La Tierra y el Universo: Evolución de las ideas del alumnado tras el proceso de enseñanza-aprendizaje

El presente Trabajo de Fin de Grado está basado en la investigación de las ideas y concepciones científicas del alumnado de Educación Primaria en lo referente al ámbito de estudio de la Tierra y el Universo, más concretamente lo relativo al Sistema Solar y a la relación del Sistema Tierra-Sol-Luna. Para llevar a cabo dicha investigación se han utilizado como instrumento tres cuestionarios adaptados según el curso destinatario de los mismos, los cuales han sido rellenados por una muestra de 80 alumnos de segundo, cuarto y sexto de Primaria de un centro educativo. Las preguntas de los cuestionarios son de tipo abierto para no limitar al alumnado a responder de forma cerrada y así obtener más información de sus ideas y concepciones. Con los resultados obtenidos se ha llevado a cabo un análisis cualitativo de las concepciones del alumnado y, para finalizar, se han expuesto las conclusiones surgidas tras la investigación.Universidad de Sevilla. Grado en Educación Primari

Randomized Phase II Trial of Sapanisertib ± TAK-117 vs. Everolimus in Patients With Advanced Renal Cell Carcinoma After VEGF-Targeted Therapy

MTOR inhibitors; Everolimus; Renal cell carcinomaInhibidores de MTOR; Everolimus; Carcinoma de células renalesInhibidors de MTOR; Everolimus; Carcinoma de cèl·lules renalsBackground Sapanisertib, a dual mTORC1/2 inhibitor, may offer more complete inhibition of the PI3K/AKT/mTOR pathway than mTORC1 inhibitors, such as everolimus. This phase II study evaluated the efficacy and safety of single-agent sapanisertib and sapanisertib plus the PI3Kα inhibitor TAK-117, vs. everolimus in patients with advanced clear cell renal cell carcinoma (ccRCC) that had progressed on or after VEGF-targeted therapy. Materials and Methods Patients with histologically confirmed, advanced ccRCC were randomized 1:1:1 to receive single-agent everolimus 10 mg once daily, single-agent sapanisertib 30 mg once weekly, or sapanisertib 4 mg plus TAK-117 200 mg, both once daily for 3 days/week, in 28-day cycles. The primary endpoint was progression-free survival (PFS). Results Ninety-five patients were treated with everolimus or sapanisertib (n = 32 each), or sapanisertib plus TAK-117 (n = 31). There were no significant differences in PFS among the 3 groups or across any subgroups. Median PFS was 3.8 months with everolimus vs. 3.6 months with sapanisertib (HR, 1.33; 95% CI, 0.75-2.36), and 3.1 months with sapanisertib plus TAK-117 (HR, 1.37; 95% CI, 0.75-2.52). No significant differences in overall survival were seen among groups. Overall response rate was 16.7%, 0%, and 7.1%, respectively. Discontinuations due to treatment-emergent adverse events were 15.6%, 28.1%, and 29.0%. Conclusion Sapanisertib with or without TAK-117 was less tolerable and did not improve efficacy vs. everolimus in patients with advanced ccRCC who had relapsed after or were refractory to VEGF-targeted therapies. Dual mTORC1/2 inhibition may not be an effective therapeutic approach for these patients.This article is supported by Takeda Development Center Americas, Inc., Lexington, MA, USA

Empresa Autopartes Colombia

Nota: Las actividades se encuentran en el documento adjuntoNota: Este documento está sujeto a la Advertencia legal y condiciones de uso sobre las bases de datos de objetos de aprendizaje.La Junta Directiva de una compañía del sector metalmecánico dedicada a la fabricación de autopartes, se encontraba en una situación difícil debido a que se estaban tomando decisiones muy conservadoras con respecto a la innovación tanto administrativa como tecnológica para enfrentar el mundo global competitivo, en el cual la organización estaba operando. En varias ocasiones intentaron motivar a los demás miembros de la Junta Directiva para inducir rápidos cambios que llevaran a la organización a ser más competitiva, sin embargo, no encontraron respuesta positiva.Universidad EAN. Vicerrectoría de Investigacione

Pixel-Based Image Processing for CIE Standard Sky Classification through ANN

Digital sky images are studied for the definition of sky conditions in accordance with the CIE Standard General Sky Guide. Likewise, adequate image-processing methods are analyzed that highlight key image information, prior to the application of Artificial Neural Network classification algorithms. Twenty-two image-processing methods are reviewed and applied to a broad and unbiased dataset of 1500 sky images recorded in Burgos, Spain, over an extensive experimental campaign. The dataset comprises one hundred images of each CIE standard sky type, previously classified from simultaneous sky scanner data. Color spaces, spectral features, and texture filters image-processing methods are applied. While the use of the traditional RGB color space for image-processing yielded good results (ANN accuracy equal to 86.6%), other color spaces, such as Hue Saturation Value (HSV), which may be more appropriate, increased the accuracy of their global classifications. The use of either the green or the blue monochromatic channels improved sky classification, both for the fifteen CIE standard sky types and for simpler classification into clear, partial, and overcast conditions. The main conclusion was that specific image-processing methods could improve ANN-algorithm accuracy, depending on the image information required for the classification problem.Regional Government of Castilla y León under the “Support Program for Recognized Research Groups of Public Universities of Castilla y León” (BU021G19) and the Spanish Ministry 595 of Science and Innovation under the I + D + i state program “Challenges Research Projects” (Ref. RTI2018-098900-B-I00). Diego Granados López expresses his thanks for economic support from the Junta de Castilla-León (PIRTU Program, ORDEN EDU/556/2019)