English Literacy Development for English Language Learners: Does Spanish Instruction Promote or Hinder?

In this brief, the authors consider whether instruction in a child\u27s native language (particularly Spanish) hinders or promotes learning of literacy in English. The authors conduct a four-step process for identifying research on this topic, examining this literature, and then determining the answer to this clinical question. The results suggest that supporting a child\u27s home/native language promotes rather than hinders development of English literacy skills

Chandra and XMM-Newton Observations of NGC 4214: The Hot Interstellar Medium and the Luminosity Function of Dwarf Starbursts

We present results from Chandra and XMM-Newton X-ray observations of NGC 4214, a nearby dwarf starburst galaxy containing several young regions of very active star-formation. Starburst regions are known to be associated with diffuse X-ray emission, and in this case the X-ray emission from the galaxy shows an interesting morphological structure within the galaxy, clearly associated with the central regions of active star-formation. Of the two main regions of star-formation in this galaxy, X-ray emission associated with the older is identified whereas little is detected from the younger, providing an insight into the evolutionary process of the formation of superbubbles around young stellar clusters. The spectra of the diffuse emission from the galaxy can be fitted with a two temperature component thermal model with kT=0.14keV and 0.52keV, and analysis of this emission suggests that NGC 4214 will suffer a blow-out in the future. The point source population of the galaxy has an X-ray luminosity function with a slope of -0.76. This result, together with those for other dwarf starburst galaxies (NGC 4449 and NGC 5253), was added to a sample of luminosity functions for spiral and starburst galaxies. The slope of the luminosity function of dwarf starbursts is seen to be similar to that of their larger counterparts and clearly flatter than those seen in spirals. Further comparisons between the luminosity functions of starbursts and spiral galaxies are also made.Comment: 16 pages, 12 figures. Accepted for publication in MNRA

Remarks on Causality in Relativistic Quantum Field Theory

It is shown that the correlations predicted by relativistic quantum field theory in locally normal states between projections in local von Neumann algebras \cA(V_1),\cA(V_2) associated with spacelike separated spacetime regions $V_1,V_2$ have a (Reichenbachian) common cause located in the union of the backward light cones of $V_1$ and $V_2$. Further comments on causality and independence in quantum field theory are made.Comment: 10 pages, Latex, Quantum Structures 2002 Conference Proceedings submission. Minor revision of the order of definitions on p.

Reichenbach's Common Cause Principle in Algebraic Quantum Field Theory with Locally Finite Degrees of Freedom

In the paper it will be shown that Reichenbach's Weak Common Cause Principle is not valid in algebraic quantum field theory with locally finite degrees of freedom in general. Namely, for any pair of projections A and B supported in spacelike separated double cones O(a) and O(b), respectively, a correlating state can be given for which there is no nontrivial common cause (system) located in the union of the backward light cones of O(a) and O(b) and commuting with the both A and B. Since noncommuting common cause solutions are presented in these states the abandonment of commutativity can modulate this result: noncommutative Common Cause Principles might survive in these models

Stellar and Molecular Radii of a Mira Star: First Observations with the Keck Interferometer Grism

Using a new grism at the Keck Interferometer, we obtained spectrally dispersed (R ~ 230) interferometric measurements of the Mira star R Vir. These data show that the measured radius of the emission varies substantially from 2.0-2.4 microns. Simple models can reproduce these wavelength-dependent variations using extended molecular layers, which absorb stellar radiation and re-emit it at longer wavelengths. Because we observe spectral regions with and without substantial molecular opacity, we determine the stellar photospheric radius, uncontaminated by molecular emission. We infer that most of the molecular opacity arises at approximately twice the radius of the stellar photosphere.Comment: 12 pages, including 3 figures. Accepted by ApJ

Effect of variations in the doping profiles on the properties of doped multiple quantum well avalanche photodiodes

