Diagnostic, and therapeutic challenges In HIV+ patient, presented with left-sided Haemiparesis and MRI changes

Neurological features occur during the later stages of HIV infection. The most common manifestations are opportunistic infections like cerebral toxoplasmosis and progressive multifocal leukoencephalopathy, as well as malignant lymphomas like primary EBV associated CNS lymphoma. We present a case of a 21-yearold man, diagnosed as HIV+ in 2010. The patient receives HAART (kivexa/kaletra) from 13.08.2013 to date with poor adherence. The current complaints began two weeks ago with weakness in the lower extremities, gait disturbances and headache. The neurological examination at the admission time showed no meningeal signs, weakened tendon reflexes in left limbs, absent abdominal reflexes, central facial palsy on the left, positive Babinski sign. Upon admission to the hospital the patient presented with CD 4-34c/mm³, VL- 2180 c/ml. Cerebral spinal fluid viral load was <20 c/ml. The results of the serological and virological tests from cerebral spinal fluid were: PCR EBV (-); PCR CMV (-); IgM EBV (-); IgG CMV (-); T.gondii IgM (-); IgG(-); PCR for pathogenic free-living amoeba (-). MRI: space occupying lesion, interpreted as a lymphoma, MRI after 6 months: progression of the lesion. A biopsy of peripheral lymph node showed nonspecific finding. The patient was put on patogenetic treatment against cerebral edema, treatment against T. gondii infection (clindamycin, co-trimoxazole), and gancyclovir, meronem, fungolon, ART as well. The patient was without precise, laboratory confirmed diagnosis, but the general condition is better

Integrated mapping of ecosystems and assessment of forest ecosystem services at river basin scale

Ecosystems provide various goods and services to society and their valuation is among the main objectives of the concept of ecosystem services (ES). The mapping of ecosystems is the main building block of the whole process of the Mapping and Assessment of Ecosystems and their Services (MAES). The analyses of the ecosystem data produced during the implementation of the national methodology for mapping ecosystems in Bulgaria (MAES BG) reveal some problems that may cause confusion in cases of integrated assessment of all ecosystem types. In this paper, we present an approach that enables formulation of a uniform spatial dataset based on the mapping of the main ecosystem types, that can be used for mapping of ES at a river basin scale. It has been applied to the upper part of the Ogosta River basin and the result is a topologically correct uniform spatial data layer. The approach gives one possible solution to problems related to the different sources of information and the discrepancies between ecosystem types in the national mapping of ecosystems in Bulgaria. It is based on the use of a uniform spatial framework that outlines the ecosystem types and sets the initial database for further mapping. This ensures a topologically correct spatial dataset for the ecosystems and a background for further updates for each ecosystem at the different levels of MAES typology. The most appropriate spatial basis for the territory of Bulgaria is the database for the physical blocks of the Ministry of Interior. Its application to the studied river basin gives encouraging results and can be used as an example for similar areas. Further development of the approach will ensure the mapping of the forest ecosystems at level 3 of the MAES BG typology and more precise delineation of the grassland, heathland, freshwater, and sparsely vegetated ecosystems

Modeling water regulation ecosystem services: A review in the context of ecosystem accounting

Natural Capital Accounting (NCA) has evolved rapidly in recent years through substantial efforts of both international organizations and the scientific community. Water regulation ecosystem services (ES) are key elements of regulating services in ecosystem accounting, with most relevant studies strongly relying on models for ES quantification up to now. In this paper, we provide a review of modeling efforts for water regulation ES based on 148 scientific papers, properly systematized, analyzed and interpreted by using a detailed and structured original template. We examined emerging trends and gaps in model applications and the readiness to integrate them into the NCA and SEEA-EA frameworks. We propose a classification scheme which organizes the 92 different models and modeling approaches identified in the review process into eight model categories so that this scheme can be efficiently used in the water ES assessment of and for further integration into the accounting framework. Among the models, the hydrologic model SWAT and the modeling tool InVEST are by far the most popular. The results of the review revealed differences between the general ES literature and the accounting-related papers. Moreover, our analysis sets the basis for useful recommendations of which model categories are the most appropriate for the water regulation ES, included in the SEEA-EA reference list. Based on the number of relevant papers, the reliability and the confidence level of the recommendations for the use of models have been incorporated in our analysis. We highlight as model category with the highest confidence the ones relative to quantification water flow and flood control service aiming at ES accounting. Models for erosion control ES can only be recommended with a lower confidence, while for water purification the results lack clear evidence for using a particular group of models. Based on the research findings we identified the main research priorities on model integration in the accounting of water regulation ES: 1) further development of guidelines for the use of models in ecosystem accounting; 2) analyses of the spatial aspects of the model towards a clear distinction between ecosystem service supply and use; and 3) development of integrated modeling approaches for water regulation ES accounting. © 2022 The Author(s

