30 research outputs found

    Host restriction factors in retroviral infection: promises in virus-host interaction

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    An Experimental Study of the Richtmyer-Meshkov Instability, Including Amplitude and Wavelength V'ations An experimental study of the Richtmyer-Meshkov instability, including amplitude and wavelength variations

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    Abstract: We report on results of an experimental study of the Rlchtmyer-Meshkov instability. The growth of the mixing region in the nonlinear regime is measured for a set of cases in which the amplitude and wavelength of the initial perturbation are varied systematically. The experiments are conducted on the Nova laser facility, and use a Nova hohlraum as a driver source to launch a high-Mach-number shock into a miniature shock tube attached to the hohlraum. The shock tube contains brominated plastic and low-density carbon foam as the two working fluids, with a micr~machined, triangular sawtooth interface between them serving as the initial perturbation. The sawtooth perturbation waveform is dominated by a single mode, and the perturbation amplitudes are chosen to expedite transition into the nonlinear phase of the instability. The shock, upon crossing the perturbation at the interface, instigates the Richtmyer-Meshkov instability. The resulting growth of the mixing region is diagnosed radiographically. Quantitative measurements of the temporal growth of the width of the mixing region are made for six different combinations of amplitude and wavelength, building upon prá¹½ ious results which employed a single amplitude/wavelength combination ]. Data from both experiment and supporting simulations suggest that the nonlinear growth of the mix width admits a logarithmic time dependence. The results also suggest that, properly normalized, the tot al mixing width grows in a nearly self-similar fashion, with a weak shape dependence

    Enhanced susceptibility of Ago1/3 double-null mice to influenza a virus infection

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    AbstracrtRNA interference (RNAi) is a critical component of many cellular antiviral responses in plants, invertebrates, and mammals. However, its in vivo role in host protection from the negative-sense RNA virus influenza virus type A (flu) is unclear. Here we have examined the role of RNAi in host defense to flu by analyzing Argonaute 1 and 3 double-knockout mice deficient in components of the RNA-induced silencing complex. Compared to littermate controls, flu-infected double-knockout mice exhibited increased mortality, consistent with more severe alveolitis and pneumonitis. These data indicate that optimal resistance to flu requires Argonaute 1 and/or 3. Enhanced mortality of double-knockout mice was not associated either with increased viral replication or with differential pulmonary recruitment or function of innate and adaptive immune cells. Given the absence of detectable immune defects, our results support the notion that the enhanced flu susceptibility of double-knockout mice arises from an intrinsic impairment in the ability of lung cells to tolerate flu-elicited inflammation. © 2012, American Society for Microbiology
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