Theoretical analysis of direct CPCP violation and differential decay width in D±→π±π+π−D^\pm\to \pi^\pm \pi^+\pi^- in phase space around the resonances ρ0(770)\rho^0(770) and f0(500)f_0(500)

We perform a theoretical study on direct $CP$ violation in $D^\pm\to \pi^\pm \pi^+\pi^-$ in phase space around the intermediate states $\rho^0(770)$ and $f_0(500)$. The possible interference between the amplitudes corresponding to the two resonances is taken into account, and the relative strong phase of the two amplitudes is treated as a free parameter. Our analysis shows that by properly chosen the strong phase, both the $CP$ violation strength and differential decay width accommodate to the experimental results.Comment: 15 pages, 5 figure

MagicBrush: A Manually Annotated Dataset for Instruction-Guided Image Editing

Text-guided image editing is widely needed in daily life, ranging from personal use to professional applications such as Photoshop. However, existing methods are either zero-shot or trained on an automatically synthesized dataset, which contains a high volume of noise. Thus, they still require lots of manual tuning to produce desirable outcomes in practice. To address this issue, we introduce MagicBrush (https://osu-nlp-group.github.io/MagicBrush/), the first large-scale, manually annotated dataset for instruction-guided real image editing that covers diverse scenarios: single-turn, multi-turn, mask-provided, and mask-free editing. MagicBrush comprises over 10K manually annotated triplets (source image, instruction, target image), which supports trainining large-scale text-guided image editing models. We fine-tune InstructPix2Pix on MagicBrush and show that the new model can produce much better images according to human evaluation. We further conduct extensive experiments to evaluate current image editing baselines from multiple dimensions including quantitative, qualitative, and human evaluations. The results reveal the challenging nature of our dataset and the gap between current baselines and real-world editing needs.Comment: NeurIPS 2023; Website: https://osu-nlp-group.github.io/MagicBrush

Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production

Background: With unique physiochemical environments in subcellular organelles, there has been growing interest in harnessing yeast organelles for bioproduct synthesis. Among these organelles, the yeast mitochondrion has been found to be an attractive compartment for production of terpenoids and branched-chain alcohols, which could be credited to the abundant supply of acetyl-CoA, ATP and cofactors. In this study we explored the mitochondrial potential for production of 3-hydroxypropionate (3-HP) and performed the cofactor engineering and flux control at the acetyl-CoA node to maximize 3-HP synthesis. Results: Metabolic modeling suggested that the mitochondrion serves as a more suitable compartment for 3-HP synthesis via the malonyl-CoA pathway than the cytosol, due to the opportunity to obtain a higher maximum yield and a lower oxygen consumption. With the malonyl-CoA reductase (MCR) targeted into the mitochondria, the 3-HP production increased to 0.27\ua0g/L compared with 0.09\ua0g/L with MCR expressed in the cytosol. With enhanced expression of dissected MCR enzymes, the titer reached to 4.42\ua0g/L, comparable to the highest titer achieved in the cytosol so far. Then, the mitochondrial NADPH supply was optimized by overexpressing POS5 and IDP1, which resulted in an increase in the 3-HP titer to 5.11\ua0g/L. Furthermore, with induced expression of an ACC1 mutant in the mitochondria, the final 3-HP production reached 6.16\ua0g/L in shake flask fermentations. The constructed strain was then evaluated in fed-batch fermentations, and produced 71.09\ua0g/L 3-HP with a productivity of 0.71\ua0g/L/h and a yield on glucose of 0.23\ua0g/g. Conclusions: In this study, the yeast mitochondrion is reported as an attractive compartment for 3-HP production. The final 3-HP titer of 71.09\ua0g/L with a productivity of 0.71\ua0g/L/h was achieved in fed-batch fermentations, representing the highest titer reported for Saccharomyces cerevisiae so far, that demonstrated the potential of recruiting the yeast mitochondria for further development of cell factories

{μ-N-[(Diphenyl­phosphino)meth­yl]pyridin-2-amine-κ2 N 1:P}bis­{[2-(2,2′-bipyridin-6-yl)phenyl-κ3 N,N′,C 1]platinum(II)} bis­(perchlorate)

The title compound, [Pt2(C16H11N2)2(C18H17N2P)](ClO4)2, contains two PtII atoms, bridged by an N-[(diphenyl­phosphino)meth­yl]pyridin-2-amine (dppmp) ligand. One Pt atom is coordinated by one P atom from the dppmp ligand, and one C atom and two N atoms from a 6-phenyl-2,2′-bipyridine (pbpy) ligand in a square-planar geometry. The other Pt atom is coordinated by one N atom from the dppmp ligand, and one C atom and two N atoms from another pbpy ligand in a square-planar geometry. There are intra­molecular π–π inter­actions between the pbpy ligands, with a centroid–centroid distance of 3.62 (1) Å between two pyridyl rings. The oxygen atoms of both perchlorate anions are disordered, each over two different positions [occupanicies 0.49 (3)/0.51 (3) and 0.48 (2)/0.52 (2)]

Metallic surface states in a correlated d-electron topological Kondo insulator candidate FeSb2

The resistance of a conventional insulator diverges as temperature approaches zero. The peculiar low temperature resistivity saturation in the 4f Kondo insulator (KI) SmB6 has spurred proposals of a correlation-driven topological Kondo insulator (TKI) with exotic ground states. However, the scarcity of model TKI material families leaves difficulties in disentangling key ingredients from irrelevant details. Here we use angle-resolved photoemission spectroscopy (ARPES) to study FeSb2, a correlated d-electron KI candidate that also exhibits a low temperature resistivity saturation. On the (010) surface, we find a rich assemblage of metallic states with two-dimensional dispersion. Measurements of the bulk band structure reveal band renormalization, a large temperature-dependent band shift, and flat spectral features along certain high symmetry directions, providing spectroscopic evidence for strong correlations. Our observations suggest that exotic insulating states resembling those in SmB6 and YbB12 may also exist in systems with d instead of f electrons