Einflussfaktoren auf das Überleben und die Rezidivfreiheit von 1502 Patienten mit Schilddrüsenkarzinom:eine retrospektive Analyse

Es wurden die Krankenakten von 1502 Patienten mit differenziertem Schilddrüsenkarzinom ausgewertet, die sich in der Zeit von 1988 bis 2007 vorstellten. Endpunkte waren Gesamtüberleben, krankheitsspezifisches Überleben, rezidivfreies Überleben. Auch Nebenwirkungen einer Hochdosis-RIT wurden untersucht. Ergebnisse: In der univariaten Analyse statistisch signifikante Einflussfaktoren sind: Alter, Geschlecht, T-, N-, M-Stadium, histologische und R0/1/2-Resektion. Beim ereignisfreien Überleben kam auch noch die Durchführung einer Neck Dissection als univariater Einflussfaktor hinzu. Bei der multivariaten Analyse verifizierten sich Alter, Geschlecht, T-, M-Stadium und histologische Differenzierung als signifikante Einflussfaktoren; beim ereignisfreien Überleben auch N-Stadium, nicht die histologische Differenzierung. 119 Patienten hatten eine Hochdosis-RIT (> 22 GBq 131I). Davon bekamen 18 transiente Blutbildveränderungen, 1 Patient erkrankte im Follow-up-Zeitraum an einer Leukämie

Wild als Bioindikator auf dem Gebiet der neuen Bundeslaender

The report gives a survey of the samples (muscle, liver and kidney) of one year old roe and red deer investigated between 1992 and 1994. A total of 179 animals from the areas Hochharz, Duebener Heide and Ostufer Mueritz was investigated for environmental chemicals (Pb, Cd, Hg, 6 PCB, 21 pesticides). Beside differences in the concentrations of Cd in kidneys and livers of fawns and roebucks dependent on age there are differences in the concentrations of Cd in kidneys and livers between roe deer and red deer. The concentrations of Cd of young red deer are lower wherea young red deer possibly reacts stronger to Pb exposition. There are differences in the concentration of Cd and Pb in livers and kidneys between the areas where the samples had been taken. Partially the concentrations of b-HCH, a-HCH, PCB 138, PCB 153 and PCB 180 in liver exceeded the maximum permissible value. Despite significantly higher concentrations of b-HCH (partially also g- and a-HCH) with roebucks from the Duebener Heide area in 1994 tendentious differences between the areas are hardy noticeable. Tendentious differences between the areas could not be detected in the course of the three years of investigation. (orig.)SIGLEAvailable from TIB Hannover: RN 8908(99-015) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekUmweltbundesamt, Berlin (Germany); Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)DEGerman

Development of Non-Targeted Mass Spectrometry Method for Distinguishing Spelt and Wheat

Food fraud, even when not in the news, is ubiquitous and demands the development of innovative strategies to combat it. A new non-targeted method (NTM) for distinguishing spelt and wheat is described, which aids in food fraud detection and authenticity testing. A highly resolved fingerprint in the form of spectra is obtained for several cultivars of spelt and wheat using liquid chromatography coupled high-resolution mass spectrometry (LC-HRMS). Convolutional neural network (CNN) models are built using a nested cross validation (NCV) approach by appropriately training them using a calibration set comprising duplicate measurements of eleven cultivars of wheat and spelt, each. The results reveal that the CNNs automatically learn patterns and representations to best discriminate tested samples into spelt or wheat. This is further investigated using an external validation set comprising artificially mixed spectra, samples for processed goods (spelt bread and flour), eleven untypical spelt, and six old wheat cultivars. These cultivars were not part of model building. We introduce a metric called the D score to quantitatively evaluate and compare the classification decisions. Our results demonstrate that NTMs based on NCV and CNNs trained using appropriately chosen spectral data can be reliable enough to be used on a wider range of cultivars and their mixes