A review of regulating ecosystem services in the context of urban planning

There is a high growing demand for regulating ecosystem services such as air quality regulation, regulation of air temperature and humidity, and flood regulation, in urban ecosystems which is important for urban planning. A comprehensive review of the current studies of the urban ecosystem, regulating ecosystem services, and their connection with urban planning actions is needed. The current paper presents such a review conducted in six stages to evaluate the state-of-the-art of regulating ecosystem services and their relationship with urban planning. It includes 58 papers selected after a precise keywords search and developed by publication screening, defining indicators, developing an assessment template, and meta-analysis of the results. The analyses are focused on spatial data used in the studies, the methods applied for ecosystem services assessment, and the relationships between regulating ecosystem services, urban planning, and green infrastructure. The most studied regulating ecosystem services within reviewed publications are regulation of chemical composition of atmosphere and oceans, regulation of temperature and humidity, including ventilation and transpiration, and hydrological cycle and water flow regulation (including flood control, and coastal protection). Although urban planning-related papers are only 1/3 of the pool of papers, appropriate results have been obtained for assessing the urban planning-regulating ecosystem services relation. The review also identified some significant knowledge gaps that can be used as a starting point for future studies

Mapping of ecosystems in Bulgaria for the needs of natural heritage assessment

The main purpose of the paper is to explore the relationship between the CORINE Land Cover (CLC) classification and the MAES typology in order to develop a basis for mapping of ecosystems at national level in Bulgaria, which could ensure a spatial framework for mapping and assessment of the ecosystem services provided by the natural heritage. Identifying the necessary data for our purposes, we found that, in spatial terms, CLC data is the only appropriate data source. The subtypes of ecosystems at Level 3 of the classification of ecosystems in Bulgaria (based on the European MAES classification) are identified as mapping units. Firstly, we decided to analyze the links between the CLC and the MAES BG classes through five categories of correspondence: 1) full correspondence – one CLC class corresponds to one MAES BG subtype; 2) multi-directional links – one or more CLC classes correspond to one MAES BG subtype; 3) discrepancies that necessitate further analyses; 4) CLC classes that are not found in Bulgaria; 5) MAES BG subtypes that have no correspondence to a CLC class. Secondly, we prepared a comparison table to determine the correspondence between the CLC classes and ecosystem subtypes, which we integrated into the GIS environment. Thirdly, we developed an algorithm for modifications of the spatial distribution of ecosystem subtypes. The algorithm was applied particularly to grasslands, where at Level 3 of CLC there are two classes of "grassland”, whereas at Level 3 of the classification of ecosystems in Bulgaria, the subtypes are five. This algorithm was applied to the 2018 CLC spatial data so as to develop a GIS database providing the basis for subsequent analyzes related to ecosystems. The database was used to delineate and map the ecosystems at national level in Bulgaria. Furthermore, a map of the potential of the natural heritage to provide ecosystem services was produced

Analysis of the national ecosystem database of Bulgaria: (Mis)matches with the MAES framework

The mapping of ecosystems is a significant element in the European Biodiversity Strategy and the results of its implementation should support the maintenance and restoration of ecosystems and their services. The quality of the spatial data is of crucial importance for the achievement of these goals. A methodological framework for Bulgaria in the form of nine separate methodologies has been developed in recent years. In this paper, we analyze the ecosystem typology for Bulgaria and the GIS database to assess the possibilities to develop a common database for the needs of integrated water management. The data analyses were carried out in two dimensions: 1) the typology and attributive data were analyzed by cross-tabular approach; and 2) the spatial data were analyzed by topology rules.  The results of the study reveal three main problems of the typology: 1) for some types it is developed to the fourth level while for others it is to the third level; 2) in some of the ecosystem types, especially in the freshwater ecosystems, different categories are mixed within a single hierarchical level; 3: there are duplicated numerical designations between grassland and forest ecosystems. This necessitates a revision of the typology and the development of a correct uniform classification to be used for the needs of integrated assessment. The topology analyses of the merged data from the eight ecosystem GIS layers show extremely large numbers of gaps and overlaps. The main reason is the use of different sources for the mapping of different ecosystem types. The main conclusion is that it is practically impossible to generate topologically correct integrated GIS layers from the eight ecosystem type layers. Therefore, it is necessary to develop a new approach for mapping all ecosystem types into a uniform database

Modeling of flood regulation for ecosystem accounting: a case study of Ogosta river basin

