Enriched Simplicial Presheaves and the Motivic Homotopy Category

We construct models for the motivic homotopy category based on simplicial functors from smooth schemes over a field to simplicial sets. These spaces are homotopy invariant and therefore one does not have to invert the affine line in order to get a model for the motivic homotopy category

Reversal of Nonlocal Vortex Motion in the Regime of Strong Nonequilibrium

We investigate nonlocal vortex motion in weakly pinning a-NbGe nanostructures, which is driven by a transport current I and remotely detected as a nonlocal voltage Vnl. At high I, the measured Vnl exhibits dramatic sign reversals that at low and high temperatures T occur for opposite polarities of I. The sign of Vnl becomes independent of that of the drive current at large abs(I). These unusual effects can be nearly quantitatively explained by a novel enhancement of magnetization, arising from a nonequilibrium distribution of quasiparticles at high T, and a Nernst-like effect resulting from local electron heating at low T

Nonlocal vs local vortex dynamics in the transversal flux transformer effect

In this follow-up to our recent Letter [F. Otto et al., Phys. Rev. Lett. 104, 027005 (2010)], we present a more detailed account of the superconducting transversal flux transformer effect (TFTE) in amorphous (a-)NbGe nanostructures in the regime of strong nonequilibrium in local vortex motion. Emphasis is put on the relation between the TFTE and local vortex dynamics, as the former turns out to be a reliable tool for determining the microscopic mechanisms behind the latter. By this method, a progression from electron heating at low temperatures T to the Larkin-Ovchinnikov effect close to the transition temperature Tc is traced over a range 0.26 < T/Tc < 0.95. This is represented by a number of relevant parameters such as the vortex transport entropy related to the Nernst-like effect at low T, and a nonequilibrium magnetization enhancement close to Tc. At intermediate T, the Larkin-Ovchinnikov effect is at high currents modified by electron heating, which is clearly observed only in the TFTE

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M&gt;70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0&lt;e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level