The purpose of this study is to use both theoretical and experimental evidence to determine the impact of doping imbalance and symmetry on the physical and electrical characteristics of doped multiple quantum well avalanche photodiodes (APD). Theoretical models have been developed to calculate the electric field valence and conduction bands, capacitance-voltage (CV), and carrier concentration versus depletion depth profiles. The models showed a strong correlation between the p- and n-doping balance inside the GaAs wells and the number of depleted stages and breakdown voltage of the APD. A periodic doping imbalance in the wells has been shown to result in a gradual increase (or decrease) in the electric field profile throughout the device which gave rise to partially depleted devices at low bias. The MQW APD structures that we modeled consisted of a 1 micron top p(+)-doped (3 x 10(exp 18) cm(exp -3)) GaAs layer followed by a 1 micron region of alternating layers of GaAs (500 A) and Al(0.42)Ga(0.58)As (500 A), and a 1 micron n(+) back layer (3 x 10(exp 18) cm(exp -3)). The GaAs wells were doped with p-i-n layers placed at the center of each well. The simulation results showed that in an APD with nine doped wells, and where the 50 A p-doped layer is off by 10% (p = 1.65 x 10(exp 18) cm(exp -3), n = 1.5 x 10(exp 18) cm(exp -3)), almost half of the MQW stages were shown to be undepleted at low bias which was a result of a reduction in the electric field near the p(+) cap layer by over 50% from its value in the balanced structure. Experimental CV and IV data on similar MBE grown MQW structures have shown very similar depletion and breakdown characteristics. The models have enabled us to better interpret our experimental data and to determine both the extent of the doping imbalances in the devices as well as the overall p- or n-type doping characteristics of the structures

PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation.

A new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1). Several drugs targeting PD-1 (pembrolizumab and nivolumab) or PD-L1 (atezolizumab, durvalumab, and avelumab) have been approved or are in the late stages of development. Inevitably, the introduction of these drugs will put pressure on healthcare systems, and there is a need to stratify patients to identify those who are most likely to benefit from such treatment. There is evidence that responsiveness to PD-1 inhibitors may be predicted by expression of PD-L1 on neoplastic cells. Hence, there is considerable interest in using PD-L1 immunohistochemical staining to guide the use of PD-1-targeted treatments in patients with NSCLC. This article reviews the current knowledge about PD-L1 testing, and identifies current research requirements. Key factors to consider include the source and timing of sample collection, pre-analytical steps (sample tracking, fixation, tissue processing, sectioning, and tissue prioritization), analytical decisions (choice of biomarker assay/kit and automated staining platform, with verification of standardized assays or validation of laboratory-devised techniques, internal and external quality assurance, and audit), and reporting and interpretation of the results. This review addresses the need for integration of PD-L1 immunohistochemistry with other tests as part of locally agreed pathways and protocols. There remain areas of uncertainty, and guidance should be updated regularly as new information becomes available

Ionization state, excited populations and emission of impurities in dynamic finite density plasmas: I. The generalized collisional-radiative model for light elements

The paper presents an integrated view of the population structure and its role in establishing the ionization state of light elements in dynamic, finite density, laboratory and astrophysical plasmas. There are four main issues, the generalized collisional-radiative picture for metastables in dynamic plasmas with Maxwellian free electrons and its particularizing to light elements, the methods of bundling and projection for manipulating the population equations, the systematic production/use of state selective fundamental collision data in the metastable resolved picture to all levels for collisonal-radiative modelling and the delivery of appropriate derived coefficients for experiment analysis. The ions of carbon, oxygen and neon are used in illustration. The practical implementation of the methods described here is part of the ADAS Project

Chandra & XMM-Newton Observations of NGC5253. Analysis of the X-ray Emission from a Dwarf Starburst Galaxy

We present Chandra and XMM-Newton X-ray data of NGC5253, a local starbursting dwarf elliptical galaxy, in the early stages of a starburst episode. Contributions to the X-ray emission come from discrete point sources and extended diffuse emission, in the form of what appear to be multiple superbubbles, and smaller bubbles probably associated with individual star clusters. Chandra detects 17 sources within the optical extent of NGC5253 down to a completeness level corresponding to a luminosity of 1.5E37 erg/s.The slope of the point source X-ray luminosity function is -0.54, similar to that of other nearby dwarf starburst galaxies. Several different types of source are detected within the galaxy, including X-ray binaries and the emission associated with star-clusters. Comparison of the diffuse X-ray emission with the observed Halpha emission shows similarities in their extent. The best spectral fit to the diffuse emission is obtained with an absorbed, two temperature model giving temperatures for the two gas components of ~0.24keV and ~0.75keV.The derived parameters of the diffuse X-ray emitting gas are as follows: a total mass of \~1.4E6 f^{1/2} Msun, where f is the volume filling factor of the X-ray emitting gas, and a total thermal energy content for the hot X-ray emitting gas of \~3.4E54 f^{1/2} erg. The pressure in the diffuse gas is P/k ~ 1E6f^{-1/2}K/cm3. We find that these values are broadly commensurate with the mass and energy injection from the starburst population. Analysis of the kinematics of the starburst region suggest that the stellar ejecta contained within it can escape the gravitational potential well of the galaxy, and pollute the surrounding IGM.Comment: 19 pages, In Press in MNRA