Effects of parental imprisonment on child antisocial behaviour and mental health: a systematic review

Parental imprisonment can cause many problems for the family left behind, including difficulty organising childcare, loss of family income, trouble maintaining contact with the imprisoned parent, stigma, and home, school and neighbourhood moves. Children and parents can be distressed by the separation. Children may respond by acting out or becoming withdrawn, anxious or depressed. We conducted an exhaustive search for studies that examined children's antisocial behaviour and mental health after parental imprisonment. We found 16 studies with appropriate evidence. These studies all showed that children of prisoners are more likely than other children to show antisocial and mental health problems. However, it was unclear whether parental imprisonment actually caused these problems. They might have been caused by other disadvantages in children's lives that existed before parental imprisonment occurred. Children of prisoners are a vulnerable group. More research is required to determine whether or not parental imprisonment causes an increase in child antisocial behaviour and mental health problems

Os deslocamentos de capitais no oeste americano do século XIX

Fundar um território ou um Estado no grande oeste dos Estados-Unidos do século XIX significa criar uma capital, e frequentemente deslocá-la até que o sítio escolhido corresponda ao projeto que sustentou a colonização anglo-americana. As hesitações desta política sumamente simbólica dependem da complexidade do povoamento, da instabilidade da economia regional, e de conflitos de interesses privados. Estudamos esta história a partir dos casos de Illinois e Minnesota que permitem ilustrar o conjunto de enfoques aos quais as elites foram confrontadas, querendo oferecer capitais significando o triunfo do processo de conquista territorial e simbolizando um conjunto de valores

Detection of milk oligosaccharides in plasma of infants

Human Milk Oligosaccharides (HMO) are one of the major components of human milk. HMO are non-digestible by the human gut, where they are known to play important functions as prebiotics and decoys for binding pathogens. Moreover, it has been proposed that HMO may provide sialic acids to the infant that are important in brain development, however this would require absorption of HMO into the bloodstream. HMO have consistently been found in the urine of humans and other mammals, suggesting systemic absorption. Here we present a procedure for the profiling of milk oligosaccharides (MO) in plasma samples obtained from 13 term infants hospitalized for surgery for congenital heart disease. The method comprises protein denaturation, oligosaccharide reduction and porous graphitized carbon solid phase extraction for purification followed by analysis using nHPLC-PGC-chip-TOF-MS. Approximately 15 free MO were typically observed in the plasma of human infants, including LNT, LDFP, LNFT, 3’SL, 6’SL, 3’SLN and 6’SLN, of which the presence was confirmed using fragmentation studies. A novel third isomer of SLN, not found in human or bovine milk was also consistently detected. Differences in the free MO profiles were observed between infants that were totally formula-fed and infants that received at least some part breast milk. Our results indicate that free MO similar in structure to those found in human milk and urine are present in the blood of infants. The method and results presented here will facilitate further research toward the possible roles of free MO in the development of the infant