24,572 research outputs found
Hempstead Union Free School District and United Public Service Employees Union
In the matter of the fact-finding between the Hempstead Union Free School District, employer, and the United Public Service Employees Union, union. PERB case no. M2009-300. Before: Stuart L. Bass, fact finder
Analysis of SPDEs Arising in Path Sampling Part I: The Gaussian Case
In many applications it is important to be able to sample paths of SDEs
conditional on observations of various kinds. This paper studies SPDEs which
solve such sampling problems. The SPDE may be viewed as an infinite dimensional
analogue of the Langevin SDE used in finite dimensional sampling. Here the
theory is developed for conditioned Gaussian processes for which the resulting
SPDE is linear. Applications include the Kalman-Bucy filter/smoother. A
companion paper studies the nonlinear case, building on the linear analysis
provided here
Cooperative Stimulation of Dendritic Cells by Cryptococcus neoformans Mannoproteins and CpG Oligodeoxynucleotides
While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens. Cryptococcus neoformans mannoproteins (MP) synergized with CpG-containing oligodeoxynucleotides to stimulate enhanced production of proinflammatory cytokines and chemokines from murine conventional and plasmacytoid DC. Synergistic stimulation required the interaction of mannose residues on MP with the macrophage mannose receptor (MR), CD206. Moreover, synergy with MP was observed with other TLR ligands, including tripalmitoylated lipopeptide (Pam3CSK4), polyinosine-polycytidylic acid (pI:C), and imiquimod. Finally, CpG enhanced MP-specific MHC II-restricted CD4+ T-cell responses by a mechanism dependent upon DC expression of CD206 and TLR9. These data suggest a rationale for vaccination strategies that combine mannosylated antigens with TLR ligands and imply that immune responses to naturally mannosylated antigens on pathogens may be greatly augmented if TLR and MR are cooperatively stimulated.National Institutes of Health (RO1 AI25780, RO1 AI37532, K08 AI 53542
Variants within the MMP3 gene are associated with achilles tendinopathy: possible interaction with the COL5A1 gene
Objectives: Sequence variation within the COL5A1 and TNC genes are known to associate with Achilles tendinopathy. The primary aim of this case-control genetic association study was to investigate whether variants within the matrix metalloproteinase 3 (MMP3) gene also contributed to both Achilles tendinopathy and Achilles tendon rupture in a Caucasian population. A secondary aim was to establish whether variants within the MMP3 gene interacted with the COL5A1 rs12722 variant to raise risk of these pathologies.
Methods: 114 subjects with symptoms of Achilles tendon pathology and 98 healthy controls were genotyped for MMP3 variants rs679620, rs591058 and rs650108.
Results: As single markers, significant associations were found between the GG genotype of rs679620 (OR = 2.5, 95% CI 1.2 to 4.90, p = 0.010), the CC genotype of rs591058 (OR = 2.3, 95% CI 1.1 to 4.50, p = 0.023) and the AA genotype of rs650108 (OR = 4.9, 95% CI 1.0 to 24.1, p = 0.043) and risk of Achilles tendinopathy. The ATG haplotype (rs679620, rs591058, and rs650108) was under-represented in the tendinopathy group when compared to the control group (41% vs 53%, p = 0.038). Finally, the G allele of rs679620 and the T allele of COL5A1 rs12722 significantly interacted to raise risk of AT (p = 0.006). No associations were found between any of the MMP3 markers and Achilles tendon rupture.
Conclusion: Variants within the MMP3 gene are associated with Achilles tendinopathy. Furthermore, the MMP3 gene variant rs679620 and the COL5A1 marker rs12722 interact to modify the risk of tendinopathy. These data further support a genetic contribution to a common sports related injur
Acoustic characterization of crack damage evolution in sandstone deformed under conventional and true triaxial loading
We thank the Associate Editor, Michelle Cooke, and the reviewers, Ze'ev Reches and Yves Guéguen, for useful comments which helped to improve the manuscript. We thank J.G. Van Munster for providing access to the true triaxial apparatus at KSEPL and for technical support during the experimental program. We thank R. Pricci for assistance with technical drawings of the apparatus. This work was partly funded by NERC award NE/N002938/1 and by a NERC Doctoral Studentship, which we gratefully acknowledge. Supporting data are included in a supporting information file; any additional data may be obtained from J.B. (e-mail: [email protected]).Peer reviewedPublisher PD
Concave Switching in Single and Multihop Networks
Switched queueing networks model wireless networks, input queued switches and
numerous other networked communications systems. For single-hop networks, we
consider a {()-switch policy} which combines the MaxWeight policies
with bandwidth sharing networks -- a further well studied model of Internet
congestion. We prove the maximum stability property for this class of
randomized policies. Thus these policies have the same first order behavior as
the MaxWeight policies. However, for multihop networks some of these
generalized polices address a number of critical weakness of the
MaxWeight/BackPressure policies.
For multihop networks with fixed routing, we consider the Proportional
Scheduler (or (1,log)-policy). In this setting, the BackPressure policy is
maximum stable, but must maintain a queue for every route-destination, which
typically grows rapidly with a network's size. However, this proportionally
fair policy only needs to maintain a queue for each outgoing link, which is
typically bounded in number. As is common with Internet routing, by maintaining
per-link queueing each node only needs to know the next hop for each packet and
not its entire route. Further, in contrast to BackPressure, the Proportional
Scheduler does not compare downstream queue lengths to determine weights, only
local link information is required. This leads to greater potential for
decomposed implementations of the policy. Through a reduction argument and an
entropy argument, we demonstrate that, whilst maintaining substantially less
queueing overhead, the Proportional Scheduler achieves maximum throughput
stability.Comment: 28 page
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