Assessment of 8-hydroxydeoxyguanosine levels in patients with preeclampsia: A prospective study

WOS: 000396801700013PubMed ID: 29746027Purpose of investigation: To determine the levels of 8-hydroxydeoxyguanosine (8-OHdG) in preeclampsia (PE) using (enzyme linked immunosorbent assay (ELISA) method. Materials and Methods: Twenty-two pregnant women with severe PE, 18 pregnant women with mild PE, and 40 healthy pregnant women, all between 25 and 41 weeks of gestation, were enrolled in this prospective controlled study. 8-OHdG levels in maternal serum were measured using ELISA method. Results: The authors observed no statistically significant difference in 8-OHdG levels between the mild-severe PE and control groups (p = 0.208). Conclusion: The present results do not support the concept that 8-OHdG has a role in the etiopathogenesis of PE.Gaziantep University [TF. 13. 25]This study was granted by the project research unit of Gaziantep University (project number TF. 13. 25)

The associtation between aberrant right subclavian artery and trisomy 21 in a tertiary center in Turkey

Objectives: We hoped to reveal the frequency of Aberrant Right Subclavian Artery (ARSA) and to find the relationship of isolated/non-isolated ARSA with chromosomal defects and other fetal congenital heart diseases (FCHD) in a heterogeneous population. Material and methods: This was a retrospective cohort study conducted between December 2015 to September 2018. Women admitted for routine ultrasound examination or referred to our hospital for a suspected fetal anomaly were underwent detailed fetal anomaly ultrasonography scan and tested for the presence of ARSA. Results: ARSA was detected in 27 patients and an isolated finding in 13 (48%) cases. Among 13 cases with isolated ARSA, trisomy 21 was diagnosed in 1 case. In the non-isolated group (n: 14, 52%), five cases presented with trisomy 21. There was no significant difference of trisomy 21 frequency between isolated and non-isolated groups (7.6% vs 35.7%, p = 0.08). In 3 patients, FCHD was diagnosed and 2 of them had trisomy 21. Conclusions: Our study shows that ARSA can be the only marker in trisomy 21. The examination of the subclavian artery must be a part of the fetal anomaly ultrasonography. Detecting an ARSA should increase the attentiveness of the sonographer to investigate for the other markers of trisomy 21. In the existence of other findings, invasive diagnostic procedures should be offered to the patients, whereas in cases that arsa is the only finding, other risk factors should be investigated to offer karyotyping or cell-free DNA analysis

Placenta accreta spectrum surgery with the Joel Cohen incision for abdominal access: a single-center experience

Objectives: Placenta accreta spectrum (PAS) is usually treated by hysterectomy performed through a midline incision. We hypothesize that PAS surgery can be performed through a Joel-Cohen incision with adequate sight and safety. Material and methods: The data on women having a hysterectomy due to PAS between 2013–2021 was collected retrospectively. Operation length, baby’s pre-delivery general anesthesia exposure time, transfusion rates, complication rates, postoperative admission to the intensive care unit (ICU), postoperative hospital stay, and neonatal outcomes were collected. In addition, the data investigated whether the operation was performed under emergent conditions and in the early (2013–2016) or late (2017–2021) years. Results: 161 patients met the inclusion criteria. The median gestational age at delivery was 34 weeks (27–39). The mean operation length was 150 minutes (75–420), and the anesthesia–to–delivery interval was 32 minutes (5–95). Twenty-three (14%) patients did not receive any blood product, 73 (45%) received less than three packs of erythrocyte, and only seven (4%) had a massive transfusion. Bladder injuries occurred in 24 (15%). Preoperative anemia, hypogastric artery ligation, transfusion, ICU admission, and maternal and neonatal complications were more frequent in emergent cases. Comparison between the early and late groups showed a decrease in the rate of anemia, maternal ICU admission, hypogastric artery ligation, and neonatal complications. In addition, infectious complications were relatively rare in all groups. Conclusions: The Joel-Cohen incision and bladder dissection before the baby's delivery reduce transfusion rates and avoid midline incision, which is prone to complications and unpleasant cosmetic appearance while performing a hysterectomy for PAS surgery

Clinicopathologic characteristics and prognosis comparison of the uterine high grade endometrial carcinomas

