Foreign policy convergence in Pacific Asia : the evidence from voting in the UN General Assembly

Research Highlights and Abstract Research Highlights Comparative assessment of three indexes of voting cohesion Demonstrates the strong shared orientation towards global affairs among states in the Pacific Asian region, especially ASEAN and China, which is greater than that of the EU Shows the widespread reluctance of most Pacific Asian states publicly to criticize human rights abuses Shows the estrangement of the US from the foreign policy orientations of Pacific Asian states, even Japan and South Korea This article aims to do three things: (i) compare three different indexes for assessing the voting cohesion of regional groups of states in the UN General Assembly; (ii) use these indexes to assess the foreign policy convergence of states in Pacific Asia on global issues between 1974 and 2008; (iii) compare the extent of that convergence with the European Union (EU). All three indexes show a high degree of convergence in the voting records of states in Pacific Asia, but particularly in ASEAN, which is higher than in the EU. The most frequent cause of divergence since the end of the Cold War has been the reluctance of most states in the region, apart from Japan and South Korea, publicly to criticize the human rights records of other states. Although there are variations, the results also reveal the divergence in voting between states throughout the region and the US

Phased, chromosome-scale genome assemblies of tetraploid potato reveals a complex genome, transcriptome, and predicted proteome landscape underpinning genetic diversity

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome. Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity, including altered coding and transcript sequences, preferential allele expression, and structural variation that collectively result in a highly complex transcriptome and predicted proteome, which are distributed across the homologous chromosomes. Wild species contribute to the extensive allelic diversity in tetraploid cultivars, demonstrating ancestral introgressions predating modern breeding efforts. As a clonally propagated autotetraploid that undergoes limited meiosis, dysfunctional and deleterious alleles are not purged in tetraploid potato. Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function, complicating breeder’s efforts to reduce genetic load. The StCDF1 locus controls maturity, and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner. Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous, diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids

Phased, chromosome-scale genome assemblies of tetraploid potato reveals a complex genome, transcriptome, and predicted proteome landscape underpinning genetic diversity

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome. Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity including altered coding and transcript sequences, preferential allele expression, and structural variation that collectively result in a highly complex transcriptome and predicted proteome which are distributed across the homologous chromosomes. Wild species contribute to the extensive allelic diversity in tetraploid cultivars, demonstrating ancestral introgressions predating modern breeding efforts. As a clonally propagated autotetraploid that undergoes limited meiosis, dysfunctional and deleterious alleles are not purged in tetraploid potato. Nearly a quarter of the loci bore mutations predicted to have a high negative impact on protein function, complicating breeder’s efforts to reduce genetic load. The StCDF1 locus controls maturity and analysis of six tetraploid genomes revealed 12 allelic variants correlated with maturity in a dosage dependent manner. Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous, diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids

Phased, chromosome-scale genome assemblies of tetraploid potato reveals a complex genome, transcriptome, and predicted proteome landscape underpinning genetic diversity

Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome. Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity, including altered coding and transcript sequences, preferential allele expression, and structural variation that collectively result in a highly complex transcriptome and predicted proteome, which are distributed across the homologous chromosomes. Wild species contribute to the extensive allelic diversity in tetraploid cultivars, demonstrating ancestral introgressions predating modern breeding efforts. As a clonally propagated autotetraploid that undergoes limited meiosis, dysfunctional and deleterious alleles are not purged in tetraploid potato. Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function, complicating breeder’s efforts to reduce genetic load. The StCDF1 locus controls maturity, and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner. Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous, diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids

‘Neutrality: A really dead concept?’ A reprise

This article approaches ‘neutrality’ as an essentially contested concept and traces its meaning and purpose over centuries-long historical timelines and situated political, societal and security contexts. It distinguishes neutrality from other concepts such as ‘neutralization’ ‘non-belligerency’, ‘non-alignment’, ‘military non-alignment’, ‘military neutrality’ and ‘non-allied’. The article explains the politics of defining neutrality in the current European political and legal landscape and in the context of shifting definitions and practices of war, peace, security and state sovereignty. This episteme-based analysis focuses on changes to neutrality in accordance with the rise and fall of particular empires and international actors over time, and changes to its status linked to the development and reification of particular meta-theoretically-based subfields of International Relations and Political Science, setting the background to this special issue of Cooperation and Conflict. A renewed emphasis on the normative aspects of neutrality (i.e. the role of domestic values, politics, preferences, history and mass publics in foreign policy formulation) is achieved by employing a range of perspectives, characterized by increased pluralism in levels of analysis and theoretical approaches. Through this pluralism, authors engage with (1) the strategic and normative drivers underpinning the norm of neutrality, (2) the potential for neutrals to serve as norm entrepreneurs in the field of peace promotion, (3) the tenuous legal status of elites’ quasi-neutral foreign policy constructions underpinned by tensions between discourses and practices and (4) the discursive strategies underpinning the move from neutral states’ traditional forms of neutrality to what is termed ‘post-neutrality’ in the current politico-legal context

Les protéines de pathogenèse PR-10 des végétaux

peer reviewedThe PR-10 protein family contains proteins related to pathogenesis and allergenic proteins. They are acidic proteins, with an intracellular localization, usually members of a multigene family and ubiquitous among plant kingdom. They contain a highly conserved motif, identified as a phosphate binding site. Even if the biological function of these proteins is still unknown, many indicators seem to favour the hypothesis of an RNAse activity. Moreover, one of them seems to be a cytokinin specific binding protein. Besides, PR-10 protein expression induction under cytokinin treatment was observed with the Catharanthus roseus CrPR-10a protein. Here, we present the evidence of a significative increase of endogenous cytokinin contents in leaves of transgenic Tobacco plants over-expressing the CrPR-10a protein.Les protéines PR-10 regroupent à la fois des protéines de pathogenèse et des protéines allergènes. Ce sont des protéines acides, à localisation intracellulaire, généralement membres d’une famille multigénique et ubiquitaires à travers le règne végétal. Elles contiennent un motif hautement conservé, identifié comme un site de fixation de groupements phosphates. Même si la fonction biologique de ces protéines est encore mal définie, plusieurs indications semblent être favorables à l’hypothèse d’une activité RNAse. De plus, l’une d’entre elles serait dotée de la faculté de former des complexes spécifiques avec des cytokinines. En outre, une induction de l’expression des protéines PR-10 sous l’action de traitement par des cytokinines a été observée dans le cas de la protéine CrPR-10a chez Catharanthus roseus. La sur-expression de cette protéine PR-10 chez le Tabac, nous a permis de mettre en évidence une augmentation statistiquement significative des teneurs endogènes de certaines cytokinines

Structural genome analysis in cultivated potato taxa.

The common potato (Solanum tuberosum L.) is an important staple crop with a highly heterozygous and complex tetraploid genome. The other taxa of cultivated potato contain varying ploidy levels (2X–5X), and structural variations are common in the genomes of these species, likely contributing to the diversification or agronomic traits during domestication. Increased understanding of the genomes and genomic variation will aid in the exploration of novel agronomic traits. Thus, sequencing data from twelve potato landraces, representing the four ploidy levels, were used to identify structural genomic variation compared to the two currently available reference genomes, a double monoploid potato genome and a diploid inbred clone of S. chacoense. The results of a copy number variation analysis showed that in the majority of the genomes, while the number of deletions is greater than the number of duplications, the number of duplicated genes is greater than the number of deleted ones. Specific regions in the twelve potato genomes have a high density of CNV events. Further, the auxin-induced SAUR genes (involved in abiotic stress), disease resistance genes and the 2-oxoglutarate/Fe(II)-dependent oxygenase superfamily proteins, among others, had increased copy numbers in these sequenced genomes relative to the references