テンネンカルダノールユライノカンキョウニヤサシイシンキバイオベースコウブンシノカイハツ

博士（工学）東京農工大

The Mediating Role of Operational and Environmental Performance in the Relationship between Green Supply Chain Management and Financial Performance

The study is carried out with an objective to explore the impact of green supply chain management on different performance measures such as environmental performance, operational performance and financial performance. In addition to that, the mediating role of operational performance and the environmental performance in the relationship between green supply chain management and the financial performance is also examined. The study has broached a new perspective, that is external and internal GSCM practices are essential in the SC strategies, as these practices facilitate firms in enhancing market share and profits only when jointly implemented, by improving ecological efficiency and minimizing environmental risks. Therefore, the objective of this paper is to examine the interrelationships between GSCM approaches, performance, and environmental drivers. SEM-PLS is used to achieve the research objective of the current study. The study which is on Indonesian is in author knowledge is among few pioneering studies exploring the interaction of green supply chain management as determinant of firm performance measures. This study will be helpful for policymakers and researchers in examining the link between supply chain management on different performance measures such as environmental performance, operational performance and financial performance for Indonesian settings

Internal Market Orientation and Supply Chain Visibility as the Antecedent of New Product Flexibility: Exploring Moderating Impact of Internal Integration

Objectives of current study are to examine the impact of Supply Visibility, market orientation and supply chain responsiveness on new product flexibility. Moreover, moderating role of internal integration is being examined in the current study as well. For current research, data collection was done with help of structured questionnaire from the customers of electronic sectors of Indonesia. The response rate of the current study is 53.5% which is significantly higher than the threshold level of 30%. In this research, we used two-step process for analyzing and describing the data analysis outcomes obtained through PLS-SEM. The result indicates that the all path is significant at p-value less than 0.05, and integration appears as a significant moderator. The present study adds on the previous literature regarding under study constructs. The results of the study ensure that improvement in internal market orientation, supply visibility enhances responsiveness in supply chain, which in turn increases the flexibility in new product making. Current study focuses on new product flexibility as an outcome of internal market orientation, supply visibility. While aligning all these supply chain strategies will significantly impact to reduce unnecessary supply chain costs.

Impact on Neurological Recovery of Transforaminal Debridement and Interbody Fusion versus Transpedicular Decompression in Combination with Pedicle Screw Instrumentation for Treating Thoracic and Lumbar Spinal Tuberculosis

Study DesignRetrospective study.PurposeTo compare the neurological outcome of transforaminal debridement and interbody fusion with transpedicular decompression for treatment of thoracic and lumbar spinal tuberculosis.Overview of LiteratureFew articles have addressed the impact of neurological recovery in patients with tuberculosis who were treated by two different operative methods via the posterior-only approach.MethodsClinical and radiographic results of one-stage posterior instrumented spinal fusion for treatment of tuberculous spondylodiscitis with neurological deficits were reviewed and analyzed from 2009 to 2013. The extensive (E) group consisted of patients who received transforaminal debridement and interbody fusion, whereas transpedicular decompression was performed on limited (L) group. Rapid recovery was improvement of at least one Frankel grade within 6 weeks after operation. Otherwise, it was slow recovery.ResultsAll 39 patients had improved neurological signs. The median follow-up period was 24 months. Proportionately younger patients (under 65 years of age) received extensive surgery (15 of 18, 83.3% vs. 11 of 21, 52.4%; p=0.04). The mean operative time and blood loss in the group E were higher than in the group L (both p<0.01). With regard to type of procedure, especially at thoracic and thoracolumbar spine, patients who underwent extensive surgery had rapid neurological recovery significantly different from those of limited surgery (p=0.01; Relative Risk, 3.06; 95% Confidence Interval, 1.13 to 8.29).ConclusionsTransforaminal debridement and interbody fusion provides more rapid neurological recovery in patients with thoracic and thoracolumbar spinal tuberculosis compared to transpedicular decompression

A Randomized Controlled Trial of Topical Application of Tranexamic Acid in Patients with Thoracolumbar Spine Trauma Undergoing Long-Segment Instrumented Posterior Spinal Fusion