Objectives: Grade 3 endometrioid adenocarcinomas (G3 EAC), type two endometrial carcinomas (Type 2 EC), and alsouterine carcinosarcomas (UCS) are considered as high-grade endometrial adenocarcinomas. The aim of this study was tocompare the clinicopathologic features and survival of patients with UCS, G3 EAC, Type2 EC.Material and methods: We included two hundred and thirty-five patients in this study. Patients were divided into threegroups according to the type of tumor as uterine G3 EAC (group 1, n = 62), Type 2 EC (serous, clear and mixed types; group 2,n = 93), and UCS (group 3, n = 80). We compared the groups according to age, initial symptom, surgical approach, stage,myometrial invasion (MI), lymph node invasion (LNI), lymphovascular space invasion (LVSI), adjuvant therapy, and survival.When comparing the survival outcomes the Kaplan-Meier analysis was performed.Results: The groups were similar according to age, menopausal status, nulliparity, initial symptoms, stage, LVSI, and LNI.Positive cytology was determined significantly more in group 3. There was a significant difference between the groups interms of myometrial invasion degree. Optimal cytoreduction was similar among the groups. The primary adjuvant treatmentwas chemotherapy for UCS and Type2 EAC whereas radiotherapy was the main adjuvant treatment for G3 EAC. Therewere no significant differences among the groups according to overall survival (OS) (p = 0.290).Conclusions: Although the survival difference among the groups can not be revealed, these patients have different clinicaland pathological features and they should be considered as different groups

Perinatal outcomes of the antenatally diagnosed omphalocele cases: a single tertiary center experience

Objectives: To evaluate the perinatal outcomes of antenatally diagnosed omphalocele cases. Material and methods: This was a retrospective study conducted between July 2014 and February 2020 at the prenatal diagnosis center of a university clinic. Gestational week of diagnosis, associated anomalies, karyotype analysis results, complications during pregnancy, termination/delivery characteristics, and postnatal results were evaluated. Results: The analysis was performed on 58 patients. The median diagnosis time was 14.5 weeks of gestation. Thirty-three cases (57%) were defined in the first trimester. 33 (57%) of 58 patients had one or more concomitant anomalies, while 25 patients (43%) had isolated omphalocele. The most common associated anomaly was a cardiac anomaly which was observed in 17 fetuses (30% of all omphalocele cases). Karyotype analysis was performed in forty-five patients (41 in the prenatal period, 4 in the postnatal period). A normal karyotype was detected in 27 cases (60%). Trisomy 18 was the most common chromosomal anomaly (n = 15, 33.3%). Thirty of 58 patients (52%) requested termination of pregnancy (TOP) in the early pregnancy period. Thirteen of the cases died in-utero (22%). Fifteen pregnancies resulted in live births (26%), of those eight were lost in the first year of life (six of them had additional anomalies, while two of them had isolated omphalocele but the omphalocele pouch was containing the liver in those two babies). Conclusions: Most of the cases with an omphalocele can be diagnosed in the first trimester. Cardiac anomalies were the most common associated anomalies, while trisomy 18 is the most common chromosomal anomaly. Thus, earlier and effective counseling can be made about the prognosis of pregnancy

Gebelikte bulantı kusması olan kadınların hastaneye yatış endikasyonunun belirlenmesinde puqe (pregnancy-uniqe quantification of emesıs and nausea) skorlaması ile fizik muayene bulguları ve laboratuar sonuçlarının karşılaştırılması

TEZ7356Tez (Uzmanlık) -- Çukurova Üniversitesi, Adana, 2009.Kaynakça (s.52-57) var.viii, 58 s. ; 29 cm.Aim: We have aimed to compare PUQE scoring with physical examination and laboratory findings in determining the indications of hospitalization for pregnant women suffering from nausea and vomiting and be able to decide hospitalization in a short and practical way without using physical examination and laboratory findings while determining the hospitalization indications. Materials and Methods: The study was conducted from the 1st of July 2008 to 28th of February 2009 by evaluating the women who had singleton viable pregnancy less than 14 weeks of gestation with nausea and vomiting and who admitted to our institution. PUQE query was applied with the clinical and laboratory assessment. Women who treated in the hospital or not were compared in point of view of the PUQE score and the body mass index (BMI). Student-t test and ki-square tests were used for evaluation of the differences between the groups...Amaç: Bulantı kusması olan gebelerin hastaneye yatış endikasyonunu belirlemede kısa ve basit bir skorlama sistemi olan, PUQE skorlama sistemi ile laboratuar ve fizik muayene bulgularını karşılaştırmayı ve yatış endikasyonunu belirlerken fizik muayene ve laboratuar sonuçlarına ihtiyaç duymadan, kısa ve pratik bir şekilde yatışa karar verebilmeyi hedefledik. Gereç ve Yöntem: Çalışmaya 01 Temmuz 2008 ile 28 Şubat 2009 tarihleri arasında hastanemize başvuran, bulantı-kusma yakınması olan, ?14 hafta'lık, canlı, tekil gebelikler dahil edildi. Hastaların klinik ve laboratuar değerlendirmesinin yanı sıra PUQE puanlama sistemi için anket de uygulandı. Hastaneye yatış ihtiyacı olduğu düşünülen ya da ayaktan tedaviye alınan gebeler PUQE puanı ve vücut kütle indeksi açısından değerlendirildi. Gruplar arası farklılıklar student-t testi veya ki-kare testi kullanılarak değerlendirildi...Bu çalışma Ç.Ü. Bilimsel Araştırma Projeleri Birimi Tarafından Desteklenmiştir. Proje No:TF2008LTP3

