Bohemian Rhapository: Developing a music program archive in the IR

The Caine College of the Arts (CCA) Music Program Archives preserves artifacts of student, faculty, and guest artist musical contributions to scholarly and creative activity at Utah State University. This collection recognizes the value of campus musical history and community through collaboration between the Music Department, its liaison librarian, and the digital scholarship librarian. Founded in 2008, DigitalCommons@USU is the University\u27s institutional repository (IR). It is currently the 3rd largest Digital Commons instance in the nation, containing over 63,000 items. CCA and the Music Department are extremely underrepresented in the IR. This project - started March 2017 - is a first step in addressing this gap

No Really, We Can Help with This: Librarians Facilitating Research Assignment Design

Premises: Students need scaffolded, authentic opportunities to practice and develop research skills. Interdisciplinary faculty collaboration on assignment redesign facilitates peer feedback that isn\u27t usually available. Bringing librarians to the assignment design table establishes stronger connections with and among teaching faculty and promotes deeper learning opportunities for students. Key principles: Reflect on where students get stuck. Make the implicit explicit. Scaffold the research process. Offer formative assessment and opportunities for peer learning. Consider authentic, renewable, or public-facing end products

From Anecdotes to Data: Leveraging Our Assessment Toolkit to Determine How a New Curriculum Measures Up

This presentation shared the design and results of a mixed-methods assessment of a new library curriculum for ENGL 2010, the required English Composition course at Utah State University. Piloted with two sections of the course in fall semester 2019, this new three-session curriculum was grounded in case-based problem-based learning (CBPBL), a specific type of problem-based learning (PBL) in which students work together to solve real life scenarios and immediately apply their skills to a relevant and complex problem. Student teams used case studies to practice source evaluation, topic development, and synthesis of research in writing. Multiple assessment methods afforded us a rich understanding of our approach’s pedagogical efficacy, benefits, and challenges. We leveraged several approaches that have been used to evaluate library instruction in general and PBL in library instruction in particular. These were: a pre-/post-test student survey (e.g., Cook & Walsh 2012; Roberts 2017; Spackman & Camacho 2009); classroom observations (e.g., Carbery 2011); instructor reflections (e.g., Macklin 2001); and qualitative analysis of a sample of students’ weekly reflection papers (e.g., Cook & Walsh 2012; Diekema, Holliday, & Leary, 2011). Importantly, we also administered our pre-/post-test survey to two “control” sections of ENGL 2010 (not using the CBPBL curriculum), allowing for direct comparison of perceived and demonstrated student learning. These assessments helped us evaluate if a case-study-driven approach is indeed more engaging for students, and if practicing information literacy skills in the context of stories impacts student learning. Our research not only informs our practice teaching ENGL 2010 going forward but also offers a new contribution to the Scholarship of Teaching and Learning (SoTL) in information literacy

Immune Function and Muscle Adaptations to Resistance exercise in Older Adults: Study Protocol for a Randomized Controlled Trial of a Nutritional Supplement

BACKGROUND: Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will determine the relationship between immune function and exercise training outcomes for older adults who consume a nutritional supplement or placebo during resistance training and post-training follow-up. The supplement was chosen due to evidence suggesting its ingredients [arginine (Arg), glutamine (Gln), and β-hydroxy β-methylbutyrate (HMB)] can improve immune function, promote muscle growth, and counteract muscle loss. METHODS/DESIGN: Veterans (age 60 to 80 yrs, N = 50) of the United States military will participate in a randomized double-blind placebo-controlled trial of consumption of a nutritional supplement or placebo during completion of three study objectives: 1) determine if 2 weeks of supplementation improve immune function measured as the response to vaccination and systemic and cellular responses to acute resistance exercise; 2) determine if supplementation during 36 sessions of resistance training boosts gains in muscle size, strength, and function; and 3) determine if continued supplementation for 26 weeks post-training promotes retention of training-induced gains in muscle size, strength, and function. Analyses of the results for these objectives will determine the relationship between immune function and the training outcomes. Participants will undergo nine blood draws and five muscle (vastus lateralis) biopsies so that the effects of the supplement on immune function and the systemic and cellular responses to exercise can be measured. DISCUSSION: Exercise has known effects on immune function. However, the study will attempt to modulate immune function using a nutritional supplement and determine the effects on training outcomes. The study will also examine post-training benefit retention, an important issue for older adults, usually omitted from exercise studies. The study will potentially advance our understanding of the mechanisms of muscle gain and loss in older adults, but more importantly, a nutritional intervention will be evaluated as a complement to exercise for supporting muscle health during aging. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT02261961, registration date 10 June 2014, recruitment active

