Demographic and Human Capital Scenarios for the 21st Century: 2018 assessment for 201 countries

This volume presents different scenarios of future population and human capital trends in 201 countries of the world to the end of this century to inform the assessment of possible future migration patterns into the EU, as currently carried out by the Centre of Expertise on Population and Migration (CEPAM) Project (collaboration between JRC and IIASA). The study also goes beyond the conventional population projections, which only consider age and sex structures, by taking a multi-dimensional approach through adding educational attainment for all countries and also labour force participation for EU member states. The definition of scenarios in this study follows the narratives of the SSPs (Shared Socioeconomic Pathways) which are widely used in the global change research community

Adolescence and the next generation

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today\u27s adolescents, the largest cohort in human history, will yield great dividends for future generations

Adolescence and the next generation.

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today's adolescents, the largest cohort in human history, will yield great dividends for future generations

Projections of religiosity for Spain

In this study we carry out multistate population projections by religion and religiosity for Spain in the period 2010-2050. First we estimate the base population, for the year 2005 by age, sex, religion and religious intensity. We identify the size and composition of migration flows by denomination and religiosity. Differentials in childbearing patterns by religion and degree of religiosity are then calculated. We also estimate and model age- and sex-specific religious conversion rates by denomination and religiosity. We further assume that the child's religion and religiosity assumed is identical to that of mother's until the age of 15, so that the fertility differentials affect the variation in the religious (both denomination and intensity) composition of the next generation. We assume that there are no causal relation between mortality and religion. Several scenarios, based on combining different assumptions for fertility and migration, covering wider uncertainty range of the demographic future are constructed. The Spanish population disaggregated by age, sex, religion, and degree of religiosity was projected till 2050 according to these scenarios. The results are then analyzed for the sensitivity in the future structure of the population to the different assumptions on fertility and migration of future Spanish population

The religious composition of the Chinese Diaspora, focusing on Canada

The religious composition of the Chinese Diaspora varies by countries with the highest Christian share in the Philippines (86 percent) and the highest Buddhist share (84.3 percent) in Cambodia. The religiously unaffiliated are more likely found in Vietnam (74.7 percent), Canada (70.1 percent), and Austria (63 percent) and less likely found in the Philippines (0.6 percent) and Malaysia (1.5 percent). A further analysis of high-quality Canadian census data allows for a more in-depth focus. In 2001, 81 percent of the 125,000 Chinese migrants (those born in mainland China who had moved to Canada between 1996 and 2001) were unaffiliated, 11 percent were Christian, and 7 percent Buddhist. Relative to the topic of conversion, data on Chinese migrants admitted to Canada between 1981 and 1990 reveals growth in the proportion that self-identified as religiously affiliated (Christian as well as Buddhist) and a decline in the proportion who reported no religion

Attention, cognitive control and motivation in ADHD: Linking event-related brain potentials and DNA methylation patterns in boys at early school age.

In order to better understand the underpinnings of attention-deficit/hyperactivity disorder (ADHD), we targeted the relationship of attentional, cognitive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys at early school age. Participants (6 to 8 years; N = 82) were selected from a German longitudinal cohort (FRANCES). ADHD-related behaviour was assessed via maternal ratings. Performance and event-related potential measures (inter alia Cue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentional orienting, reduced inhibitory response control and a larger motivational effect on performance in ADHD already at this relatively young age. Methylation patterns were analysed in buccal cell DNA with the Illumina HumanMethylation 450K array. For CpG sites at genes of the dopaminergic (COMT, ANKK1) and the neurotrophic (BDNF, NGFR) system, associations with the Nogo-P3 as well as ADHD symptom severity were found suggesting that these systems are involved in response control deficits in ADHD. Methylation effects related to both functional aspects and ADHD behaviour were also observed for DPP10 and TPH2. Epigenetic mechanisms may play a role in ADHD-associated deficits but findings need to be replicated in larger samples and are limited by the fact that only peripheral methylation could be considered

Effects of Pharmacokinetic Gene Variation on Therapeutic Drug Levels and Antidepressant Treatment Response

Introduction Pharmacogenetic testing is proposed to minimize adverse effects when considered in combination with pharmacological knowledge of the drug. As yet, limited studies in clinical settings have investigated the predictive value of pharmacokinetic (pk) gene variation on therapeutic drug levels as a probable mechanism of adverse effects, nor considered the combined effect of pk gene variation and drug level on antidepressant treatment response. Methods Two depression cohorts were investigated for the relationship between pk gene variation and antidepressant serum concentrations of amitriptyline, venlafaxine, mirtazapine and quetiapine, as well as treatment response. For the analysis, 519 patients (49% females; 46.6 +/- 14.1 years) were included. Results Serum concentration of amitriptyline was associated with CYP2D6 (higher concentrations in poor metabolizers compared to normal metabolizers), of venlafaxine with CYP2C19 (higher concentrations in intermediate metabolizers compared to rapid/ultrarapid metabolizers) and CYP2D6 (lower metabolite-to-parent ratio in poor compared to intermediate and normal metabolizers, and intermediate compared to normal and ultrarapid metabolizers). Pk gene variation did not affect treatment response. Discussion The present data support previous recommendations to reduce starting doses of amitriptyline and to guide dose-adjustments via therapeutic drug monitoring in CYP2D6 poor metabolizers. In addition, we propose including CYP2C19 in routine testing in venlafaxine-treated patients to improve therapy by raising awareness of the risk of low serum concentrations in CYP2C19 rapid/ultrarapid metabolizers. In summary, pk gene variation can predict serum concentrations, and thus the combination of pharmacogenetic testing and therapeutic drug monitoring is a useful tool in a personalized therapy approach for depression

Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children.

Epigenetic DNA modifications in genes related to the hypothalamic-pituitary-adrenal (HPA) axis are discussed as a mechanism underlying the association between prenatal depression and altered child HPA activity. In a longitudinal study, DNA methylation changes related to prenatal depressive symptoms were investigated in 167 children aged 6 to 9 years. At six candidate genes, 126 cytosine-guanine dinucleotides were considered without correcting for multiple testing due to the exploratory nature of the study. Further associations with the basal child HPA activity were examined. Children exposed to prenatal depressive symptoms exhibited lower bedtime cortisol (p = .003, ηp2 = 0.07) and a steeper diurnal slope (p = .023, ηp2 = 0.06). For total cortisol release, prenatal exposure was related to lower cortisol release in boys, and higher release in girls. Furthermore, prenatal depressive symptoms were associated with altered methylation in the glucocorticoid receptor gene (NR3C1), the mineralocorticoid receptor gene (NR3C2), and the serotonin receptor gene (SLC6A4), with some sex-specific effects (p = .012-.040, ηp2 = 0.03-0.04). In boys, prenatal depressive symptoms predicted bedtime cortisol mediated by NR3C2 methylation, indirect effect = -0.07, 95% confidence interval [-0.16, -0.02]. Results indicate relations of prenatal depressive symptoms to both child basal HPA activity and DNA methylation, partially fitting a mediation model, with exposed boys and girls being affected differently