20 research outputs found

    Movie S1 from Age-based soldier polyethism: old termite soldiers take more risks than young soldiers

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    Royal guard soldiers defending the royal chamber of a large field colony (colony code: MS150719E) Misawa, Aomori prefecture, Japan

    Movie S2 from Age-based soldier polyethism: old termite soldiers take more risks than young soldiers

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    A soldier blocking the entrance of the nest against a predatory ant Brachyponera chinensis

    Clinical Importance of Epstein–Barr Virus-Associated Gastric Cancer

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    Epstein–Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. EBVaGC has definite histological characteristics similar to gastric carcinoma with lymphoid stroma. Clinically, EBVaGC has a significantly low frequency of lymph node metastasis compared with EBV-negative gastric cancer, resulting in a better prognosis. The Cancer Genome Atlas of gastric adenocarcinomas proposed a molecular classification divided into four molecular subtypes: (1) EBVaGC; (2) microsatellite instability; (3) chromosomal instability; and (4) genomically stable tumors. EBVaGC harbors a DNA methylation phenotype, PD-L1 and PD-L2 overexpression, and frequent alterations in the PIK3CA gene. We review clinical importance of EBVaGC and discuss novel therapeutic applications for EBVaGC
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