Wii-Fit for Improving Gait and Balance in an Assisted Living Facility: A Pilot Study

Objectives. To determine the effects on balance and gait of a Wii-Fit program compared to a walking program in subjects with mild Alzheimer's dementia (AD). Methods. A prospective randomized (1 : 1) pilot study with two intervention arms was conducted in an assisted living facility with twenty-two mild AD subjects. In both groups the intervention occurred under supervision for 30 minutes daily, five times a week for eight weeks. Repeated measures ANOVA and paired t-tests were used to analyze changes. Results. Both groups showed improvement in Berg Balance Scale (BBS), Tinetti Test (TT) and Timed Up and Go (TUG) over 8 weeks. However, there was no statistically significant difference between the groups over time. Intragroup analysis in the Wii-Fit group showed significant improvement on BBS (P = 0.003), and TT (P = 0.013). The walking group showed a trend towards improvement on BBS (P = 0.06) and TUG (P = 0.07) and significant improvement in TT (P = 0.06). Conclusion. This pilot study demonstrates the safety and efficacy of Wii-Fit in an assisted living facility in subjects with mild AD. Use of Wii-Fit resulted in significant improvements in balance and gait comparable to those in the robust monitored walking program. These results need to be confirmed in a larger, methodologically sound study

MicroRNA expression profile identifies high grade, non-muscle-invasive bladder tumors at elevated risk to progress to an invasive phenotype

Abstract: The objective of this study was to identify a panel of microRNAs (miRNAs) differentially expressed in high-grade non-muscle invasive (NMI; TaG3–T1G3) urothelial carcinoma that progress to muscle-invasive disease compared to those that remain non-muscle invasive, whether recurrence happens or not. Eighty-nine high-grade NMI urothelial carcinoma lesions were identified and total RNA was extracted from paraffin-embedded tissue. Patients were categorized as either having a non-muscle invasive lesion with no evidence of progression over a 3-year period or as having a similar lesion showing progression to muscle invasion over the same period. In addition, comparison of miRNA expression levels between patients with and without prior intravesical therapy was performed. Total RNA was pooled for microarray analysis in each group (non-progressors and progressors), and qRT-PCR of individual samples validated differential expression between non-progressive and progressive lesions. MiR-32-5p, -224-5p, and -412-3p were associated with cancer-specific survival. Downregulation of miR-203a-3p and miR-205-5p were significantly linked to progression in non-muscle invasive bladder tumors. These miRNAs include those implicated in epithelial mesenchymal transition, previously identified as members of a panel characterizing transition from the non-invasive to invasive phenotype in bladder tumors. Furthermore, we were able to identify specific miRNAs that are linked to postoperative outcome in patients with high grade NMI urothelial carcinoma of the bladder (UCB) that progressed to muscle-invasive (MI) disease

Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa

We examined gene expression in the blood of six females with anorexia nervosa (AN) before and after weight restoration using RNAseq. AN cases (aged 19-39) completed clinical assessments and had blood drawn for RNA at hospital admission (T1, < ~75% ideal body weight, IBW) and again at discharge (T2, ≥ ~85% IBW). To examine the relationship between weight restoration and differential gene expression, normalized gene expression levels were analyzed using a paired design. We found 564 genes whose expression was nominally significantly different following weight restoration (p < 0.01, 231 increased and 333 decreased). With a more stringent significance threshold (false discovery rate q < 0.05), 67 genes met criteria for differential expression. Of the top 20 genes, CYP11A1, C16orf11, LINC00235, and CPA3 were down-regulated more than two-fold after weight restoration while multiple olfactory receptor genes (OR52J3, OR51L1, OR51A4, OR51A2) were up-regulated more than two-fold after weight restoration. Pathway analysis revealed up-regulation of two broad pathways with largely overlapping genes, one related to protein secretion and signaling and the other associated with defense response to bacterial regulation. Although results are preliminary secondary to a small sample size, these data provide initial evidence of transcriptional alterations during weight restoration in AN