Effect of Different Types of Physical Activity on Activities of Daily Living in Older Adults : Systematic Review and Meta-Analysis

Peer reviewedPostprin

Glycomacromolecules: Addressing challenges in drug delivery and therapeutic development

Carbohydrate-based materials offer exciting opportunities for drug delivery. They present readily available, biocompatible components for the construction of macromolecular systems which can be loaded with cargo, and can enable targeting of a payload to particular cell types through carbohydrate recognition events established in biological systems. These systems can additionally be engineered to respond to environmental stimuli, enabling triggered release of payload, to encompass multiple modes of therapeutic action, or to simultaneously fulfil a secondary function such as enabling imaging of target tissue. Here, we will explore the use of glycomacromolecules to deliver therapeutic benefits to address key health challenges, and suggest future directions for development of next-generation systems

The Digital Police Officer using linguistic analysis to identify cybercriminals

The aim of the Digital Police Officer project (DPO) is to identify cybercriminals based on their writing style. When a criminal underground forum is closed down, cybercriminals move to another one to further their illicit business. These users do not necessarily return with the same uername. We are producing a demo that can still identify such cybercriminals. We look at the way they communicate, analysing the characteristics of forum users (i.e. based on their vocabulary and grammar) to build a linguistic fingerprin

Functional magnetic resonance imaging : methods and applications

The technique of functional magnetic resonance imaging is rapidly moving from one of technical interest to wide clinical application. However, there are a number of questions regarding the method that need resolution. Some of these are investigated in this thesis. High resolutionf MRI is demonstrated at 3.0 T, using an interleaved echo planar imaging technique to keep image distortion low. The optimum echo time to use in fMRI experiments is investigated using a multiple gradient echo sequence to obtain six images, each with a different echo time, from a single free induction decay. The same data are used to construct T2* maps during functional stimulation. Various techniques for correcting the N/2 ghost are tested for use in fMRI experiments, and a method for removing the image artefact caused by external r. f. interference in a non-linearly sampled matrix is presented. The steps in the analysis of fMRI data are detailed, and two new non-directed analysis techniques, particularly for data from single events, as opposed to epoch based paradigms, are proposed. The theory behind software that has been written for fMRI data analysis is also given. Finally, some of the results from an fMRI study into the initiation of movement are presented, illustrating the power of single event experiments in the separation of cognitive processes

The gastric acid pocket is attenuated in H. pylori infected subjects

Objective Gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in Helicobacter pylori positive and negative volunteers in a Western population. Design We studied 31 H. pylori positive and 28 H. pylori negative volunteers, matched for age, gender and body mass index. Jumbo biopsies were taken at 11 predetermined locations from the gastro-oesophageal junction and stomach. Combined high-resolution pH metry (12 sensors) and manometry (36 sensors) was performed for 20 min fasted and 90 min postprandially. The squamocolumnar junction was marked with radio-opaque clips and visualised radiologically. Biopsies were scored for inflammation and density of parietal, chief and G cells immunohistochemically. Results Under fasting conditions, the H. pylori positives had less intragastric acidity compared with negatives at all sensors >1.1 cm distal to the peak lower oesophageal sphincter (LES) pressure (p<0.01). Postprandially, intragastric acidity was less in H. pylori positives at sensors 2.2, 3.3 and 4.4 cm distal to the peak LES pressure (p<0.05), but there were no significant differences in more distal sensors. The postprandial acid pocket was thus attenuated in H. pylori positives. The H. pylori positives had a lower density of parietal and chief cells compared with H. pylori negatives in 10 of the 11 gastric locations (p<0.05). 17/31 of the H. pylori positives were CagA-seropositive and showed a more marked reduction in intragastric acidity and increased mucosal inflammation. Conclusions In population volunteers, H. pylori positives have reduced intragastric acidity which most markedly affects the postprandial acid pocket

Assessment-led reform: creating a sustainable culture for WIL

This paper describes a process of assessment reform designed to enhance Work Integrated Learning (WIL) approaches for two science courses at an Australian university. The project used a mixed-method approach involving online surveys, interviews, focus groups and workshops to gather student, industry and course team knowledge and understanding of WIL approaches to curricula. The investigation centred on the perceived value of collaborating with industry to facilitate enhancements in authentic assessment and on the barriers to, and challenges in, achieving successful outcomes. The action-research project, WIL-on-Campus (WoC), found that assessments oriented toward the inclusion of authentic tasks and processes, that contribute to the employability learning and job-readiness of students, is deemed important to students, industry and academics. However, reforms to assessment practice and process are required. For greatest impact, this study found that assessment reform processes require two critical interdependent factors: the socialisation of the shared institutional value of embedded WIL approaches to assessment, and the provision of top-down support to enable academic course teams to implement the ‘imposed’ changes. Further to this, while academics viewed the changes in approach to assessment design as challenging, they also noted that a shift is timely and believed that a course-wide WIL approach is possible and advantageous

Functional magnetic resonance imaging : methods and applications

The technique of functional magnetic resonance imaging is rapidly moving from one of technical interest to wide clinical application. However, there are a number of questions regarding the method that need resolution. Some of these are investigated in this thesis. High resolutionf MRI is demonstrated at 3.0 T, using an interleaved echo planar imaging technique to keep image distortion low. The optimum echo time to use in fMRI experiments is investigated using a multiple gradient echo sequence to obtain six images, each with a different echo time, from a single free induction decay. The same data are used to construct T2* maps during functional stimulation. Various techniques for correcting the N/2 ghost are tested for use in fMRI experiments, and a method for removing the image artefact caused by external r. f. interference in a non-linearly sampled matrix is presented. The steps in the analysis of fMRI data are detailed, and two new non-directed analysis techniques, particularly for data from single events, as opposed to epoch based paradigms, are proposed. The theory behind software that has been written for fMRI data analysis is also given. Finally, some of the results from an fMRI study into the initiation of movement are presented, illustrating the power of single event experiments in the separation of cognitive processes

Cell origin and niche availability dictate the capacity of peritoneal macrophages to colonize the cavity and omentum

The relationship between macrophages of the peritoneal cavity and the adjacent omentum remains poorly understood. Here, we describe two populations of omental macrophages distinguished by CD102 expression and use an adoptive cell transfer approach to investigate whether these arise from peritoneal macrophages, and whether this depends upon inflammatory status, the origin of peritoneal macrophages and availability of the omental niches. We show that whereas established resident peritoneal macrophages largely fail to migrate to the omentum, monocyte-derived resident cells readily migrate and form a substantial component of omental CD102(+) macrophages in the months following resolution of peritoneal inflammation. In contrast, both populations had the capacity to migrate to the omentum in the absence of endogenous peritoneal and omental macrophages. However, inflammatory macrophages expanded more effectively and more efficiently repopulated both CD102(+) and CD102(−) omental populations, whereas established resident macrophages partially reconstituted the omental niche via recruitment of monocytes. Hence, cell origin determines the migration of peritoneal macrophages to the omentum and predisposes established resident macrophages to drive infiltration of monocyte-derived cells