9 research outputs found
Contamination assessment of Krakow Valleys Landscape Park’s surface and wastewaters
This research consisted of a physico-chemical evaluation of the streams and wastewaters within Krakow Valleys Landscape Park in the Kluczwody, Bolechowicka, Będkowska and Kobylańska valleys. The following set of parameters were determined in the samples: pH, Eh, conductivity, oxygen content, concentration of metals’ cations and selected anions. The results revealed that the wastewaters discharged as well as the streams that feed into the Rudawa river are mainly polluted with nitrates. Additionally, the examined wastewaters contained a high concentration of phosphate exceeding class II purity maximum permissible values
Clinical development success rates and social value of pediatric Phase 1 trials in oncology
ObjectivesDrug development trials must fulfill social value requirement but no estimates of value provided by pediatric Phase 1 trials in oncology exist. These trials involve a particularly vulnerable population. Our objective was to assess of surrogates of social value of Phase 1 trials performed in pediatric oncology: rates of approval of tested interventions, transition to further phases of testing and citation in subsequent primary research reports.MethodsWe performed an analysis on a subset of eligible trials included in a previous meta-analysis. That study systematically searched EMBASE and PubMed for small sample size, non-randomized, dose escalation pediatric cancer Phase 1 studies of any malignancy, assessing chemotherapy and/or targeted therapy and looked at risk and benefit. The current analysis assessed all studies in that review published between January 1st 2004 and December 31st 2013 for predictors of social value. This time range allowed for at least five years of subsequent development activity. Sources of data included FDA and EMA medicine databases (for approval), ClinicalTrials.gov and EU Clinical Trials Register (for transition) and Google Scholar (for citation).ResultsOne hundred thirty-nine trials enrolling 3814 patients met the eligibility criteria. Seven trials (5%) led to drugs being registered for pediatric use in therapy of cancer. Fifty-two (37%) transitioned to later phases of pediatric oncology trials according to ClinicalTrials.gov and/or EU Register. Over 90% of trials were cited by at least one subsequent primary research report or systematic review. Most of the citations were preclinical studies.ConclusionsOur analysis shows that treatments tested in pediatric Phase 1 trials in oncology have low rates of regulatory approval. However, a large proportion of Phase 1 trials inform further testing and development of tested interventions
An attempt to identify traffic related elements in snow
The main objective of this article is an attempt to use snow as an indicator in the process of assessing and identifying vehicle-derived elements pollution. The aim of the present study is to characterize traffic-related elements in snow collected from three sites: a parking place, a highway and a relatively unpolluted airfield. Several recent studies suggest that road traffic is considered to be one of the major sources of environmental pollution in urban areas. In order to avoid the problem of low emission from household furnaces, samples were collected far away from residential buildings. Snow located near roads with heavy traffic seems to be a very useful tool and indicator of traffic-related elements released into the environment. Snow acts as a natural filter for various chemical elements and particles. Snow is an efficient scavenger of aerosol and air pollutants, usually remains on the ground for sampling after the event; moreover, snowmelt contaminates soil. In the present study filtered (0.45 um) samples of melted snow were analyzed with ICP-MS. The results show significantly higher concentrations of elements in snow collected at the parking lot and at the highway when compared to samples taken from a relatively unpolluted airfield. Research on exploitation dust (break, tire, clutch) was performed with SEM-EDS
The effect of de-icing roads with salt on the environment in Krakow (Poland)
The de-icing of roads and streets in the winter season is a necessity in many European countries, where the mean day temperature drops below 0°C for long periods. Among the many chemicals used for winter road maintenance, the most popular in Poland is sodium chloride in various forms and mixtures, due to its relatively low price and availability. This agent, however, contributes to the increase of salinity in the soil environment and may lead to disturbances in soil properties and premature plant necrosis. The impact of the usage of chloride salts on the soil environment was researched in Krakow’s city centre by means of the examination of soil samples collected prior to the de-icing season (November) and afterwards (February) as well as snow samples taken in February. A general deterioration of the examined parameters (pH, conductivity, chloride concentrations, carbonate concentrations) was observed after the winter season, but still the results for most samples did not pose a serious threat to the soil environment or plants. This was mainly the result of the fact that the winter seasons in European countries have become increasingly mild and warm, which contributes to decreased usage of chloride salts. However, the state of soils in the Main Square was disturbing, as demonstrated by the clearly elevated chemical parameters of samples, despite a ban on the use of salt in this area. These results indicate the most probable reason for the withering of trees growing there, leading to them being frequently replaced
