Validation of Purgation Therapy (Bhedhi) in Pacifying Vatha Kuttram

Patient’s with the symptoms of Vatha were enrolled in the study. • The author had collected, the review literature for Vatham,Virechanam from classical siddha literatures and Modern aspect of purgation therapy from various texts, Published articles. • Case sheet and proforma was maintained for all 40 cases. • Derangement of Uyirthathukkal and Udalthathukkal in the disease had been discussed. • Ennvagithervugal had studied in detail and their interpretation had done. • Naadi, Neikuri, Manikkadai Nool before and after treatment were discussed. • There is no obvious change in Naadi before and after treatment was noticed among patients. • ManikkadaiNool also shows changes in patients before and after treatment but the results were insignificant. • Based on patient’s satisfactory rate, about 23% of patients showed better and good relief and about 10% of patients reported to have slight relief. • Neikuri shows better results after treatment of Vatham was decreased in many patients who showed vatham predominant Neikuri pattern before treatment. • Better results were shown in patients who had taken oil bath 3 days continuously before taking purgation medicine • One patient with RA Positive had showed the result of RA Negative after 1 week of taking purgation. • A patient with Trigeminal Neuralgia showed a better relief after getting purgation for 3 days

Effectiveness of Nursing Care on Home Management of Dysmenorrhoea among the Adolescent Girls at Venmalagaram

The present study was conducted to find out the effectiveness of home management of dysmenorrhoea among adolescent girls. The study was evaluative research design and total 30 adolescent girls with dysmenorrhoea were selected as per inclusion criteria. Adolescent girls were selected from Venmalagarm with the complaints of dysmenorrhoea. The objective of the study is to assess the health status of adolescent girls with dysmenorrhoea, to evaluate the effectiveness of nursing care on home management of dysmenorrhoea among the adolescent girls, to find out the correlation between the selected demographic variables with the effectiveness of nursing care on home management of dysmenorrhoea among the adolescent girls. CONCLUSION: From the assessment of adolescent girls with dysmenorrhoea showed that 60% were in severe health deterioration 30% were in moderate health deterioration and 10% were in mild health deterioration. From the evaluation of adolescent girls with dysmenorrhoea with in three days after comprehensive nursing care as per protocol showed that majority of them were 67% in mild health deterioration 43% were in moderate health deterioration none of them was in severe health deterioration. Most of them developed severe lower abdominal pain, back pain, nausea and vomiting, affected mood, inadequate self care activities. Nursing care would be implemented based on needs with the help of developed protocols. In evaluation of nursing care the patients were in reduced state of pain, assumed in self care activities and had improvement in health status. IMPLICATIONS: Only prompt and effective nursing measures of assessment and intervention along with treatment regiment can prevent the complications. Nurses those who are in health care services play a vital role in management of adolescent girls with dysmenorrhoea. The findings of the study have several implications in nursing as follows. NURSING PRACTICE: ❖ It preventive as well as curative aspects the emphasis should be given the present trend in the health care delivery system. ❖ The study will create awareness among the nurses in identifying the cause of infertility. ❖ The developed nursing protocol will help in planning nursing intervention in adolescent girls with dysmenorrhoea. ❖ The present nursing protocol can be used by the nurses in various health care setting. NURSING EDUCATION: ❖ The developed nursing protocol can be used to teach the novice nurse in various healthcare settings regarding the nursing assessment and intervention of adolescent girls with dysmenorrhoea. ❖ The nurse educator whenever they plan to provide instruction regarding care of adolescent girls with dysmenorrhoea should be provided opportunity to develop the skill and attitude in handling the adolescent girls with dysmenorrhoea. ❖ The leader in nursing care confronted to understand the health needs of the most vulnerable by effective organization and management. ❖ The nurse administrator should take active part in health policy making, developing protocol, procedure and standing orders related to care of adolescent girls with dysmenorrhoea. NURSING ADMINISTRATION: Nursing administrator should encourage his / her subordinate to do further research on the problems of adolescent girls with dysmenorrhoea. Findings of this study help nurses administrators to allocate resources to do further studies in nursing care of adolescent girls with dysmenorrhoea. Nurse administrator can also arrange a mass health education programme in schools and colleges to create awareness in prevention and home management of dysmenorrhoea. Through research findings the institutions can formulate policy and procedure on care of adolescent girls with dysmenorrhoea at given setup by conducting further research in this area to standardize the nursing. Nursing administrator can also make recommendion to staff nurses to follow guidelines as per protocol in providing care to the adolescent girls with dysmenorrhoea. NURSING RESEARCH: The study findings will serve as a background for further study in the care of adolescent girls with dysmenorrhoea. A study helps to provide effective nursing care for adolescent girls with dysmenorrhoea. RECOMMENDATIONS: Similar study can be done for large number of samples. ❖ A comparative study can be conducted between urban and rural community. ❖ A comparative study can be conducted between working and school going adolescent girls. ❖ A descriptive study to assess the knowledge regarding home management for dysmenorrhoea. ❖ A comparative study to assess the effectiveness of yoga and exercise for management of dysmenorrhoea. ❖ The experimental study was done for new intervention under alternative system of medicine. ❖ Comparative study can be done on different age group of reproductive age group women

