Ascending colon cancer and situs inversus totalis: a case report in Sanglah general hospital Denpasar, Bali

Situs inversus totalis is a rare congenital condition that occurs in one out of 4,000-20,000 people, characterized by complete transposition of the thoracic and abdominal viscera that creates a mirror image. The etiologic nature of this anomaly is not known. Situs inversus totalis is typically associated with normal life expectancy unless a gastrointestinal or cardiac anomaly is present. This anomaly is not a premalignant condition. Association between colorectal cancer and situs inversus totalis is rare. The transposition of the organs imposes special demands on the diagnostic and technical skills of the surgeon. We report a case of colorectal cancer and situs inversus totalis in a 51-year-old male presenting with intermittent left lower abdominal pain and change of bowel habit since 9 months before admission. We found a palpable solid mass on the left paraumbilical region, mobile, with no tenderness. Laboratory results show moderate anemia with high CEA level. Fecal Occult Blood Test (FOBT) was positive. Plain chest radiography showed suspected situs inversus. We found descending colon tumor on colonoscopy, with histopathology result intramucosal carcinoma. The contrast abdomen CT scan showed situs inversus and irregular thickening on ascending colon with partial stenosis. We performed extended left hemicolectomy and intraoperative we found a mass in the hepatic flexure of the colon with no sign of lymph node and liver metastases. The histopathologic diagnosis was adenocarcinoma moderately differentiated. The patient was diagnosed with adenocarcinoma of ascending colon T3N0M0, stage II

Association of body mass, gender and race with heart failure primarily due to hypertension

OBJECTIVES: This study was performed to determine the association between clinical characteristics, particularly body mass and race, and the likelihood of hypertension as the primary etiology for heart failure (HTNCM). BACKGROUND: Although held to be important in the development of heart failure, the clinical characteristics predictive of HTNCM have not been well delineated. METHODS: The study analysis was conducted using 680 patients from the University of North Carolina Heart Failure Database. This data set is racially diverse (44% African-American) and contains data concerning baseline clinical characteristics and cardiac function in patients with and without HTNCM. Logistic regression techniques determined independent predictors of HTNCM among the entire study population as well as the subgroup of study patients with hypertension. RESULTS: Hypertension was present in 51% of the study patients but was the primary etiology of heart failure in only 25%. Body mass, race, gender and baseline systolic blood pressure were identified as significant independent predictors of the likelihood of HTNCM (all p < 0.001). These characteristics were predictors in the total study population and also in the subgroup of study patients with hypertension. CONCLUSIONS: Hypertension remains a common etiologic factor for the development of heart failure but was the primary cause of heart failure in a minority of study patients. However, the presence of increased body mass, female gender, African-American ethnic origin or elevated baseline systolic blood pressure significantly increased the likelihood of HTNCM

Formative Process of Regional Concentration in a JapaneseWhaling Fishing Ground in the Edo Period : Analysis of the Particularity of the SaikaiWhaling Industry Area

The whaling industry in early modern Japan was the greatest fishery in Edo period. At the time, whaling was mainly conducted in four districts (i.e. Kishu, Tosa, Tyosyu, and Saikai). whaling industry was carried on by large−scaled industrial management object which was called “whaling organization (kujira−gumi)”. I have for my object to make the regional concentration process of the whaling fishing ground in Goto Han clear about a whaling industry in Goto Han who didn’t also aim so much in the Saikai area this time. That was separated 3 periods in an extended period from Enpo and a Genroku period to Bunsei and a Tenpo period here in particular, and a change and the development process of the “whaling organization (kujira−gumi)” in Goto Han were considered, also considering a relation with a financial problem of Goto Han. When saying a whaling industry in Saikai area in the Edo Period up to now, I was very strong in an image of an achievement of Fukazawagumi of Omura han and a big “whaling organization (kujira−gumi)” of 3, Nakao, Doi and Mastomi. On the other hand, activity of the Eguchi family of Arikawa village was learned about in Goto Han, too. But development of the “whaling organization (kujira−gumi)” of the former and the latter has been talked on separately without associating. But, the Saikai area “whaling organization (kujira−gumi)”which can have talked on individual “whaling organization (kujira−gumi)” management and its development process independently respectively up to now was intermingled in a whaling fishing ground of Goto Han actually by this analysis. Moreover it was revealed that habitat segregation was done by a fishing ground as for the latter period in the Edo Period. And when it was considered from a geographical side, regional centralization in a whaling fishing ground in Nishiumi area was seen, and moreover it was revealed that a differentiation phenomenon in a winter fishing ground and a fishing ground in spring has formed. It’s understood to be different from a whaling industry area of 3, other Kishu, Tosa and Nagasu from the thing.In other words, it was being enabled that management activity in fishing ground area of sea of a whaling industry in this Saikai area is formed beyond the Han. Development of a whaling industry management was seen aggressively in the the inter−han whaling industry which is the characteristic of the Saikai whaling industry area here. That led to successive development by the “whaling organization (kujira−gumi)” from formation in the first term in the Edo Period in this whaling industry area to the latter period. Above, the geographical angle as well as the historical science−like angle of the ancient document emphasis were taken in by the main subject. And I made it clear about formative process in a whaling industry area in Japan in the Edo Period when I had almost no studies up to now by that. Moreover the local industry as a large− scale whaling industry and concerning in Han fief were made clear

Porfirinas de manganeso como inactivadores de peroxinitrito: evaluación cinética y efectos sobre blancos moleculares

