Studies in Chronopotentiometric Behaviour of Nitrobenzene

479-48

Polarographic & Coulometric Behaviour of Aromatic Nitro Compounds: Part IV-Nitrobenzene in Acetonitrile

24-2

Throughput Optimization in High Speed Downlink Packet Access (HSDPA)

In this paper, we investigate throughput optimization in High Speed Downlink Packet Access (HSDPA). Specifically, we propose offline and online algorithms for adjusting the Channel Quality Indicator (CQI) used by the network to schedule data transmission. In the offline algorithm, a given target BLER is achieved by adjusting CQI based on ACK/NAK history. By sweeping through different target BLERs, we can find the throughput optimal BLER offline. This algorithm could be used not only to optimize throughput but also to enable fair resource allocation among mobile users in HSDPA. In the online algorithm, the CQI offset is adapted using an estimated short term throughput gradient without specifying a target BLER. An adaptive stepsize mechanism is proposed to track temporal variation of the environment. We investigate convergence behavior of both algorithms. Simulation results show that the proposed offline algorithm can achieve the given target BLER with good accuracy. Both algorithms yield up to 30% HSDPA throughput improvement over that with 10% target BLER

ETHNO-MEDICO-BOTANY OF MOODABIDRI RANGE WITH REFERENCE TO RESPIRATORY DISORDERS

The study of Indian medicinal plants was first started in the early part of 20th century. The rarely available plants or drugs can be included in their day to day practice. The traditional system of medicine is very effective in many ailments, one among them is common respiratory diseases. Considering these factors, an ethno-medico-botanical survey of Moodabidri range of Dakshina Kanada district of Karnataka state was carried out. Twenty six villages in and around Moodabdiri were identified and planned for the present study. The team local members visited each village to gather information regarding folklore practitioners and medicinal plants. A detailed proforma was prepared containing information about folklore practitioners and regarding the medicinal plants. Information thus gathered were verified and crosschecked by making use of available classical and current literature such as Bhavaprakasha Nighantu, Raja Nighantu, Flora of Udupi, Flora of South Canara, Flora of Shimog Flora of Madras presidency, Flora of British India and also by consulting expert herbalists. About 28 plants belonging to 17 families are used as herbal remedies in respiratory disorders which was observed during the survey are listed. Local communities not only use these plants in different respiratory ailments, apart from this it was observed that they take good care for their conservation and protection

Self-Care Behaviours and Glycemic Control among Adults with Type 2 Diabetes

Aim: To explore self-care behaviours and glycemic control among adults with type 2 diabetes. Design: A descriptive cross-sectional design was used for the study. Methods: The revised summary of diabetes mellitus questionnaire was used to collect data and glycated haemaglobin. A random sample comprising of 350 Omani adults with type 2 diabetes were selected between January-June 2010. Structural equation modelling and ANOVA were used for analysis. Results/Findings: One-third of the adults with type 2 diabetes followed diet, foot care and medications (on an average of 3 days/7 days) compared to half percentage of them adhering to foot care. 27% of the total variance in self-car activities was accounted by diet, 32% by exercise and 17% by medications. Blood glucose monitoring, foot care, and smoking and HbA1c accounted for 60%, 78%, and 51% variances. The standardized path coefficients of diet, exercise, smoking, foot care, blood sugar monitoring and medications had a significantly positive influence on self-care behaviours. Conclusion: There were inadequate self-care behaviours among the majority of adults with type 2 diabetes with poor glycaemic control. Nurses should use the self-care management model when designing tailored educational interventions to enhance glycemic control

Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies

A series of newer previously synthesized fluorinated chalcones and their 2-amino-pyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives were screened for their in vitro antitubercular activity and in silico methods. Compound 40 (MIC~ 8 μM) was the most potent among all 60 compounds, whose potency is comparable with broad spectrum antibiotics like ciprofloxacin and streptomycin and three times more potent than pyrazinamide. Additionally, compound 40 was also less selective and hence non-toxic towards the human live cell lines-LO2 in its MTT assay. Compounds 30, 27, 50, 41, 51, and 60 have exhibited streptomycin like activity (MIC~16–18 μM). Fluorinated chalcones, pyridine and pyran derivatives were found to occupy prime position in thymidylate kinase enzymatic pockets in molecular docking studies. The molecule 40 being most potent had shown a binding energy of -9.67 Kcal/mol, while docking against thymidylate kinase, which was compared with its in vitro MIC value (~8 μM). These findings suggest that 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives are prospective lead molecules for the development of novel antitubercular drugs