STUDY ON RECYCLED AGGREGATE CONCRETE WITH BLENDED GGBS

Abstract With the rapid growth in construction activities, it is important to assess the amount of construction and demolition waste being generated and analyse the practices needed to handle this waste from the point of waste management and disposal and also with regard to waste utilization in concrete from the sustainability aspects. Construction and Demolition (C&D) waste constitutes a major portion of total solid waste production in the world, and most of it is used in landfills. Research by concrete engineers has clearly suggested the possibility of appropriately treating and reusing such waste as aggregate once again in concrete, especially in applications such as bed concrete and in road beds for pavement i.e. where works are of less importance as regards to the strength. The use of such waste as recycled aggregate in concrete can be useful for both environmental and economic aspects in the construction industry. In present study, five concrete mixes were used; first mix had only natural coarse aggregate and in remaining mixes natural coarse aggregate was partial replaced by 10%, 20%, 30% and 40% recycled coarse aggregate. In all the mix cement was replaced by 10% GGBS. Here an attempt is made to assess the strength and durability characteristics of concrete made using construction and demolition waste recycled coarse aggregate

Hybrid Cryptography and Steganography-Based Security System for IoT Networks

Despite the fact that many IoT devices are publicly accessible to everyone on the network, understanding the security risks and threats posed by cyber attacks is critical; as a result, it should be safeguarded. Plain text is constructed into encrypted text, before being delivered by using cryptography, and is then reconstructed back to plain text after receiving a response from the recipient. The steganography technique can be used to hide sensitive information incorporated in a text, audio, or video file. One approach is to hide data in bits that correspond to successive rows of pixels with the same color in an image file.  As a consequence, the image file retains the original's appearance while also containing "noise" patterns made out of common, unencrypted data. To do this, the encrypted data is subtly applied to the redundant data. In this work, it is suggested that IoT network data be encrypted using cryptography, and that an encrypted message be concealed inside an image file using steganography. Additionally, it is suggested to enhance the number of bits that may be stored within a single picture pixel.  The payload that may be sent through an image is significantly increased by incorporating Convolutional Neural Networks into the classic steganography technique. In this work, we propose, design, and train Convolutional Neural Networks (CNN) to enhance the amount of data that can be securely encrypted and decrypted to show the original message

Formulation And Evaluation Of Mouth Dissolving Tablets Of Amoxapine

The objective of the present study is to design and formulate orodispersible tablets of Amoxapine using novel Co-processed superdisintegrants by employing direct compression method. Amoxapine is used to treat symptoms of depression. Amoxapine is a class II drug with high permeability and low solubility. There is a need to develop a formulation of Amoxapine that will enhance the bioavailability of the drug by decreasing the disintegration time.  Thus improves patient compliance generate rapid response enhances bioavailability and also reduces dose of drug. In this study ODTs are prepared by direct compression method using novel super disintigrants in different proportions .The powder blend is subjected to pre compression parameters including bulk density, true density, tapped density, cars index, Hausner’s ratio and angle of repose. The formulations are evaluated for weight variation, hardness, wetting time, water absorption test, disintegration time and in vitro dissolution studies and all formulations complies its Pharmacopoeial standards. The tablets are evaluated and the results compared for all four super disintigrants revealed cross povidone to be the most efficious super disintigrants to formulate mouth dissolving tablets of Naproxen sodium as suggested by the dispersion time , disintegration time and drug dissolution profile

Carbohydrate specificity and salt-bridge mediated conformational change in acidic winged bean agglutinin