Study Design Prospective, randomized controlled trial. Purpose To evaluate the effect of topically applied tranexamic acid (TXA) on postoperative blood loss of neurologically intact patients with thoracolumbar spine trauma. Overview of Literature Few articles exist regarding the use of topical TXA for postoperative bleeding and blood transfusion in spinal surgery. Methods A total of 57 patients were operated on with long-segment instrumented fusion without decompression. In 29 patients, a solution containing 1 g of TXA (20 mL) was applied to the site of surgery via a drain tube after the spinal fascia was closed, and then the drain was clamped for 2 hours. The 28 patients in the control group received the same volume of normal saline, and clamping was performed using the same technique. The groups were compared for postoperative packed red cells (PRC) transfusion rate and drainage volume. Results The rate of postoperative PRC transfusion was significantly lower in the topical TXA group than in the control group (13.8% vs. 39.3%; relative risk, 0.35; 95% confidence interval, 0.13 to 0.97; p=0.03). The mean total drainage volume was significantly lower in the topical TXA group than in the control group (246.7±125 mL vs. 445.7±211.1 mL, p<0.01). No adverse events or complications were recorded in any patient during treatment over a mean follow-up period of 27.5 months. Conclusions The use of topically administered 1 g TXA in thoracic and lumbar spinal trauma cases effectively decreased postoperative transfusion requirements and minimized postoperative blood loss, as determined by the total drainage volume

Low-Level Tritium Measurement in Tap Water in Bangkok Area and Annual Dose Estimation

Monitoring of tritium concentration in tap water is an essential tool to determine the effective dose received from tap water. Liquid scintillation counting (LSC) is a widely used technique for determining tritium in water. Due to the very low activity of tritium in tap water, its detection requires a high-efficiency LSC with the lowest minimum detectable activity (MDA). Low-level tritium analysis in tap water were performed in two LSC models using conventional distillation techniques. The optimal conditions with the lowest MDAs were applied to determine the tritium concentration in the tap water distributed from two main sources located in the Bangkok metropolitan region: Bang Khen and Maha Sawat water treatment plants (WTPs). Twenty-six tap water samples were collected from petrol stations located around both water treatment plants. The results revealed that the amount of tritium in the tap water around the Bangkhen WTP was between 1.88-2.63 Bq/L with an average of 2.28±0.28 Bq/L, whereas those from the Maha Sawat WTP were between 2.01-2.69 Bq/L with an average of 2.44±0.26 Bq/L, which are far below the World Health Organization’s (WHO) guideline limit (10,000 Bq/L) for drinking water. The annual effective dose (AED) for infants, children and adults obtained from tap water samples around the Bangkhen WTP were 0.010, 0.014, and 0.030 µSv/year, respectively, and those from the Maha Sawat WTP were 0.011, 0.015, and 0.032 µSv/year, respectively, which are far below the WHO’s guideline limit (100 µSv/year)

Effect of occupational exposure to cytostatics and nucleotide excision repair polymorphism on chromosomal aberrations frequency

Authors evaluated the incidence of total chromosomal aberrations (CA) and their types – chromatid-type (CTA) and chromosome-type (CSA) in peripheral blood lymphocytes from 72 oncologic unit's workers occupationally exposed to cytostatics in relationship to polymorphisms of DNA repair genes XPD, XPG and XPC. The cytogenetic analysis was used for determination of chromosomal aberrations frequency and PCR-RFLP method for polymorphisms of genes. Statistically higher frequency of total CA was detected in exposed group as compared to control (1.90±1.34% vs. 1.26±0.93%; Mann-Whitney U-test, p=0.001). There was not detected any difference between CTA and CSA (0.92±1.04% vs. 0.98±1.17%). Similarly, in genes XPD exon 23 and XPC exon 15 wasn't detected any difference neither in total chromosomal aberrations nor in CTA and CSA types. Statistically significant decrease of total chromosomal aberrations and CTA-type with presence of variant allele C was detected in gene XPG exon 15. Authors pointed out the importance of individual susceptibility factors in evaluation of effects of genotoxic agents, in that event, when the concentration does not meet the occupational exposure limit