Efficacy of drugs in controlling microalbuminuria of diabetic nephropathy

Background: Beneficial effect in reducing microalbuminuria of diabetic nephropathy with angiotensin converting enzyme (ACE) inhibitor and angiotensin II receptor blockers (ARB) is proven. This study has directly compared the renoprotective effects of ARB and ACE inhibitors in persons with type-2 diabetes.Methods: In this prospective, double-blind, controlled trial, 100 patients with type 2 diabetes mellitus were chosen and randomly assigned to either receive ACE inhibitor (ramipril 5 mg, 50 patients) or ARB (losartan 50 mg, 50 patients). The endpoint was a reduction in 24 hrs urine microalbuminuria after a period of 3 months treatment. Results: At the end of 3 months treatment, the mean reduction of 24 hrs urine microalbuminuria in the ramipril group was 25 mg as compared to 38 mg in the losartan group; (t value=1.11, p=0.27). There was no statistical difference in the mean reduction when compared between the two groups. Significant reduction of blood pressure especially systolic blood pressure was noted in the losartan group as compared to those who received ramipril.Conclusion: Losartan was not inferior to ramipril in providing renoprotection in subjects with type 2 diabetes and early nephropathy. Losartan showed a significant reduction in systolic blood pressure, though not much reduction was seen with ramipril. Despite this, both drugs have shown a reduction in microalbuminuria, which supports the fact that reduction in microalbuminuria is independent of the antihypertensive action of ramipril or losartan

Evaluation of Bag of Visual Words for Category Level Object Recognition

Object recognition in a large scale collection of images has become an important application in machine vision. The recent advances in the object or image recognition for classification of objects shows that Bag-of-visual words approach is a better method for image classification problems. In this work, the effect of different possible parameters and performance evaluation of Bag of visual words approach in terms of their recognition performance such as Accuracy rate, Precision and F1 measure using 8 different classes of real world datasets that are commonly used in restaurant applications is explored. The system presented here is based on visual vocabulary. Features are extracted, clustered, trained and evaluated on an image database of 1600 images of different categories. To validate the obtained results,a performance evaluation on vehicle datasetsunder SURF and SIFT descriptors with Kmeans and K-medoid clustering and KNN classifier has been made. Among these SURF K-means performs better

Sonographic assessment of fetal head deflexion using occiput: spine angle measured during first stage of labour and its role in predicting the mode of delivery among nulliparous women

Background: The attitude of the fetal head during labour significantly influences the progress and outcome of delivery and is mainly diagnosed by vaginal examination during labour. The aim of the study was to quantify the extent of deflexion of the fetal head by measuring the fetal occiput spine angle (OSA) through transabdominal ultrasonography in the first stage of labour and to determine whether the fetal OSA can predict the mode of delivery.Methods: We conducted a prospective observational study on 145 nulliparous uncomplicated singleton pregnant women without occiput-posterior position of the fetus during active labour. The OSA was measured as the angle between the two tangential lines to the occipital bone and the vertebral body of the first cervical spine, during active labour and monitored until delivery. Intra- and interobserver reproducibility of the OSA measurement and the correlation between the OSA and mode of delivery were also evaluated.Results: For the study population, the mean value of the OSA measured in the active phase of the first stage was 124.2±11.5⁰. The OSA measurement showed excellent intraobserver agreement (r = 0.82; 95% confidence interval [95% CI] 0.70-0.80) and fair-to-good interobserver agreement (r = 0.62; 95% CI 0.51-0.71).  The mean OSA was significantly less for the group of patients who required conversion to cesarean section due to labour arrest (n=32) as compared to those who had vaginal delivery (n=113) (116.25±9.2⁰ versus 126.53±11.1⁰, P<0.01). An OSA of ≥121° was associated with vaginal delivery in 80.5% (91/113) of women, whereas 87.5% (28/32) of the women who delivered by cesarean section had an OSA <121⁰.Conclusions: Measurement of the OSA, by sonography is feasible, reproducible and an objective tool to assess the degree of fetal head deflexion during labour and to predict the mode of delivery