The System of Environmental-Economic Accounting – Ecosystem Accounting (SEEA-EA) is a spatially-based, integrated statistical framework for organizing biophysical information about ecosystems, measuring ecosystem services (ES). Water flow regulation ES and biophysical modeling are among the main topics in the individual ES part of the SEEA-EA framework and flood regulation ES is one of the important services. Characterizing and assessing flood regulation is a challenging task as both assessment and accounts of this ES need various data which are usually not available through direct or indirect measurements, therefore modeling approaches of water regulation are much needed. Despite growing attention and studies using hydrologic models to assess and/or map flood regulation ES, the accounting of this service is still not well developed. In this paper, we present an approach for accounting flood regulation at a local scale using ArcSWAT modeling. It is based on the results of flood regulation ES assessment, where modeling results are used to quantify the ES indicators and delineate the service providing areas (SPA) and service demand areas (SDA). The actual flow of flood regulation is calculated as a ratio between ES demand and ES potential and it represents the area of SPA which corresponds to the demand for flood regulation represented by SDA. The results show that predominant flood regulations ES supply is provided by the forest ecosystem as well as the actual flow. The accounting of flood regulation is strongly determined by ecosystem extent mapping. The CORINE Land Cover (CLC) provides the most appropriate and available data for mapping ecosystem extent at smaller scales. However, at a larger scale, it is too coarse and the combination of Mapping and Assessment of Ecosystems and their Services (MAES) national ecosystem mapping gives better results

Modeling of flood regulation for ecosystem accounting: a case study of Ogosta river basin

The System of Environmental-Economic Accounting – Ecosystem Accounting (SEEA-EA) is a spatially-based, integrated statistical framework for organizing biophysical information about ecosystems, measuring ecosystem services (ES). Water flow regulation ES and biophysical modeling are among the main topics in the individual ES part of the SEEA-EA framework and flood regulation ES is one of the important services. Characterizing and assessing flood regulation is a challenging task as both assessment and accounts of this ES need various data which are usually not available through direct or indirect measurements, therefore modeling approaches of water regulation are much needed. Despite growing attention and studies using hydrologic models to assess and/or map flood regulation ES, the accounting of this service is still not well developed. In this paper, we present an approach for accounting flood regulation at a local scale using ArcSWAT modeling. It is based on the results of flood regulation ES assessment, where modeling results are used to quantify the ES indicators and delineate the service providing areas (SPA) and service demand areas (SDA). The actual flow of flood regulation is calculated as a ratio between ES demand and ES potential and it represents the area of SPA which corresponds to the demand for flood regulation represented by SDA. The results show that predominant flood regulations ES supply is provided by the forest ecosystem as well as the actual flow. The accounting of flood regulation is strongly determined by ecosystem extent mapping. The CORINE Land Cover (CLC) provides the most appropriate and available data for mapping ecosystem extent at smaller scales. However, at a larger scale, it is too coarse and the combination of Mapping and Assessment of Ecosystems and their Services (MAES) national ecosystem mapping gives better results

Integrated mapping of ecosystems and assessment of forest ecosystem services at river basin scale

Ecosystems provide various goods and services to society and their valuation is among the main objectives of the concept of ecosystem services (ES). The mapping of ecosystems is the main building block of the whole process of the Mapping and Assessment of Ecosystems and their Services (MAES). The analyses of the ecosystem data produced during the implementation of the national methodology for mapping ecosystems in Bulgaria (MAES BG) reveal some problems that may cause confusion in cases of integrated assessment of all ecosystem types. In this paper, we present an approach that enables formulation of a uniform spatial dataset based on the mapping of the main ecosystem types, that can be used for mapping of ES at a river basin scale. It has been applied to the upper part of the Ogosta River basin and the result is a topologically correct uniform spatial data layer. The approach gives one possible solution to problems related to the different sources of information and the discrepancies between ecosystem types in the national mapping of ecosystems in Bulgaria. It is based on the use of a uniform spatial framework that outlines the ecosystem types and sets the initial database for further mapping. This ensures a topologically correct spatial dataset for the ecosystems and a background for further updates for each ecosystem at the different levels of MAES typology. The most appropriate spatial basis for the territory of Bulgaria is the database for the physical blocks of the Ministry of Interior. Its application to the studied river basin gives encouraging results and can be used as an example for similar areas. Further development of the approach will ensure the mapping of the forest ecosystems at level 3 of the MAES BG typology and more precise delineation of the grassland, heathland, freshwater, and sparsely vegetated ecosystems

Twenty years of ecosystem services research in Bulgaria: lessons learned and future directions from a geographical perspective

The ecosystem services (ES) concept has established itself in recent years as the predominant paradigm for framing environmental research and policy-making. The EU Biodiversity Strategy to 2020 with its task for member countries to map and assess the state of ecosystems and their services has contributed vastly to the development of the ES studies in the European countries. Bulgaria was among the countries that made substantial progress in its implementation and the contribution of the geographers was of vital importance. This paper aims to provide an overview and analysis of the ES research in Bulgaria focusing on the contributions of the geographers and the spatial aspects of the studies. The information on the ES research was performed through a literature review by collecting all available published works that address the main objectives of the study. To systematize and characterize the content of the reviewed papers, a special database with a standard nomenclature was constructed. The findings from the review allowed us to identify both achievements and research gaps in the ES studies conducted by Bulgarian geographers. This enabled us to define the main research priorities of the coming years which can trace the future directions of ES research in the country. They include the development of the spatial aspects in the methodological frameworks for mapping and assessment of ES, better use of GIS-based tools for mapping ES alongside models’ integration, and improvement of the publication's quality and increase of the papers published in highly rated indexed journals