Contamination assessment of Krakow Valleys Landscape Park’s surface and wastewaters
Tyt. z nagłówka.Bibliogr. s. 330.This research consisted of a physico-chemical evaluation of the streams and wastewaters within Krakow Valleys Landscape Parkin the Kluczwody, Bolechowicka, Będkowska and Kobylańska valleys. The following set of parameters were determined in the samples: pH, Eh, conductivity, oxygen content, concentration of metals' cations and selected anions. The results revealed that the wastewaters discharged as well as the streams that feed into the Rudawa river are mainly polluted with nitrates. Additionally, the examined wastewaters contained a high concentration of phosphate exceeding class II purity maximum permissible values.Dostępny również w formie drukowanej.KEYWORDS: contamination, stream, wastewater, Krakow Valleys Landscape Park
Geochemical State of Wilga River Environment in Kraków (Poland)—Historical Aspects and Existing Issues
Aquatic systems are a very important part of the environment, which requires special attention due to the constant deterioration of the quality and quantity of water globally. Aquatic environments in Poland are mostly affected by the mining and smelting industry, which is especially visible in the south of the country, and one of such anthropogenically affected rivers is the Wilga—a small tributary of the Vistula River (the biggest river in Poland). For many years, the catchment area of the Wilga River accommodated a functioning industry that was based on the use of metals (fur, leather processing, foundry and galvanizing plants), as well as the “Solvay” Kraków Soda Works, which have left behind soda waste piles, and currently, along the course of the river, there are ongoing works connected with the construction of the “Łagiewnicka Route”, which required the relocation of a section of the Wilga river bed, among other things. To determine the general condition of the river, selected physico-chemical parameters were analysed in the water (pH, conductivity, anions: Cl−, N-NO3, P-PO4 and SO4 and cations: Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, Pb, Sr and Zn), suspended particulate matter and sediment (Al, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, Pb, Sr and Zn). Samples were taken before the relocation of the river bed (2019) and after its relocation (2021). The obtained data were compared with recorded historical data and this revealed that over the years, the condition of the Wilga environment has improved significantly, especially in terms of the contamination of sediments with metals, the concentrations of which fell several ten-fold. This is attributed to the closure of most industrial plants located within the river’s catchment area and to the modernization and legal regulation of the functioning of the remaining plants. An effect of leachates from the soda waste piles on the waters of Wilga has been observed (in the form of higher pH, mineralization and concentration of chlorides), which has however gradually decreased over time. However, no visible impact of road transport on the river’s environment has been observed, or any impact of the construction works or the related relocation of the river bed for that matter. The river should still be classified as polluted, but the level of this pollution has decreased significantly and the qualitative composition of the pollution has also changed
Chemistry and Microbiology of Urban Roof Runoff in Kraków, Poland with Ecological and Health Risk Implications
Urban rainwater samples, collected in various districts of Kraków during the period from the spring of 2019 to the winter of 2020, were investigated, and relevant risk implications were assessed. The contents of 31 components were determined, including: bacteria, fungi, pH, EC, Cl-, N-NO3, P-PO4, SO42-, SiO2, K, Mg, Ag, Al, Ba, Ca, Cu, K, Mg, Mo, Na, Pb, Sb, and Zn. The highest contents of the investigated elements were determined in the industrial (eastern) part of Kraków. The values of toxicity potential were <1, indicating a lack of ecological risk. The value of contamination degree indicated moderate rainwater contamination in all analyzed elements (Cdeg = 9.44). The total non-carcinogenic risk values, in both adults (hazard quotient (HQ) = 1.38) and children (HQ = 2.54), exceeded the acceptable level of one. Regarding individual elements in dermal contact, the acceptable level of 1 × 10−6 was exceeded in Pb (adults carcinogenic risk (CR) = 4.87 × 10−5, children CR = 2.23 × 10−5). The contents of the analyzed chemical compounds did not exceed the permissible levels adopted for drinking water; however, rainwater was significantly contaminated with respect to its microbiological parameters. Rainwater was suitable for non-potable use