Studies on soil fertility status of coffee growing regions in Wayanad district

Top soil in Wayanad region is prone to disturbance and erosion, as the coffee growers’ practice scraping, scuffling and cover digging. It isnecessary to conserve the inherent fertility of top soil by minimum disturbance during farming operations. Otherwise soil deterioration can become one of the major constraints for crop production in the present day exploitative cultivation of plantation crops. It is well known that nutrient availability is influenced by their distribution in the soil as well as other soil characteristics. Soil fertility is the key to meet the nutrient requirement of the crops. Soil test based nutrient management will increase the crop productivity there by helping to save the fertility. The study, carried out to understand the fertility status of the coffee soils, revealed a higher acidity (98%) with deficiencies of calcium (32%), magnesium (96%) and boron (31%) limiting the coffee productivity in the district. The coffee area in the district is strongly acidic (69%) due to lack of liming and continuous use of acid producing fertilizers. Fifty per cent of soil sampleswere high in phosphorus which in turn impair the nutrient balance and affects micronutrient absorption by plants. Deficiency of calcium and magnesium affects uptake of other nutrients which upsets cellular functions. In coffee, boron deficiency will reduce the productivity by affecting flowering and fruit set. Amelioration of soil acidity and optimal use of major, secondary and micronutrients are must to enhance coffee productivity in the district. Application of manures and fertilizers based on soil test values will save the fertilizers and also sustain the soil health. Integrated management of plant nutrients is essential to achieve sustainable coffee crop production

Improved control strategy of DFIG-based wind turbines using direct torque and direct power control techniques

This paper presents different control strategies for a variable-speed wind energy conversion system (WECS), based on a doubly fed induction generator. Direct Torque Control (DTC) with Space-Vector Modulation is used on the rotor side converter. This control method is known to reduce the fluctuations of the torque and flux at low speeds in contrast to the classical DTC, where the frequency of switching is uncontrollable. The reference for torque is obtained from the maximum power point tracking technique of the wind turbine. For the grid-side converter, a fuzzy direct power control is proposed for the control of the instantaneous active and reactive power. Simulation results of the WECS are presented to compare the performance of the proposed and classical control approaches.Peer reviewedFinal Accepted Versio

Selection of accessions from minicore to improve disease resistance in groundnut

A mini core subset of world germplasm comprising 188 accessions was evaluated for late leaf spot, rust and seed colonization by A. flavus. Accessions highly resistant to late leaf spot (ICG 2857, ICG 8760, ICG 12625, ICG 13787, ICG 12672, ICG 14475 and ICG 11426), rust (ICG 4746, ICG 6706, ICG 11088 and ICG 11426) and A. flavus (ICG 14985, ICG 6025, ICG 3673, ICG 12625, ICG 13787 and ICG 8760) were identified. Some accessions (ICG 12625, ICG 13787, ICG 11426 and ICG 8760) combined resistance to at least two diseases. The identified accessions along with three popular cultivars (GPBD 4, TAG 24 and JL 24) were subjected to RAPD assay using twenty primers to assess molecular diversity. The genetic similarity (Sij) ranged from 0.64 to 0.92. Accessions ICG 6706, 14475 and 8760 were more diverse with the popular varieties. The information generated in this study will be of great value to plant breeders in their effort to develop varieties resistant to fungal diseases through hybridization

Arcanobacterium haemolyticum associated with pyothorax: case report

Arcanobacterium haemolyticum has an established role in the etiology of human pharyngitis. There are increasing reports of systemic infections caused by this organism. From India, we report the first case of Arcanobacterium haemolyticum causing pyothorax in an immunocompetent adolescent male patient. The probable mode of infection is also discussed. The role of A. hemolyticum as an animal pathogen needs further study

Energy poverty, institutional reform and challenges of sustainable development: the case of India

This paper assesses recent efforts by the Indian Government to tackle energy poverty and sustainable development. It focuses on the new integrated energy policy, and initiatives to disseminate improved cookstoves and develop energy alternatives for transport. The success of government initiatives in cleaner biomass cookstoves and village electrification has historically been limited, and institutional reforms in the 2000s promoted market-led and ‘user-centred’ approaches, and encouraged biofuels as a ‘pro-poor’ route to rural development and energy security. The paper argues that such interventions have reopened tensions and conflicts around land-use, intra-community inequalities and the role of corporate agendas in sustainable energy

Human protein reference database—2006 update

Human Protein Reference Database (HPRD) () was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data