Women's Consumption of Probiotic Food; The Example of Yogurt and Kefir

WOS: 000473218600007Objective: This study examined the relationship between pregnancy, women's knowledge level, and consumption of probiotic foods. Methods: This descriptive and cross-sectional study was carried out with the participation of 560 pregnant (n:280) and non-pregnant (n:280) women who applied to the Gynecology and Obstetrics polyclinic at a university hospital between June and August 2017. Data were collected using a data collection form developed by the researchers based on relevant scholarly literature. Results: The two groups (pregnant and non-pregnant women) were similar in average age and educational level. Of the participants, 59.1% knew the term probiotics. The rates of knowing the term probiotics (p: 0.001), recognizing kefir as a type of probiotic food, and consuming kefir as a probiotic food (p: 0.001) were higher in non-pregnant women than in pregnant women at a statistically significant level (p<0.01). Women consumed probiotic foods mostly for problems in the digestive system (87%) and strengthening the immune system (74.1%). Not knowing what probiotic meant was the most common reason (22%) for not consuming probiotic foods. Discussion: Of the participants, 59.1% knew the term probiotics. Non-pregnant women's rate of knowing the term probiotics (67.9%) was statistically higher than that of the pregnant women (50.4%) (p: 0.001; p<0.01). In sum, some pregnant women did not know the term probiotics. In the scholarly literature, there are no studies on pregnant women's consumption and knowledge level of probiotic foods. Most of the studies' sample groups were students. Findings of all these studies show that the most significant reason for not consuming probiotic foods was not having the sufficient knowledge about probiotics. Considering the positive effects of probiotic foods on health, increasing the consumption of probiotics could contribute to a healthy pregnancy. In Turkey, we need to determine pregnant women's knowledge of probiotic foods to initiate and popularize the consumption of probiotics. Conclusion: Findings of this study indicated that pregnant women did not have sufficient knowledge of the term probiotics. Pregnancy is the ideal period for women to develop behavior that protects and improve both their own and their babies' health. For this reason, raising awareness on and motivating pregnant women toward probiotic food consumption are significant

Thrombocytopenia in Pregnancy

Trombositopeni gebeliklerin %7-10'unda saptanan, trombosit sayısının düşüklüğüyle karakterize bir durumdur. Gebelikte görülen trombositopenin en sık sebebi gestasyonel trombositopenidir. Bu hastalarda trombositopeni genelde hafif olduğundan semptom görülmez. Tanı çoğunlukla bağ dokusu hastalıklarının,ilaç etkilerinin, obstetriyle ilişkili sebeplerin dışlanmasıyla konulur. Erken gebelik haftalarında görülen trombositopenin etyolojisinde en fazla otoimmun sebepler rol alır. Preeklampsi,HELLP sendromu gibi obstetriyle ilişkili nedenlere ikincil gelişen trombositopeniler ise her zaman akılda tutulmalıdır. Bu durumların varlığında çoğu zaman doğum gerçekleşmeden trombositopeni düzelmeyecektir. Klinisyen; tedavi gerektirmeyen trombositopenilerle, annenin fetusun hayatını tehdit eden ve bu nedenle acil ve ciddi bakım gerektiren trombositopeni sebepleri arasında ayırımı iyi yapabilmelidir.Thrombocytopenia, which is encountered in 7-10% of pregnancies is characterized with decreased number of thrombocytes. The most frequent cause of thrombocytopenia during pregnancy is gestational thrombocytopenia. These patients usually do not have symptoms due to mild thrombocytopenia. The diagnosis is usually established by excluding connective tissue disorders, drug effects and obstetric causes. The etiology of thrombocytopenia during early pregnancy is most frequently due to autoimmune causes. Thrombocytopenia secondary to obstetric causes like preeclampsia, HELLP syndrome should always be kept in mind. Under these circumstances the thrombocytopenia will not resolve unless pregnancy is terminated. The clinician should be able to distinguish between thrombocytopenia that does not require treatment and the causes that require emergent and serious medical interventions

Pregnancy and Toxoplasma Infection

Toxoplasmosis is an infectious disease caused by a protozoa named Toxoplasma gondii. It is a very important disease because it is related to fetal anomalies and poor perinatal outcomes like abortus and stillbirth. It spreads via uncooked meat and contaminated food. Timely and appropriate treatment and management of this infection prenatally reduces the risk of serious neurological sequelae. Therefore it is crucial that clinician who takes care of pregnant women know this infection deeply. In this review we aimed to summarize the prenatal diagnosis, complications and treatment of toxoplasma infection. [Archives Medical Review Journal 2016; 25(4.000): 457-466