Complete response of skull base inverted papilloma to chemotherapy: Case report.

BackgroundInverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy and potentially difficult surgical access.ObjectivesWe reported a unique case of a massive frontal sinus IP that presented with intracranial and orbital extension, with near resolution after chemotherapy.MethodsA retrospective case review of a patient with a frontal sinus IP treated at a tertiary academic medical center.ResultsA 75-year-old male patient presented with nasal obstruction, purulent nasal discharge, and a growing left supraorbital mass. Endoscopy demonstrated a mass that filled both frontal and ethmoid sinuses, with orbital invasion. There also was substantial erosion of the posterior table, which measured 1.73 × 1.40 cm. A biopsy specimen demonstrated IP with carcinoma in situ. The patient was deemed unresectable on initial evaluation and, subsequently, underwent chemotherapy (carboplatin and paclitaxel). The tumor had a dramatic response to chemotherapy, and the patient elected for definitive surgery to remove any residual disease. During surgery, only a small focus of IP was found along the superior wall of the frontal sinus. No tumor was found elsewhere, including at the site of skull base erosion. The final pathology was IP without carcinoma in situ or dysplasia.ConclusionThis was the first reported case of chemotherapeutic "debulking" of IP, which facilitated surgical resection, despite substantial intracranial and orbital involvement. Although nearly all IPs can be treated surgically, rare cases, such as unresectable tumors, may benefit from systemic chemotherapy

Fracture toughness and crack-resistance curve behavior in metallic glass-matrix composites

Nonlinear-elastic fracture mechanics methods are used to assess the fracture toughness of bulk metallic glass (BMG) composites; results are compared with similar measurements for other monolithic and composite BMG alloys. Mechanistically, plastic shielding gives rise to characteristic resistance-curve behavior where the fracture resistance increases with crack extension. Specifically, confinement of damage by second-phase dendrites is shown to result in enhancement of the toughness by nearly an order of magnitude relative to unreinforced glass

Spin Dynamics in the LTT Phase of ~1/8 Doped Single Crystal La_{1.67}Eu_{0.2}Sr_{0.13}CuO_4

We present La and Cu NMR relaxation measurements in single crystal La_{1.67}Eu_{0.2}Sr_{0.13}CuO_4. A strong peak in the La spin-lattice relaxation rate observed in the spin ordered state is well-described by the BPP mechanism[1] and arises from continuous slowing of electronic spin fluctuations with decreasing temperature; these spin fluctuations exhibit XY-like anisotropy in the ordered state. The spin pseudogap is enhanced by the static charge-stripe order in the LTT phase.Comment: Four pages, three figure

Study of the neutron star structure in strong magnetic fields including the anomalous magnetic moments

We study the effects of strong magnetic fields on the neutron star structure. If the interior field of a star is on the same order of the surface field currently observed, the influences of the magnetic field on the star mass and radius are negligible. If one assumes that the internal magnetic field can be as large as that estimated from the scalar virial theorem, considerable effects can be induced. The maximum mass of stars is arisen substantially while the central density is largely suppressed. For two equal-mass stars the radius of the magnetic star can be larger by about 10% $\sim$ 20% than the nonmagnetic star.Comment: 26 pages, 5 postscript figures; replaced by the revised version, Chin. J. Astron. Astrophys., accepte

Speckle-visibility spectroscopy: A tool to study time-varying dynamics

We describe a multispeckle dynamic light scattering technique capable of resolving the motion of scattering sites in cases that this motion changes systematically with time. The method is based on the visibility of the speckle pattern formed by the scattered light as detected by a single exposure of a digital camera. Whereas previous multispeckle methods rely on correlations between images, here the connection with scattering site dynamics is made more simply in terms of the variance of intensity among the pixels of the camera for the specified exposure duration. The essence is that the speckle pattern is more visible, i.e. the variance of detected intensity levels is greater, when the dynamics of the scattering site motion is slow compared to the exposure time of the camera. The theory for analyzing the moments of the spatial intensity distribution in terms of the electric field autocorrelation is presented. It is demonstrated for two well-understood samples, a colloidal suspension of Brownian particles and a coarsening foam, where the dynamics can be treated as stationary. However, the method is particularly appropriate for samples in which the dynamics vary with time, either slowly or rapidly, limited only by the exposure time fidelity of the camera. Potential applications range from soft-glassy materials, to granular avalanches, to flowmetry of living tissue.Comment: review - theory and experimen

Energy-Efficient Motion Planning for Multi-Modal Hybrid Locomotion

Hybrid locomotion, which combines multiple modalities of locomotion within a single robot, enables robots to carry out complex tasks in diverse environments. This paper presents a novel method for planning multi-modal locomotion trajectories using approximate dynamic programming. We formulate this problem as a shortest-path search through a state-space graph, where the edge cost is assigned as optimal transport cost along each segment. This cost is approximated from batches of offline trajectory optimizations, which allows the complex effects of vehicle under-actuation and dynamic constraints to be approximately captured in a tractable way. Our method is illustrated on a hybrid double-integrator, an amphibious robot, and a flying-driving drone, showing the practicality of the approach

Easy on that trigger dad: a study of long term family photo retrieval

We examine the effects of new technologies for digital photography on people's longer term storage and access to collections of personal photos. We report an empirical study of parents' ability to retrieve photos related to salient family events from more than a year ago. Performance was relatively poor with people failing to find almost 40% of pictures. We analyze participants' organizational and access strategies to identify reasons for this poor performance. Possible reasons for retrieval failure include: storing too many pictures, rudimentary organization, use of multiple storage systems, failure to maintain collections and participants' false beliefs about their ability to access photos. We conclude by exploring the technical and theoretical implications of these findings