The origin of pointing: Evidence for the touch hypothesis

Pointing gestures play a foundational role in human language, but up to now, we have not known where these gestures come from. Here, we investigated the hypothesis that pointing originates in touch. We found, first, that when pointing at a target, children and adults oriented their fingers not as though trying to create an “}arrow{” that picks out the target but instead as though they were aiming to touch it; second, that when pointing at a target at an angle, participants rotated their wrists to match that angle as they would if they were trying to touch the target; and last, that young children interpret pointing gestures as if they were attempts to touch things, not as arrows. These results provide the first substantial evidence that pointing originates in touch

Design of an integrated airframe/propulsion control system architecture

The design of an integrated airframe/propulsion control system architecture is described. The design is based on a prevalidation methodology that uses both reliability and performance. A detailed account is given for the testing associated with a subset of the architecture and concludes with general observations of applying the methodology to the architecture

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis

Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute. Chronic immune stimulation characterizes many autoimmune disorders. We hypothesized that repeated stimulation may cause a different T cell immune response in women than men. Microarray approaches were used to compare gene expression in T cells from healthy men and women with and without repeated stimulation. Four days following a single stimulation only 25% of the differentially expressed, gender-biased genes were expressed at higher levels in the women. In contrast, following restimulation 72% were more highly expressed in women. Immune response genes were significantly over-represented among the genes upregulated in women, and among the immune response genes, the inflammatory/cytotoxic effector genes interferon gamma (IFNG), lymphotoxin beta (LTB), granzyme A (GZMA), interleukin-12 receptor beta2 (IL12RB2), and granulysin (GNLY) were among those overexpressed to the greatest degree. In contrast, IL17A was the only effector gene more highly expressed in men. Estrogen response elements were identified in the promoters of half of the overexpressed immune genes in women, and in <10% of the male biased genes. The differential expression of inflammatory/cytotoxic effector molecules in restimulated female T cells may contribute to the differences in autoimmune diseases between women and men

The Recurrent Nature of Central Starbursts

New hydrodynamic models with feedback show that feedback driven turbulence and subsequent relaxation can drive recurrent starbursts, though most of these bursts fizzle due to premature, asymmetric ignition. Strong bursts are terminated when the turbulence inflates the multiphase central disk. The period between bursts is about twice a free-fall time onto the central disk. Transient spirals and bars are common through the burst cycle.Comment: 7 pages + 3 figs. Conf. paper for "Starbursts: from 30 Doradus to Lyman Break Galaxies," held at Inst. of Astronomy, Cambridge Univ., Sept. 6-10, 2004. Kluwer Academic Publishers, eds. R. de Grijs and R. M. Gonzalez Delgado + additional materia