Different calcium sources control somatic versus dendritic SK channel activation during action potentials

Small-conductance calcium-activated potassium (SK) channels play an important role in regulating neuronal excitability. While SK channels at the soma have long been known to contribute to the medium afterhyperpolarization (mAHP), recent evidence indicate

Dark-ages Reionization and Galaxy Formation Simulation -- XIX: Predictions of infrared excess and cosmic star formation rate density from UV observations

We present a new analysis of high-redshift UV observations using a semi-analytic galaxy formation model, and provide self-consistent predictions of the infrared excess (IRX) -- $\beta$ relations and cosmic star formation rate density. We combine the Charlot & Fall dust attenuation model with the Meraxes semi-analytic model, and explore three different parametrisations for the dust optical depths, linked to star formation rate, dust-to-gas ratio and gas column density respectively. A Bayesian approach is employed to statistically calibrate model free parameters including star formation efficiency, mass loading factor, dust optical depths and reddening slope directly against UV luminosity functions and colour-magnitude relations at z ~ 4-7. The best-fit models show excellent agreement with the observations. We calculate IRX using energy balance arguments, and find that the large intrinsic scatter in the IRX -$\beta$ plane is driven by the specific star formation rate. Additionally, the difference among the three dust models suggests a factor of two systematic uncertainty in the dust-corrected star formation rate when using the Meurer IRX - $\beta$ relation at z > 4.Comment: 15 pages, 10 figure. Accepted for publication in MNRA

Cortical feed-forward networks for binding different streams of sensory information

Different streams of sensory information are transmitted to the cortex where they are merged into a percept in a process often termed 'binding.' Using recordings from triplets of rat cortical layer 2/3 and layer 5 pyramidal neurons, we show that specifi

Dark-Ages Reionisation & Galaxy Formation Simulation XVI: The Thermal Memory of Reionisation

Intergalactic medium temperature is a powerful probe of the epoch of reionisation, as information is retained long after reionisation itself. However, mean temperatures are highly degenerate with the timing of reionisation, with the amount heat injected during the epoch, and with the subsequent cooling rates. We post-process a suite of semi-analytic galaxy formation models to characterise how different thermal statistics of the intergalactic medium can be used to constrain reionisation. Temperature is highly correlated with redshift of reionisation for a period of time after the gas is heated. However as the gas cools, thermal memory of reionisation is lost, and a power-law temperature-density relation is formed, $T = T_0(1+\delta)^{1-\gamma}$ with $\gamma \approx 1.5$. Constraining our model against observations of electron optical depth and temperature at mean density, we find that reionisation likely finished at $z_{\rm{reion}} = 6.8 ^{+ 0.5} _{-0.8}$ with a soft spectral slope of $\alpha = 2.8 ^{+ 1.2} _{-1.0}$. By restricting spectral slope to the range $[0.5,2.5]$ motivated by population II synthesis models, reionisation timing is further constrained to $z_{\rm{reion}} = 6.9 ^{+ 0.4} _{-0.5}$. We find that, in the future, the degeneracies between reionisation timing and background spectrum can be broken using the scatter in temperatures and integrated thermal history.Comment: 17 pages, 17 figures, Accepted for publication in MNRA

Dendritic mechanisms controlling spike-timing dependent synaptic plasticity

The ability of neurons to modulate the strength of their synaptic connections has been shown to depend on the relative timing of pre- and postsynaptic action potentials. This form of synaptic plasticity, called spike-timing-dependent plasticity (STDP), has become an attractive model for learning at the single-cell level. Yet, despite its popularity in experimental and theoretical neuroscience, the influence of dendritic mechanisms in the induction of STDP has been largely overlooked. Several recent studies have investigated how active dendritic properties and synapse location within the dendritic tree influence STDP. These studies suggest the existence of learning rules that depend on firing mode and subcellular input location, adding unanticipated complexity to STDP. Here, we propose a new look at STDP that is focused on processing at the postsynaptic site in the dendrites, rather than on spike-timing at the cell body

Correlates of children’s moderate and vigorous physical activity during weekdays and weekends

Background:Vigorous-intensity physical activity (VPA) may confer superior health benefits for children compared to moderate-intensity physical activity (MPA), but the correlates of MPA and VPA may differ. The study purpose was to investigate associations between selected enabling, predisposing, and demographic physical activity correlates, and MPA and VPA during weekdays and at weekends.Methods:Data were gathered from 175 children (aged 10 to 11 years). MPA and VPA were assessed using accelerometers. Correlates were measured at child and school levels. Multilevel analyses identified correlates that significantly predicted MPA and VPA.Results:Gender significantly predicted weekday MPA (P &lt; .001), and weekend MPA (P = .022) and VPA (P = .035). Weekday VPA was predicted by gender (P &lt; .001), indices of multiple deprivation score (P &lt; .003), BMI (P = .018), and school playground area (P = .046).Conclusions:Gender was the most significant correlate of MPA and VPA. Children most likely to engage in weekday VPA were boys with lower deprivation scores and BMI values, with access to larger playground areas.</jats:sec