A quantum-inspired classical algorithm for separable Non-negative Matrix Factorization

Non-negative Matrix Factorization (NMF) asks to decompose a (entry-wise) non-negative matrix into the product of two smaller-sized nonnegative matrices, which has been shown intractable in general. In order to overcome this issue, separability assumption is introduced which assumes all data points are in a conical hull. This assumption makes NMF tractable and is widely used in text analysis and image processing, but still impractical for huge-scale datasets. In this paper, inspired by recent development on dequantizing techniques, we propose a new classical algorithm for separable NMF problem. Our new algorithm runs in polynomial time in the rank and logarithmic in the size of input matrices, which achieves an exponential speedup in the low-rank setting

Evaluation on the resistance to aphids of wheat germplasm resources in China

A collection of more than 200 wheat lines from the main wheat-producing areas of China was evaluated for resistance to wheat aphids, using fuzzy recognition technique in five field experiments over 2 years. The results show that susceptibility to wheat aphids was exhibited in most of the lines tested, and no immune and highly resistant lines to wheat aphids was observed. The average percentage of wheat germplasm lines with resistant, lowly susceptible, moderately susceptible and highly susceptible to aphid were 9.30, 23.15, 42.32, and 25.23%, respectively. 5 moderately resistant wheat germplasm lines to wheat aphids (Lantian18, Lantian20, Lantian22, Lantian00-30 and Shanmai175) were found in Jiangyou experimental station in 2009. More importantly, 2 wheat germplasm lines (Lantian20, Lantian22) with the continuous resistance to wheat aphid in the five experimental stations over 2 years were discovered. Although, resistance of wheat germplasm lines had a close relation to their genetics and inheritance, we also found that the resistance of the same wheat germplasm lines was varied in different experimental stations. It would be helpful to make wheat germplasm selections for breeding programs, especially if they have unique genes that may provide resistance to future biotypes of wheat aphids. A valuable method for evaluating the potential of aphid-resistance for wheat germplasm lines was also confirmed.Key words: Wheat germplasm lines, aphid, resistance identification

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

Interleukin-12 (IL-12) has been shown to possess potent immunoregulatory and antitumoral effects. We have evaluated the anti-oncogenic potential and the mechanisms of the antitumoral effect of in vivo adenovirus-mediated transfer of IL-12 gene in a murine model of colon cancer. AdCMVIL-12 was constructed to permit coordinated production of p40 and p35 subunits of IL-12 gene to obtain the maximum IL-12 bioactivity. Infection of murine colon cancer CT-26 cells in vitro with AdCMVIL-12 resulted in the production of high levels of IL-12. In vivo gene therapy of colon cancer nodules by intratumoral injection of AdCMVIL-12 induced a local increase in IL-12 and interferon-gamma levels and a complete regression of the tumor in 26 of 34 (76%) mice. Tumor disappeared between days 7 and 10 after vector administration. The antitumoral effect was mediated by CD8+ T cells and was associated with the generation of cytotoxic T lymphocytes against colon cancer cells. Animals that eliminated the tumor were protected against a second administration of neoplastic cells. Treatment with AdCMVIL-12 of one tumor nodule also caused regression of established tumors at distant sites. These data demonstrate that AdCMVIL-12 is a useful therapeutic tool for established colon cancer in mice and should be considered for application in humans

All-Inorganic Colloidal Perovskite Quantum Dots: A New Class of Lasing Materials with Favorable Characteristics

I), which were very recently reported as a high effi ciency luminescent materials. The CsPbX 3 IPQDs adopted here were fabricated following a recipe slightly modifi ed from the literature (see details in Experimental Section). Here, we present a new class of lasing materials with outstanding optical gain signatures of combined advantages of both QDs and halide perovskites: the colloidal all-inorganic cesium lead halide perovskite QDs (IPQDs) (CsPbX 3 , X = Cl, Br, Adv. Mater. 2015

Magnetic Resonance Imaging of Bone Marrow Cell-Mediated Interleukin-10 Gene Therapy of Atherosclerosis

A characteristic feature of atherosclerosis is its diffuse involvement of arteries across the entire human body. Bone marrow cells (BMC) can be simultaneously transferred with therapeutic genes and magnetic resonance (MR) contrast agents prior to their transplantation. Via systemic transplantation, these dual-transferred BMCs can circulate through the entire body and thus function as vehicles to carry genes/contrast agents to multiple atherosclerosis. This study was to evaluate the feasibility of using in vivo MR imaging (MRI) to monitor BMC-mediated interleukin-10 (IL-10) gene therapy of atherosclerosis.For in vitro confirmation, donor mouse BMCs were transduced by IL-10/lentivirus, and then labeled with a T2-MR contrast agent (Feridex). For in vivo validation, atherosclerotic apoE(-/-) mice were intravenously transplanted with IL-10/Feridex-BMCs (Group I, n = 5) and Feridex-BMCs (Group II, n = 5), compared to controls without BMC transplantation (Group III, n = 5). The cell migration to aortic atherosclerotic lesions was monitored in vivo using 3.0T MRI with subsequent histology correlation. To evaluate the therapeutic effect of BMC-mediated IL-10 gene therapy, we statistically compared the normalized wall indexes (NWI) of ascending aortas amongst different mouse groups with various treatments.Of in vitro experiments, simultaneous IL-10 transduction and Feridex labeling of BMCs were successfully achieved, with high cell viability and cell labeling efficiency, as well as IL-10 expression efficiency (≥90%). Of in vivo experiments, MRI of animal groups I and II showed signal voids within the aortic walls due to Feridex-created artifacts from the migrated BMCs in the atherosclerotic plaques, which were confirmed by histology. Histological quantification showed that the mean NWI of group I was significantly lower than those of group II and group III (P<0.05).This study has confirmed the possibility of using MRI to track, in vivo, IL-10/Feridex-BMCs recruited to atherosclerotic lesions, where IL-10 genes function to prevent the progression of atherosclerosis

A Policy-Driven Large Scale Ecological Restoration: Quantifying Ecosystem Services Changes in the Loess Plateau of China

As one of the key tools for regulating human-ecosystem relations, environmental conservation policies can promote ecological rehabilitation across a variety of spatiotemporal scales. However, quantifying the ecological effects of such policies at the regional level is difficult. A case study was conducted at the regional level in the ecologically vulnerable region of the Loess Plateau, China, through the use of several methods including the Universal Soil Loss Equation (USLE), hydrological modeling and multivariate analysis. An assessment of the changes over the period of 2000–2008 in four key ecosystem services was undertaken to determine the effects of the Chinese government's ecological rehabilitation initiatives implemented in 1999. These ecosystem services included water regulation, soil conservation, carbon sequestration and grain production. Significant conversions of farmland to woodland and grassland were found to have resulted in enhanced soil conservation and carbon sequestration, but decreased regional water yield under a warming and drying climate trend. The total grain production increased in spite of a significant decline in farmland acreage. These trends have been attributed to the strong socioeconomic incentives embedded in the ecological rehabilitation policy. Although some positive policy results have been achieved over the last decade, large uncertainty remains regarding long-term policy effects on the sustainability of ecological rehabilitation performance and ecosystem service enhancement. To reduce such uncertainty, this study calls for an adaptive management approach to regional ecological rehabilitation policy to be adopted, with a focus on the dynamic interactions between people and their environments in a changing world