Abraham Fleming: writer, cleric and preacher in Elizabethan and Jacobean London

Since his death in 1607, Abraham Fleming has never been completely forgotten about. This thesis covers all aspects of Fleming’s life. It begins with his time at Cambridge and the relationships he forged there. It studies his varied and sometimes groundbreaking contributions to the books associated with him (with a focus on his English texts and translations). It also covers his ordination into the Church of England and subsequent career as a chaplain to Charles Howard, earl of Nottingham. It also elucidates his previously unknown life as a curate in the parish of St Nicholas, Deptford and as a deacon and priest St Pancras, Soper Lane, and finally his sermons at Paul’s Cross in the grounds of St Paul’s Cathedral. Fleming’s legacy of at least 52 printed books, which includes original godly protestant treatises, English translations of Latin and Greek classical works, and books commemorating unusual occasions, have ensured that his name lived on in bibliographic catalogues. Since the 1950s a few scholars have considered Fleming’s work on Holinshed’s Chronicles as significant contributions to the text. However, the subsequent articles that have been written about him have been narrow in scope and at times unreliable. Recent studies of Fleming have considered him only as a minor writer, yet this thesis demonstrates that he was a literary figure of considerable significance. Fleming made an important contribution to the emerging public sphere, as foregrounded by Jurgen Habermas, that was lauded by his contemporaries but he has largely slipped from view. Before this doctoral research little was known about Fleming’s career as a preacher in the Church of England, a career in which he proved just as diligent as when he was a “learned corrector” of books. The aim of this thesis has been to throw fresh light on the multi-faceted career of Abraham Fleming and establish him as a leading figure in late-Sixteenth century political and print culture

Procolipase gene : no association with early-onset obesity or fat intake

Copyright 2009 S. Karger AG, Basel.Peer reviewedPublisher PD

Factors that influence participation in physical activity for anxiety or depression: a synthesis of qualitative evidence

This is a protocol for a Cochrane Review (Qualitative). The objectives are as follows:. Main objective: To identify the factors that create barriers or facilitate physical activity for people with a diagnosis of anxiety or depression from the perspectives of service users, carers, service providers and practitioners to help inform the design and implementation of interventions that promote physical activity. The overall aim of this review is to identify, appraise, and synthesise qualitative research evidence on the barriers and facilitators to engaging in physical activity in general lifestyle settings or as part of an intervention designed to increase physical activity for people with anxiety and depression. This will allow us to identify factors that create barriers and facilitators of physical activity in this population to inform the development, design, and implementation of future interventions. We will also integrate the findings from the QES with the two associated effectiveness reviews (Cooney 2014; Larun 2006). We will communicate our findings to public health commissioners and other stakeholders

Sub-percent Photometry: Faint DA White Dwarf Spectophotometric Standards for Astrophysical Observatories

We have established a network of 19 faint (16.5 mag $< V <$19 mag) northern and equatorial DA white dwarfs as spectrophotometric standards for present and future wide-field observatories. Our analysis infers SED models for the stars that are tied to the three CALSPEC primary standards. Our SED models are consistent with panchromatic Hubble Space Telescope ($HST$) photometry to better than 1%. The excellent agreement between observations and models validates the use of non-local-thermodynamic-equilibrium (NLTE) DA white dwarf atmospheres extinguished by interstellar dust as accurate spectrophotometric references. Our standards are accessible from both hemispheres and suitable for ground and space-based observatories covering the ultraviolet to the near infrared. The high-precision of these faint sources make our network of standards ideally suited for any experiment that has very stringent requirements on flux calibration, such as studies of dark energy using the Large Synoptic Survey Telescope (LSST) and the Wide-Field Infrared Survey Telescope ($WFIRST$).Comment: 46 pages, 23 figures, 8 tables, accepted for publication in ApJ

