR=1.495, 95% CI: 1.034-2.161), slip or fall incidents (OR=1.124, 95% CI: 1.039-1.216), work under conditions of cold or temperature variations (OR=1.911, 95% CI: 1.342-2.720), mild burnout (OR=1.492, 95% CI: 1.016-2.191), moderate burnout (OR=1.852, 95% CI: 1.267-2.708), and severe burnout (OR=2.001, 95% CI: 1.145-3.496) were risk factors for MSDs. In conclusion, there is a high annual prevalence of MSDs among the coal mine workers employed in on-site operations in Xinjiang, China. Measures to reduce this prevalence are required

Prognosis and outcome of intrauterine treatment of fetuses with critical congenital heart disease

Abstract. Background:. Intrauterine valvuloplasty is an innovative therapy, which promotes ventricular growth and function in some congenital heart diseases (CHDs). The technique remains challenging and can only be performed in a few centers. This study aimed to assess the feasibility and mid-term outcomes of fetal cardiac intervention (FCI) in fetuses with critical CHD in an experienced tertiary center. Methods:. Five fetal aortic valvuloplasty (FAV) or fetal pulmonary valvuloplasty (FPV) procedures were performed in our fetal heart center between August 2018 and May 2022. Technical success was defined as crossing the aortic or pulmonary valve and balloon inflation, followed by evidence of increased blood flow across the valve and/or new regurgitation. Follow-up clinical records and echocardiography were obtained during the prenatal and postnatal periods. Results:. Five fetuses received FAV or FPV, including critical aortic stenosis ( n = 2) and pulmonary atresia with intact ventricular septum ( n = 3). The mean maternal age was 33.0 ± 2.6 years. The median gestational age (GA) at diagnosis was 24 weeks (range, 22–26 weeks). The median GA at intervention was 29 weeks (range, 28–32 weeks). All five cases underwent successful or partially successful procedures. One patient had pulmonary valve perforation without balloon dilation. No procedure-related deaths or significant complications occurred. However, one neonatal death occurred due to heart and renal failure. The median follow-up period was 29.5 months (range, 8.0–48.0 months). The four surviving patients had achieved biventricular circulation, exhibited improved valve, and ventricular development at the last follow-up visit. Conclusion:. Intrauterine FCI could be performed safely with good prognosis in critical CHD

Hydrophobization of fully bio-based epoxy polymers using water as solvent : effect of additives

Current epoxy industry still has a strong dependency on fossil-derived precursors as demonstrated in the use of bisphenol A-based resins. To improve the sustainability of the epoxy industry, bio-based chemicals have been explored for the synthesis of environmentally-friendly epoxy polymers. This paper reports the hydrophobization of fully bio-based epoxy coatings using only water as solvent. Three bio-based additives (hexanoic acid, resveratrol, and a cardanol-based epoxy resin) were studied aiming to enhance the hydrophobicity of the coatings. The curing reaction mechanisms have been extensively explored. The modified coatings showed better hydrophobicity, however, they tend to possess a lower crosslink density because these additives have, to some extent, disrupted the polymer network formation. The anticorrosion performance of the bio-based coatings was also evaluated and discussed based on the reported hydrophobicity and crosslink density. This study lays a foundation towards fully bio-based, environmentally-friendly polymers for hydrophobic applications in the future.Agency for Science, Technology and Research (A*STAR)We would like to express our gratitude to the Agency for Science, Technology and Research (A*STAR) of Singapore for the funds (SERC 1528000048) provided in this research

High-Throughput Isolation of Circulating Tumor Cells Using Cascaded Inertial Focusing Microfluidic Channel

Circulating tumor cells (CTCs) are rare cells that detach from a primary or metastasis tumor and flow into the bloodstream. Intact and viable tumor cells are needed for genetic characterization of CTCs, new drug development, and other research. Although separation of CTCs using spiral channel with two outlets has been reported, few literature demonstrated simultaneous isolation of different types of CTCs from human blood using cascaded inertial focusing microfluidic channel. Herein, we introduce a cascaded microfluidic device consisting of two spiral channels and one zigzag channel designed with different fluid fields, including lift force, Dean drag force, and centrifugal force. Both red blood cells (RBCs)-lysed human blood spiked with CTCs and 1:50 diluted human whole blood spiked with CTCs were tested on the presented chip. This chip successfully separated RBCs, white blood cells (WBCs), and two different types of tumor cells (human lung cancer cells (A549) and human breast cancer cells (MCF-7)) simultaneously based on their physical properties. A total of 80.75% of A549 and 73.75% of MCF-7 were faithfully separated from human whole blood. Furthermore, CTCs gathered from outlets could propagate and remained intact. The cell viability of A549 and MCF-7 were 95% and 98%, respectively. The entire separating process for CTCs from blood cells could be finished within 20 min. The cascaded microfluidic device introduced in this study serves as a novel platform for simultaneous isolation of multiple types of CTCs from patient blood