Comparison of lidocaine-lidocaine and lidocaine-esmolol efficiency in control of haemodynamic response to endotracheal extubation craniotomies

WOS: 000431893600014Purpose: In this study, we aimed to compare efficiency of lidocaine+lidocaine and lidocaine+esmolol combinations on elimination of undesirable hemodynamic changes during extubation. Materials and Methods: 60 patients ASA I-III scheduled for craniotomy were included in this study. Anaesthesia maintenance was provided with sevoflurane-remifentanil and 2 mg kg(-1) tramadol for postoperative pain. Lidocaine IV bolus 1 mg kg(-1) was administered to the patients 10 minutes before the end of operation in both groups. Lidocaine IV infusion 0.025 mg kg h(-1) and Esmolol IV infusion 50 mcg kg min(-1) was administered to Group I (Lidocain+Lidocain) and II (Lidocain+Esmolol) respectively. Haemodynamic parameters were recorded at 1, 5 and 10 minutes after lidokain and esmolol infusions. Results: There was a statistically significiant increase for haemodynamic changes after extubation when compared preoperative period in group I. There was a statistically significant increase for haemodynamic changes at 10 minutes after esmolol administration and extubation when compared preoperative period in group II. Extubation, eye opening, verbal response and orientation time in Group II were significantly longer than in Group I. Conclusion: Lidocaine bolus-lidocaine infusion which administered before extubation provided more stable hemodynamics and shorter extubation time than lidocaine bolus-esmolol infusion in patients who undergoing craniotomy