Driving impairment and crash risk in Parkinson disease

OBJECTIVES: To provide the best possible evidence base for guiding driving decisions in Parkinson disease (PD), we performed a meta-analysis comparing patients with PD to healthy controls (HCs) on naturalistic, on-the-road, and simulator driving outcomes. METHODS: Seven major databases were systematically searched (to January 2018) for studies comparing patients with PD to HCs on overall driving performance, with data analyzed using random-effects meta-analysis. RESULTS: Fifty studies comprising 5,410 participants (PD = 1,955, HC = 3,455) met eligibility criteria. Analysis found the odds of on-the-road test failure were 6.16 (95% confidence interval [CI] 3.79-10.03) times higher and the odds of simulator crashes 2.63 (95% CI 1.64-4.22) times higher for people with PD, with poorer overall driving ratings also observed (standardized mean differences from 0.50 to 0.67). However, self-reported real-life crash involvement did not differ between people with PD and HCs (odds ratio = 0.84, 95% CI 0.57-1.23, p = 0.38). Findings remained unchanged after accounting for any differences in age, sex, and driving exposure, and no moderating influence of disease severity was found. CONCLUSIONS: Our findings provide persuasive evidence for substantive driving impairment in PD, but offer little support for mandated PD-specific relicensure based on self-reported crash data alone, and highlight the need for objective measures of crash involvement

Interprofessional education: Nurse – medic simulation initiatives

INTRODUCTION Interprofessional (IP) simulation improves team performance and communication skills1,2 IP simulation was established with Cardiff University medical and adult nursing students as part of IP education3. The objective was to evaluate students’ attitudes towards IP team working. METHODS Students were invited to attend simulation sessions of up to 3.5 hours duration and included a range of scenarios: stroke, seizure, cardiac arrest, sepsis using high fidelity mannequins in a simulated ward environment. A facilitator led post session debrief was conducted. Students were asked to complete the 10 item SPICE-R evaluation tool at the end of each session. RESULTS Evaluation is ongoing, of the n=77 evaluations received so far, the majority of students strongly agreed IP education was beneficial in enhancing their education 69% (53/77), practice 68% (52/77), role understanding 62% (48/77), team-working 69% (53/77), increasing patient satisfaction 77% (59/77) and improving health outcomes 74%(52/77). Approximately half of students agreed health professionals should collaborate on interprofessional teams 49% (38/77) and their role within an IP team is clearly defined 57% (44/77). Students similarly agreed they understood others’ roles 43% (33/77) and clinical placements are an ideal place for health professional students to interact 43% (33/77). CONCLUSION We created a nurturing environment for students to work interprofessionally. Successful interprofessional team working helps patient outcomes. More work is needed to ensure students understand each other’s role and to explore further opportunities for IP simulation and evaluate the longer-term outcomes and impact of IP simulation on patient care. References 1.Bulijac-Samardzic et al. Interventions to improve team effectiveness within health care: a systematic review of the past decade. Human Resource Health. 2020; 18(1):2 doi.org/10.1186/s12960-019-0411-3 2.Blackmore A, Kasfiki EV and Purva M. Simulation-based education to improve communication skills: a systematic review of the past decade. Human Resource Health. 2020; 18(1):2 doi.org/10.1186/s12960-019-0411- C3. 3. WHO (World Health Organisation) (2010) Framework for Action on Interprofessional Education and Collaborative Practice, Framework for action on interprofessional education & collaborative practice (who.int) [Accessed 13.1.23]

Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach.

Olfactory ensheathing cells (OECs) are neural crest-derived glia that ensheath bundles of olfactory axons from their peripheral origins in the olfactory epithelium to their central targets in the olfactory bulb. We took an unbiased laser microdissection and differential RNA-seq approach, validated by in situ hybridization, to identify candidate molecular mechanisms underlying mouse OEC development and differences with the neural crest-derived Schwann cells developing on other peripheral nerves. We identified 25 novel markers for developing OECs in the olfactory mucosa and/or the olfactory nerve layer surrounding the olfactory bulb, of which 15 were OEC-specific (that is, not expressed by Schwann cells). One pan-OEC-specific gene, Ptprz1, encodes a receptor-like tyrosine phosphatase that blocks oligodendrocyte differentiation. Mutant analysis suggests Ptprz1 may also act as a brake on OEC differentiation, and that its loss disrupts olfactory axon targeting. Overall, our results provide new insights into OEC development and the diversification of neural crest-derived glia.Cambridge Commonwealth Trust Cambridge Philosophical Societ