Hemos caracterizado la cinética de reacción de un conjunto de porfirinas de manganeso (MnPorfirinas) solubles en agua frente a peroxinitrito (ONOO–) y radical carbonato (CO3·–). La reacción, entre ONOO– y el complejo de MnIII, tiene constantes de velocidad entre 105 y 107 M-1 s-1 a 37 ºC con un comportamiento sigmoide en función del pH, pKa aparentes cercanos al del par ONOOH/ONOO– y máximos a pH alcalino. La reacción produce el complejo O=MnIV y ·NO2. Los valores de estas constantes de velocidad tienen una relación lineal de energía libre con parámetros fisicoquímicos de la porfirina tales como el potencial redox del par MnIII/MnII o la acidez de Brønsted de los nitrógenos pirrólicos o de las moléculas de agua axiales. La reacción, entre ONOO– y el complejo de MnII, tiene constantes de velocidad <106 M-1 s-1 a pH 7.4 y 37 ºC y produce estequiométricamente O=MnIV y NO2–. La reacción, entre CO3·– y el complejo de MnIII tiene constantes de velocidad extrapoladas a pH neutro entre 2 y 12 x 108 M-1 s-1 con un comportamiento ácido base congruente con la ionización de las moléculas axiales de agua presentes en el complejo. La reacción entre CO3·– y el complejo de MnII tiene constantes de velocidad a pH = 10.4 entre 1 y 5 x 109 M-1 s-1. En ambos casos el CO3·– produce oxidaciones por un electrón.Los complejos de O=MnIV se reducen en forma rápida con ascorbato o urato hasta MnIII en presencia de oxígeno y, con bajas concentraciones de O2, la reducción puede llegar hasta MnII si los reductores son flavoenzimas reducidas, entre ellas succinato deshidrogenasa y NADH deshidrogenasa de la cadena mitocondrial de transporte de electrones. Estas reacciones de reducción completan dos posibles ciclos para catalizar la reducción de ONOO– o CO3·– con una eficiencia suficiente para proteger blancos biológicos en concentraciones micromolares de MnPorfirinas.Se presentan resultados de uso del ciclo catalítico MnIII/MnIV con urato como reductor en la protección de LDL in vitro y del ciclo catalítico MnII/MnIV con succinato/succinato deshidrogenasa como reductor para proteger actividades enzimáticas de partículas submitocondriales in vitro.Los resultados obtenidos indican que la interacción de MnPorfirinas con reductores biológicos y en particular con flavoenzimas mitocondriales podría explicar en parte la actividad protectora de estos compuestos en diversos modelos de patología vinculada con estrés oxidativo y disfunción mitocondri

Multiplicando experiencias : La participación en los proyectos de comunicación

El presente trabajo se enmarca dentro del área de tesis de producción, ya que se trata de la creación de una cartilla de divulgación/consulta con técnicas participativas para el abordaje de la participación en los proyectos de comunicación, recuperando para la realización del material experiencias realizadas por equipos de alumnos de la Facultad de Periodismo y Comunicación Social, a través de la sistematización. Con este proyecto de tesis buscamos recuperar antecedentes que son de utilidad para la disciplina, reuniendo, analizando y organizando algunas experiencias en donde se implementaron técnicas participativas para la superación de problemáticas en espacios y proyectos de comunicación, obteniendo buenos resultados. La importancia que le otorgamos a las técnicas participativas se debe a considerarlas eje central del paradigma desde el que entendemos la comunicación: como producción social de sentido.Facultad de Periodismo y Comunicación Socia

Differential parameters between cytosolic 2-Cys peroxiredoxins, PRDX1 and PRDX2

Peroxiredoxins are thiol-dependent peroxidases that function in peroxide detoxification and H2O2 induced signaling. Among the six isoforms expressed in humans, PRDX1 and PRDX2 share 97% sequence similarity, 77% sequence identity including the active site, subcellular localization (cytosolic) but they hold different biological functions albeit associated with their peroxidase activity. Using recombinant human PRDX1 and PRDX2, the kinetics of oxidation and hyperoxidation with H2O2 and peroxynitrite were followed by intrinsic fluorescence. At pH 7.4, the peroxidatic cysteine of both isoforms reacts nearly tenfold faster with H2O2 than with peroxynitrite, and both reactions are orders of magnitude faster than with most protein thiols. For both isoforms, the sulfenic acids formed are in turn oxidized by H2O2 with rate constants of ca 2 × 103 M−1 s−1 and by peroxynitrous acid significantly faster. As previously observed, a crucial difference between PRDX1 and PRDX2 is on the resolution step of the catalytic cycle, the rate of disulfide formation (11 s−1 for PRDX1, 0.2 s−1 for PRDX2, independent of the oxidant) which correlates with their different sensitivity to hyperoxidation. This kinetic pause opens different pathways on redox signaling for these isoforms. The longer lifetime of PRDX2 sulfenic acid allows it to react with other protein thiols to translate the signal via an intermediate mixed disulfide (involving its peroxidatic cysteine), whereas PRDX1 continues the cycle forming disulfide involving its resolving cysteine to function as a redox relay. In addition, the presence of C83 on PRDX1 imparts a difference on peroxidase activity upon peroxynitrite exposure that needs further study.Fil: Dalla Rizza, Joaquín. Universidad de la Republica; UruguayFil: Randall, Lía M.. Universidad de la Republica; UruguayFil: Santos, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Ferrer Sueta, Gerardo. Universidad de la Republica; UruguayFil: Denicola, Ana. Universidad de la República; Urugua

One Aspect of the Whaling industry in the Hirado han Control area of the Early-modern Times －Research of Historical Materials of the Business Tax of the Masutomi Matazaemon Group－

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