Relative Entropy in CFT

By using Araki's relative entropy, Lieb's convexity and the theory of singular integrals, we compute the mutual information associated with free fermions, and we deduce many results about entropies for chiral CFT's which are embedded into free fermions, and their extensions. Such relative entropies in CFT are here computed explicitly for the first time in a mathematical rigorous way. Our results agree with previous computations by physicists based on heuristic arguments; in addition we uncover a surprising connection with the theory of subfactors, in particular by showing that a certain duality, which is argued to be true on physical grounds, is in fact violated if the global dimension of the conformal net is greater than $1.$Comment: 31 page

The correlation between the expression of differentiated embryo-chondrocyte expressed gene l and oral squamous cell carcinoma

BACKGROUND: This study aims to explore the correlation between expression of differentiated embryo-chondrocyte expressed gene l (DEC1) and oral squamous cell carcinoma (OSCC), which could provide the reference for treatment and prognosis assessment of OSCC. METHODS: The expression of DEC1 in tissues from 56 primary OSCC patients and 20 normal oral mucosa samples were detected using real-time polymerase chain reaction and immunohistochemical methods, respectively. RESULTS: The results showed that the positive expression rate of DEC1 in the OSCC group was significantly higher than that in the normal group (P <0.05); further, the expression of DEC1 in different OSCC groups was statistically significant (P <0.05). The expression of DEC1 in the 1-year recurrence OSCC group was significantly higher than other groups. The expression of DEC1 in the 3-years no recurrence OSCC group was the lowest. CONCLUSIONS: The expression of DEC1 was associated with the incidence of OSCC and there was a negative correlation between the expression of DEC1 and the prognosis of OSCC

Tie-dye technique and pattern features

Relationship between tie-dye technique and image pattern has been studied. Based on digital image processing, average value of HSV (hue, saturation, value) tri-component of valid tie-dye area, proportion of incompletely dyed area in HSV color space and the Tamura first three texture features of digital tie-dye image have been extracted. Then, the repeated tests and analysis of variance (ANOVA) of rotation speed and concentration have been done. The results show the obvious impact of concentration and rotation speed on the color and texture feature of tie-dye pattern. Furthermore, back propagation neutral network is developed and partial pattern features with low correlation is used to forecast the tie-dye concentration and rotation speed. The experiment results show the 100% rate of forecast, which proves that pattern features can effectively achieve the technique forecast

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosomelocalized protein kinase that acts as a critical regulator of cellular growth, is believed to mediate most Rap actions. Here, we identified mucolipin 1 (transient receptor potential channel mucolipin 1 [TRPML1], also known as MCOLN1), the principle Ca2+ release channel in the lysosome, as another direct target of Rap. Patch-clamping of isolated lysosomal membranes showed that micromolar concentrations of Rap and some rapalogs activated lysosomal TRPML1 directly and specifically. Pharmacological inhibition or genetic inactivation of mTOR failed to mimic the Rap effect. In vitro binding assays revealed that Rap bound directly to purified TRPML1 proteins with a micromolar affinity. In both healthy and disease human fibroblasts, Rap and rapalogs induced autophagic flux via nuclear translocation of transcription factor EB (TFEB). However, such effects were abolished in TRPML1-deficient cells or by TRPML1 inhibitors. Hence, Rap and rapalogs promote autophagy via a TRPML1-dependent mechanism. Given the demonstrated roles of TRPML1 and TFEB in cellular clearance, we propose that lysosomal TRPML1 may contribute a significant portion to the in vivo neuroprotective and anti-aging effects of Rap via an augmentation of autophagy and lysosomal biogenesis

Effects of replacing dietary fishmeal with zymolytic black soldier fly larvae on the growth performance of the mud crab (<em>scylla paramamosain</em>) larvae

Black soldier fly have been shown to be one of the optimal alternatives to fishmeal, but there are few reports on the effects of zymolytic black soldier fly larvae (ZBSFL) on the growth and digestion of crustaceans. An 8-week feeding trial was conducted to evaluate the effects of different replacement levels of ZBFLS on growth performance, body composition, and digestive enzyme activity of the mud crab larvae. Four diets were formulated by replacing fishmeal with 0%, 5%, 10% and 15% ZBSFL in the basal diet. Crab larvae were randomly divided into four groups of three replicates each and fed twice daily. The results showed that the SR of crab larvae was higher than that of the no-substitution group when the substitution rate reached 5% (P < 0.05). There was no significant change in SR when the substitution rate was further increased. Weight growth rate and Specific growth rate were similar, both highest at 10% substitution ratio. The crude protein content of whole crab larvae gradually increased as the proportion of FM substituted by ZBSFL increased. The lipid content of whole crab larvae in the 5% substitution ratio group was significantly higher than that in all other groups (P < 0.05). Meanwhile. The activities of amylase, protease and lipase gradually increased. In this experiment, when the percentage of ZBSFL substitution for FM reached 10%, its growth performance was optimal, with higher SR, less negative effects and more balanced indicators in all aspects. When the substitution rate was further increased, it might increase the digestive burden of the crab and negatively affect its growth

Honghua Xiaoyao tablet combined with estradiol improves ovarian function in D-galactose-induced aging mice by reducing apoptosis and affecting the release of reproductive hormones: an in vivo study

Context: It is very necessary to delay ovarian aging and prevent age-related health problems. The active ingredient in Honghua Xiaoyao tablet (HHXYT) has the effects of anti-oxidation, anti-inflammation, immune regulation and so on.Objective: To explore the effect and mechanism of Honghua Xiaoyao tablet on aging model mice.Materials and methods: The aging model was established by intraperitoneal injection of D-galactose in model mice. The mice in the HHXYT-L,M,H group were given 0.3 g/kg, 0.6 g/kg and 1.2 g/kg Honghua Xiaoyao tablet suspension respectively, and the HHXYT-M + E2 group was given 0.6 g/kg HHXYT +0.13 mg/kg estradiol valerate for 30 days. In this study, ELISA, HE, Western blot, IH and TUNEL were used.Results: HHXYT + E2 can improve the gonadal index, estrous cycle of aging mice. In HHXYT-M + E2 group, the level of FSH and LH decreased, while E2 and AMH increased significantly. The number of growing follicles in HHXYT-M + E2 group increased, which was better than that of HHXYT alone. Western blot results showed that HHXYT-M + E2 group decreased the expression of Bax, cleaved-Parp, cleaved-Casp-3 and CytC molecules and increased the expression of Bcl-2 in ovarian tissue. FSHR expression decreased in model group and increased in HHXYT group. TUNEL staining showed that the number of apoptotic cells in HHXYT group was reduced, and the HHXYT-M + E2 group was the most significantly.Discussion and conclusion: HHXYT can improve the level of sex hormones and increase the number of growing follicles in aging mice. HHXYT-M + E2 group has the best effect, and its mechanism may be related to reducing ovarian granulosa cell apoptosis