Structures of two crystal forms of the dimeric acidic winged bean agglutinin (WBAII) complexed with methyl-α-D-galactose have been determined at 3.0 Å and 3.3 Å resolution. The subunit structure and dimerisation of the lectin are similar to those of the basic lectin from winged bean (WBAI) and the lectin from Erythrina corallodendron (EcorL). The conformation of a loop and its orientation with respect to the rest of the molecule in WBAII are, however, different from those in all the other legume lectins of known structure. This difference appears to have been caused by the formation of two strategically placed salt bridges in the former. Modelling based on the crystal structures provides a rationale for the specificity of the lectin, which is very different from that of WBAI, for the H-antigenic determinant responsible for O blood group reactivity. It also leads to a qualitative explanation for the thermodynamic data on sugar-binding to the lectin, with special emphasis on the role of a tyrosyl residue in the variable loop in the sugar-binding region in generating the carbohydrate specificity of WBAII

Plasmepsin inhibitors: design, synthesis, inhibitory studies and crystal structure analysis

Plasmepsin group of enzymes are key enzymes in the life cycle of malarial parasites. As inhibition of plasmepsins leads to the parasite's death, these enzymes can be utilized as potential drug targets. Although many drugs are available, it has been observed that Plasmodium falciparum, the species that causes most of the malarial infections and subsequent death, has developed resistance against most of the drugs. Based on the cleavage sites of hemglobin, the substrate for plasmepsins, we have designed two compounds (p-nitrobenzoyl-leucine-β -alanine and p-nitrobenzoyl-leucine-isonipecotic acid), synthesized them, solved their crystal structures and studied their inhibitory effect using experimental and theoretical (docking) methods. In this paper, we discuss the synthesis, crystal structures and inhibitory nature of these two compounds which have a potential to inhibit plasmepsins

Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure

Until recently, it has only been possible to grow crystals of peanut lectin when complexed with sugar ligands. It is now shown that it is possible to grow peanut lectin crystals at acidic pH in the presence of oligopeptides corresponding to a loop in the lectin molecule. Crystals have also been prepared in the presence of these peptides as well as lactose. Low-pH crystal forms of the lectin-lactose complex similar to those obtained at neutral pH have also been grown. Thus, crystals of peanut lectin grown under different environmental conditions, at two pH values with and without sugar bound to the lectin, are now available. They have been used to explore the plasticity and hydration of the molecule. A detailed comparison between different structures shows that the lectin molecule is sturdy and that the effect of changes in pH, ligand binding and environment on it is small. The region involving the curved front β-sheet and the loops around the second hydrophobic core is comparatively rigid. The back β-sheet involved in quaternary association, which exhibits considerable variability, is substantially flexible, as is the sugar-binding region. The numbers of invariant water molecules in the hydration shell are small and they are mainly involved in metal coordination or in stabilizing unusual structural features. Small consistent movements occur in the combining site upon sugar binding, although the site is essentially preformed

Phase transfer of platinum nanoparticles from aqueous to organic solutions using fatty amine molecules

In this report we demonstrate a simple process based on amine chemistry for the phase transfer of platinum nanoparticles from an aqueous to an organic solution. The phase transfer was accomplished by vigorous shaking of a biphasic mixture of platinum nanoparticles synthesised in an aqueous medium and octadecylamine (ODA) in hexane. During shaking of the biphasic mixture, the aqueous platinum nanoparticles complex via either coordination bond formation or weak covalent interaction with the ODA molecules present in the organic phase. This process renders the nanoparticles sufficiently hydrophobic and dispersible in the organic phase. The ODA-stabilised platinum nanoparticles could be separated out from hexane in the form of a powder that is readily redispersible in weakly polar and non-polar organic solvents. The ODA-capped platinum nanoparticles show high catalytic activity in hydrogenation reactions and this is demonstrated in the efficient conversion of styrene to ethyl benzene. The nature of binding of the ODA molecules to the platinum nanoparticles surface was characterised by thermogravimetry, transmission electron microscopy (TEM), X-ray photoemission spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR)

Crystal structure of the peanut lectin - T-antigen complex. Carbohydrate specificity generated by water bridges

Peanut lectin binds with high specificity to the tumour­ associated disaccharide GaI.81-3GaINAc, generally known as T-antigen. The crystal structure of the complex of the lectin with the disaccharide has been determined at 2.5 A resolution. Comparison of the structure with that of the corresponding complex with lactose reveals that the specificity of the lectin for T-antigen is generated primarily by two specific water­ mediated interactions, probably the first instance where water-bridges have been demonstrated to be responsi­ ble for generating specificity in protein-carbohydrate interactions. The elucidation of the structure of peanut lectin- T -antigen complex also provides a framework for exploring peanut lectin-based prognosis and diag­ nosis of certain types of carcinoma