4-Dichloromethyl-4-methyl-5-(nitromethyl)cyclohex-2-enone

In the title compound, C9H11Cl2NO3, the six-membered ring adopts a screw-chair conformation. In the crystal, two different C—H...O hydrogen bonds involving the same acceptor atom connect the molecules into a chain extending along the c-axis direction

Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line

BACKGROUND Propolis is a complex resinous sticky substance that honeybees collect from buds and exudates of various plants. Owing to its versatile biological and pharmacological activities, propolis is widely used in medicines, cosmetics and foods. The aim of this study was to evaluate the cytotoxic and antioxidative effects of various ethanolic extracts of propolis (EEPs) on human colon cancer cell line HCT-116 and compare them with their composition determined by HPLC-DAD. RESULTS The most abundant flavonoids in all samples were chrysin, pinocembrin and galangin (12.697-40.811 mu gmg(-1)), while the main phenolic acids were caffeic acid, ferulic acid and isoferulic acid. Dose- and time-dependent inhibition of growth of HCT-116 cells was observed for all propolis samples, with IC50 values ranging from 26.33 to 143.09 mu gmL(-1). Differences in cytotoxic activity of propolis samples were associated with differences in their composition. All EEP samples reduced both superoxide anion radical and nitrite levels and also had strong DPPH-scavenging activity. CONCLUSION All tested propolis samples had pronounced cytotoxic and antioxidative activities.Peer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/3472

Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarin-derived ligand. Crystal structure of 4-hydroxy-3-(1-(p-tolylimino)ethyl)-2H-chromen-2-one-palladium(II) complex

The new coumarine derivative, 4-hydroxy-3-(1-(p-tolylimino)ethyl)-2H-chromen-2-one, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, H-1 and C-13 NMR spectroscopy. The proposed structure of the complex was confirmed on the basis of an X-ray structural study. In vitro antitumor activity for the ligand and complex was investigated. (C) 2013 Elsevier B.V. All rights reserved.Ministry of Education, Science and Technological Development of the Republic of Serbia [OI172016, OI172021, III41010, III41031]; Research Center of Serbian Academy of Arts and Sciences and the University of Kragujeva

Synthesis, characterization and cytotoxicity of a new palladium(II) complex with a coumarin-derived ligand. Crystal structure of 4-hydroxy-3-(1-(p-tolylimino)ethyl)-2H-chromen-2-one-palladium(II) complex

The new coumarine derivative, 4-hydroxy-3-(1-(p-tolylimino)ethyl)-2H-chromen-2-one, and corresponding palladium(II) complex have been synthesized and characterized by microanalysis, infrared, H-1 and C-13 NMR spectroscopy. The proposed structure of the complex was confirmed on the basis of an X-ray structural study. In vitro antitumor activity for the ligand and complex was investigated. (C) 2013 Elsevier B.V. All rights reserved.Ministry of Education, Science and Technological Development of the Republic of Serbia [OI172016, OI172021, III41010, III41031]; Research Center of Serbian Academy of Arts and Sciences and the University of Kragujeva