Evaluation of Area under the Constant Shape Bi-Weibull ROC Curve

The Receiver Operating Characteristic (ROC) curve generated based on assuming a constant shape Bi-Weibull distribution is studied. In the context of ROC curve analysis, it is assumed that biomarker values from controls and cases follow some specific distribution and the accuracy is evaluated by using the ROC model developed from that specified distribution. This article assumes that the biomarker values from the two groups follow Weibull distributions with equal shape parameter and different scale parameters. The ROC model, area under the ROC curve (AUC), asymptotic and bootstrap confidence intervals for the AUC are derived. Theoretical results are validated by simulation studies

On seeing a bull’s skull in a bicycle seat: innovative archaisms

This How may indigenous practices from Oceania open up the possibility of a future occluded by the long epoch of surplus accumulation? This future is not unforeseeable, but rather one that co-exists as an impeded possibility in the present. The global South—whether as time, space, value or figure—inhabits the order of the non-synchronous and archaic vis-à- vis the global north as dictated by the normative law of surplus accumulation. In this paper I draw on Theodor Adorno’s insight concerning the co-presence of the archaic in the time of modernity to argue that the perspectival aspect of modernity is built on the act of looking at something while looking through it. In other words, seeing concerns the paradoxical act of not-seeing, of looking through some aspect or dimension of whatever one is looking at. If, however, silence were to discover speech, and we commenced to look at what we have been taught to look through, modernity starts to take on an altogether different aspect. The Global South of Oceania, in particular, turns into a region of innovative archaisms, counter-national imaginings, surplus subverting practices and communal forms of ecological ethics. This paper contends that archaic indigenous practices, in concert with scientific knowledge, may be in advance of the modern in offering a pragmatic response to the climate-related crisis generated by modernity

Structural identification of two differently coordinated heptamolybdate ligands in a hexamagnesium compound

517-525Dissolution of freshly prepared molybdenum trioxide in hot aqueous magnesium carbonate followed by crystallization results in the formation of an all-inorganic heptamolybdate compound viz. [Mg(H2O)6]3[Mg(H2O)5(Mo7O24)][(H2O)5Mg (µ2-Mo7O24)Mg(H2O)5]∙6H2O (1). The crystal structure, spectral characteristics, thermal and electrochemical properties of 1 are reported. Compound 1, which crystallizes in the acentric polar space group Cc, contains six unique Mg(II) ions. The two crystallographically independent heptamolybdate anions function as a monodentate (η1) and µ2-bridging bidentate ligand, respectively, forming the anionic [Mg(H2O)5(Mo7O24)]4− and [(H2O)5Mg(µ2-Mo7O24)Mg(H2O)5]2− species, which are charge balanced by three unique hexaaquamagnesium(II) cations. The electrochemical and conductivity studies of 1 reveal the presence of [Mg(H2O)6]2+ cations and uncoordinated (Mo7O24)6− anions in solution. Thermal decomposition of 1 leads to the formation of Mg2Mo3O11 via Mg6Mo14O48 and 3Mg2Mo3O11∙5MoO3

Convenient synthesis and Raman spectral characterization of diammonium monomolybdate(VI)

1760-1767A convenient and cost-effective method is reported for the preparation of gram quantities of an ammonium-rich Mo compound viz. diammonium monomolybdate(VI) (NH4)2MoO4 (1). The process involves a thorough grinding of a commercial sample of ammonium heptamolybdate tetrahydrate (NH4)6[Mo7O24]·4H2O with an excess of ammonium bicarbonate followed by thermal treatment. The facile formation of (1) is confirmed by its characteristic Raman spectrum. The use of Raman spectroscopy to distinguish between tetrahedral monomolybdate(VI) and heptamolybdate, dichromate and monochromate(VI), paratungstate and monotungstate(VI) as well as the identification of the species present in ammoniacal solutions of MO3 (M = Cr, Mo, W) are reported

Synthesis, spectral and structural characterization of organic ammonium paratungstates

185-195Dissolution of tungsten(VI) oxide hydrate (WO3·H2O) in aqueous organic amine (RNH2 where R = methyl or ethyl, or n-propyl or isopropyl or n-butyl or t-butyl etc.) results in the formation of the tetrahedral tetraoxidotungstate(VI) species in solution. Slow evaporation of the reaction mixture to isolate the tetraoxidotungstates charge balanced by organic ammonium cations afforded organic ammonium paratungstates having formula (RNH3)10[H2W12O42]·xH2O. The presence of (WO4)2- species in solution and the [H2W12O42]10- unit in the solid product is confirmed by the characteristic Raman spectra. In this paper, we report on the synthesis, Raman spectra, crystal structures and properties of two organic ammonium paratungstates viz. (MeNH3)10[H2W12O42]·12H2O 1 (MeNH2 = methylamine) and (EtNH3)10[H2W12O42]·4H2O 2 (EtNH2 = ethylamine). Thermal decomposition of 1 or 2 at 800 °C results in the formation of monoclinic form of tungsten trioxide WO3. A comparative study of several paratungstates is described

Convenient synthesis and Raman spectral characterization of diammonium monomolybdate(VI)

A convenient and cost-effective method is reported for the preparation of gram quantities of an ammonium-rich Mo compound viz. diammonium monomolybdate(VI) (NH4)2MoO4 (1). The process involves a thorough grinding of a commercial sample of ammonium heptamolybdate tetrahydrate (NH4)6[Mo7O24]·4H2O with an excess of ammonium bicarbonate followed by thermal treatment. The facile formation of (1) is confirmed by its characteristic Raman spectrum. The use of Raman spectroscopy to distinguish between tetrahedral monomolybdate(VI) and heptamolybdate, dichromate and monochromate(VI), paratungstate and monotungstate(VI) as well as the identification of the species present in ammoniacal solutions of MO3 (M = Cr, Mo, W) are reported

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.

Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Problematically, potentiated MD variants can exhibit off-target toxicity. Here, we mine disaggregase sequence space to safely enhance Hsp104 activity via single mutations in nucleotide-binding domain 1 (NBD1) or NBD2. Like MD variants, NBD variants counter TDP-43, FUS, and α-synuclein toxicity and exhibit elevated ATPase and disaggregase activity. Unlike MD variants, non-toxic NBD1 and NBD2 variants emerge that rescue TDP-43, FUS, and α-synuclein toxicity. Potentiating substitutions alter NBD1 residues that contact ATP, ATP-binding residues, or the MD. Mutating the NBD2 protomer interface can also safely ameliorate Hsp104. Thus, we disambiguate allosteric regulation of Hsp104 by several tunable structural contacts, which can be engineered to spawn enhanced therapeutic disaggregases with minimal off-target toxicity