catena-Poly[copper(I)-bis(μ-trifluoro­methane­sulfonato-κ2 O:O′)-copper(I)-bis(μ-trimethyl trithio­phosphite)-κ2 P:S;κ2 S:P]

The title compound, [Cu2(CF3SO3)2(C3H9PS3)2]n, crystallizes as infinite chains in which two trimethyl trithio­phosphite ligands and two trifluoro­methane­sulfonate anions bridge the essentially tetra­hedrally coordinated CuI ions in an alternating fashion. The P and one S atom of each trimethyl trithio­phosphite ligand are employed for coordination. The mol­ecular structure exhibits the rare motif of copper(I) bridged by two trifluoro­methane­sulfonate anions generating eight-membered rings

[Bis­(4-methyl-1,3-thia­zol-2-yl-κN)methane]­tricarbonyl­dichlorido­tungsten(II)

The title compound, [WCl2(C9H10N2S2)(CO)3], is a hepta­coordinate tungsten(II) complex with a capped–octa­hedral coordination sphere in which one CO ligand caps a face formed by a chloro ligand and the two other carbonyls. The chloro ligands are mutually trans positioned at an angle of 156.98 (7)°. The chelating bis­(4-methyl-1,3-thia­zol-2-yl)methane ligand coordinates with the imine N atoms. In the crystal, mol­ecules are linked into chains parallel to [201] by weak C—H⋯O contacts between the CH2 group of the bis­(4-methyl­thia­zol-2-yl)methane ligand and the O atom of the capping CO group

Bis(1,1,2,2-tetramethyldiphosphane-1,2-dithione-κ2 S,S′)gold(I) trifluoro­methane­sulfonate

In the title compound, [Au(C4H12P2S2)2](CF3SO3), the gold(I) atom is tightly bonded to two S atoms belonging to different ligand mol­ecules and forms two weaker contacts to the remaining S atoms. The coordination geometry around gold is inter­mediate between linear-dicoordinate and tetra­hedral with an S—Au—S angle of 161.49 (3)°

Structured immune work-up in healthy children with a first episode of severe bacterial infection: a 7-year single-center study

Background: Severe bacterial infections (SBI) in otherwise healthy children are rare and may represent an underlying impairment of the immune system including primary immunodeficiency (PID). However, it is unclear if and how children should be assessed. Methods: We retrospectively analyzed data from hospital records of previously healthy children aged 3 days to 18 years with SBI including pleuropneumonia, meningitis, and/or sepsis. Patients were diagnosed or immunologically followed-up between 2013/01/01 and 2020/03/31. Results: Out of 432 children with SBI, 360 children could be analyzed. Follow-up data were available for 265 (74%) children, of whom 244 children (92%) had immunological testing. Laboratory abnormalities were found in 51 of 244 patients (21%), with 3 deaths (1%). There were 14 (6%) children with immunodeficiency considered clinically relevant (3 complement deficiencies, 1 autoimmune neutropenia, 10 humoral immunodeficiencies) and 27 (11%) with milder humoral abnormalities or findings suggestive of delayed adaptive immune maturation. Conclusions: A substantial proportion of children with SBI may benefit from routine immunological testing, revealing (potentially) clinically relevant impaired immune function in 6-17% of children. The identification of immune abnormalities allows for specific counselling of families and optimization of preventive measures such as booster vaccinations to avoid future SBI episodes

Managed Evolution of Automotive Software Product Line Architectures: A Systematic Literature Study

The rapidly growing number of software-based features in the automotive domain as well as the special requirements in this domain ask for dedicated engineering approaches, models, and processes. Nowadays, software development in the automotive sector is generally developed as product line development, in which major parts of the software are kept adaptable in order to enable reusability of the software in different vehicle variants. In addition, reuse also plays an important role in the development of new vehicle generations in order to reduce development costs. Today, a high number of methods and techniques exist to support the product line driven development of software in the automotive sector. However, these approaches generally consider only partial aspects of development. In this paper, we present an in-depth literature study based on a conceptual model of artifacts and activities for the managed evolution of automotive software product line architectures. We are interested in the coverage of the particular aspects of the conceptual model and, thus, the fields covered in current research and research gaps, respectively. Furthermore, we aim to identify the methods and techniques used to implement automotive software product lines in general, and their usage scope in particular. As a result, this in-depth review reveals that none of the studies represent a holistic approach for the managed evolution of automotive software product lines. In addition, approaches from agile software development are of growing interest in this field

(m-Phenyl­enedimethyl­ene)bis­(triphenyl­phospho­nium) bis­[chlorido(penta­fluoro­phen­yl)aurate(I)] dichloro­methane disolvate

The title compound, (C44H38P2)[AuCl(C6F5)]2·2CH2Cl2, crystallizes with a twofold rotation axis through the central benzene ring in the bis-phospho­nium dication. In the crystal, the dications and anions are ordered into columns running parallel to the c axis by contacts of the pro-ylidic CH2 groups with the Cl atom of one and an ortho-F atom of another anion. The space between the columns is occupied by CH2Cl2 solvent mol­ecules

[(3-Methylphenyl)(triphenylphosphonio)methanide-κC]triphenyl­phospho­rane}(penta­fluoro­phenyl-κC)gold(I) diethyl ether solvate

The metal atom in the title ylid–gold(I) adduct, [Au(C6F5)(C26H23P)]·C4H10O, exists in a linear coordination environment [C—Au—C = 174.1 (2)°]. The mol­ecule has a short intra­molecular contact involving an aromatic H atom (Au⋯H = 2.64 Å); two adjacent mol­ecules are linked by an Au⋯Hylid inter­action (Au⋯H = 3.14 Å)

Bis[μ-1,2-bis­(diphenyl­phosphino)ethane-κ2 P:P′]digold(I)(Au—Au) bis­(trifluoro­methane­sulfonate) acetonitrile disolvate

The title compound, [Au2(C26H24P2)2](CF3SO3)2·2CH3CN, comprises a cyclic cation with a short intra­molecular aurophilic inter­action of 2.9220 (3) Å. The trifluoro­methane­sulfonate anions and acetonitrile solvent mol­ecules are located in channels formed by the complex cations that run along the crystallographic c axis. Each counter-anion is also engaged in a C—H⋯O contact with one of the methyl­ene H atoms of a 1,2-bis­(diphenyl­phosphino)ethane (dppe) ligand; another C—H⋯O contact involving an aromatic H atom is also observed

Integrators of the Cytoskeleton that Stabilize Microtubules

AbstractSensory neurodegeneration occurs in mice defective in BPAG1, a gene encoding cytoskeletal linker proteins capable of anchoring neuronal intermediate filaments to actin cytoskeleton. While BPAG1 null mice fail to anchor neurofilaments (NFs), BPAG1/NF null mice still degenerate in the absence of NFs. We report a novel neural splice form that lacks the actin-binding domain and instead binds and stabilizes microtubules. This interaction is functionally important; in mice and in vitro, neurons lacking BPAG1 display short, disorganized, and unstable microtubules defective in axonal transport. Ironically, BPAG1 neural isoforms represent microtubule-associated proteins that when absent lead to devastating consequences. Moreover, BPAG1 can functionally account for the extraordinary stability of axonal microtubules necessary for transport over long distances. Its isoforms interconnect all three cytoskeletal networks, a feature apparently central to neuronal survival