LES and RANS for turbulent flow over arrays of wall-mounted obstacles

Large-eddy simulation (LES) has been applied to calculate the turbulent flow over staggered wall-mounted cubes and staggered random arrays of obstacles with area density 25%, at Reynolds numbers between 5 × 10^3 and 5 10^6, based on the free stream velocity and the obstacle height. Re = 5 × 10^3 data were intensively validated against direct numerical simulation (DNS) results at the same Re and experimental data obtained in a boundary layer developing over an identical roughness and at a rather higher Re. The results collectively confirm that Reynolds number dependency is very weak, principally because the surface drag is predominantly form drag and the turbulence production process is at scales comparable to the roughness element sizes. LES is thus able to simulate turbulent flow over the urban-like obstacles at high Re with grids that would be far too coarse for adequate computation of corresponding smooth-wall flows. Comparison between LES and steady Reynolds-averaged Navier-Stokes (RANS) results are included, emphasising that the latter are inadequate, especially within the canopy region

Measuring the Impact of Meat Packing and Processing Facilities in Nonmetropolitan Counties: A Difference-in-Differences Approach

Considerable controversy exists regarding the costs and benefits of growth in the meat packing and processing industry for rural counties. This study investigates the effects of this industry on social and economic outcomes in nonmetropolitan counties of 23 Midwestern and Southern states from 1990 to 2000. Results suggest that as the meat packing industry's share of a county's total employment and wage bill rises, total employment growth increases. However, employment growth in other sectors slows, as does local wage growth. Industry growth has little impact on local crime rates or on growth of government spending on education, health, or police protection. Copyright 2007, Oxford University Press.

INSIGHT MM: A large, global, prospective, non-interventional, real-world study of patients with multiple myeloma

With the introduction of new drugs with different mechanisms of action, multiple myeloma (MM) patients' outcomes have improved. However, the efficacy seen in clinical trials is often not seen in real-world settings and data on the effectiveness of MM therapies are needed. INSIGHT MM is a prospective, global, non-interventional, observational study that is enrolling approximately 4200 patients with newly diagnosed or relapsed/refractory MM, making it the largest study of its kind to date. The study aims to describe contemporary, real-world patterns of patient characteristics, clinical disease presentation, therapies chosen, clinical outcomes (response, treatment duration, time-to-next-therapy, progression-free and overall survival), safety, healthcare resource utilization and quality of life. One interim analysis has been conducted to date; current accrual is approximately 3094 patients. © 2019 Future Medicine Ltd